Araştırma Makalesi
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D Vitamini Eksikliği Olan Hastalarda Sistemik İmmün İnflamasyon İndeksinin Değişkenliği

Yıl 2022, , 984 - 991, 14.11.2022
https://doi.org/10.33715/inonusaglik.1158831

Öz

Bu çalışmada, D vitamini eksikliği olan hastalarda inflamasyonun yeni bir belirteci olarak kabul edilen sistemik immün inflamasyon indeksinin (SII) değişkenliği araştırıldı. Ayaktan tedavi olan hastaların biyokimyasal ve tam kan sayımı verileri dijital verilerden retrospektif olarak taranıp kaydedildi. SII, her hasta için tam kan parametreleri (nötrofil x trombosit/lenfosit) ile hesaplandı. SII ve D vitamini varyasyonu arasındaki ilişki araştırıldı. Çalışmaya alınan 113 hastanın yaş ortalaması 38.58±12.37 yıl idi. Ortalama D vitamini, B12 ve folat düzeyleri sırasıyla 13.68±6.57 ng/ml, 309.54±110.73 pg/ml ve 7.13±2.77 ng/ml idi. Ortalama SII 434.39±156.72 idi. D vitamini 38 hastada (%33.6) 10 ng/mL'nin altında iken, 56 hastada (%49.5) 10-20 ng/mL arasında, 19 hastada (%16.8) 20 ng/mL ve üzerindeydi. B12 vitamini birincil grupta ikincil gruba göre anlamlı derecede düşüktü (p<0.05). SII ile D vitamin değerleri arasında herhangi bir anlamlı ilişki bulunmadı (p>0.05). D vitamini eksikliği en yaygın sağlık sorunlarından biridir, D vitamini eksikliği ve inflamasyon arasındaki olası ilişkiler halen araştırılmaktadır. Bu çalışmada D vitamini eksikliği olan hastalarda SII varyasyonunu araştırıldı ancak herhangi bir ilişki bulunmadı.

Destekleyen Kurum

Yoktur

Kaynakça

  • Amrein, K., Scherkl, M., Hoffmann, M., Neuwersch-Sommeregger, S., Köstenberger, M., Tmava Berisha, A., …Malle, O. (2020). Vitamin D deficiency 2.0: An update on the current status worldwide. Eur J Clin Nutr, 74(11), 1498-1513. doi:10.1038/s41430-020-0558-y
  • Bouillon, R., Marcocci, C., Carmeliet, G., Bikle, D., White, J. H., Dawson-Hughes, B., …Bilezikian, J. (2019). Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev, 40(4), 1109-1151. doi:10.1210/er.2018-00126
  • de la Torre Lossa, P., Moreno Álvarez, M., González Guzmán, M. D. C., López Martínez, R. & Ríos Acosta, C. (2020). Vitamin D is not useful as a biomarker for disease activity in rheumatoid arthritis. Reumatol Clin (Engl Ed), 16(2 Pt 1), 110-115. doi:10.1016/j.reuma.2018.02.016
  • Dickie, L. J., Church, L. D., Coulthard, L. R., Mathews, R. J., Emery, P. & McDermott, M. F. (2010). Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology (Oxford), 49(8), 1466-1471. doi:10.1093/rheumatology/keq124
  • Fest, J., Ruiter, R., Mulder, M., Groot Koerkamp, B., Ikram, M. A., Stricker, B. H. & van Eijck, C. H. J. (2020). The systemic immune-inflammation index is associated with an increased risk of incident cancer-A population-based cohort study. Int J Cancer, 146(3), 692-698. doi:10.1002/ijc.32303
  • Goyal, H., Perisetti, A., Rahman, M. R., Levin, A. & Lippi, G. (2019). Vitamin D and Gastrointestinal Cancers: A Narrative Review. Dig Dis Sci, 64(5), 1098-1109. doi:10.1007/s10620-018-5400-1
  • Gündüz, M. & Karaaslan, E. (2020). COVID-19 reminds us: community vitamin D deficiency. Ann Ital Chir, 91, 673-678. Hilger, J., Friedel, A., Herr, R., Rausch, T., Roos, F., Wahl, D. A., …Hoffmann, K. (2014). A systematic review of vitamin D status in populations worldwide. Br J Nutr, 111(1), 23-45. doi:10.1017/s0007114513001840
  • Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med, 357(3), 266-281. doi:10.1056/NEJMra070553
  • Hou, D., Wang, C., Luo, Y., Ye, X., Han, X., Feng, Y., …Wu, D. (2021). Systemic immune-inflammation index (SII) but not platelet-albumin-bilirubin (PALBI) grade is associated with severity of acute ischemic stroke (AIS). Int J Neurosci, 131(12), 1203-1208. doi:10.1080/00207454.2020.1784166
  • Karaaslan, T. & Karaaslan, E. (2022). Predictive Value of Systemic Immune-inflammation Index in Determining Mortality in COVID-19 Patients. The Journal of Critical Care Medicine, 8(3), 156-164. doi:doi:10.2478/jccm-2022-0013
  • Kaya, T., Akçay, E., Ertürk, Z., Ergenç, H. & Tamer, A. (2018). The relationship between vitamin D deficiency and erythrocyte sedimentation rate in patients with diabetes. Turk J Med Sci, 48(2), 424-429. doi:10.3906/sag-1712-28
  • Keum, N., Lee, D. H., Greenwood, D. C., Manson, J. E. & Giovannucci, E. (2019). Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. Ann Oncol, 30(5), 733-743. doi:10.1093/annonc/mdz059
  • Kim, H. S., Rotundo, L., Kothari, N., Kim, S. H. & Pyrsopoulos, N. (2017). Vitamin D Is Associated with Severity and Mortality of Non-alcoholic Fatty Liver Disease: A US Population-based Study. J Clin Transl Hepatol, 5(3), 185-192. doi:10.14218/jcth.2017.00025
  • Lappe, J., Watson, P., Travers-Gustafson, D., Recker, R., Garland, C., Gorham, E., …McDonnell, S. L. (2017). Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. Jama, 317(12), 1234-1243. doi:10.1001/jama.2017.2115
  • Li, H., Wang, G., Zhang, H., Song, X., Cao, J., Zhang, X., …Li, Z. (2019). Prognostic role of the systemic immune-inflammation index in brain metastases from lung adenocarcinoma with different EGFR mutations. Genes Immun, 20(6), 455-461. doi:10.1038/s41435-018-0050-z
  • Li, S., Zhang, Q., Gao, Y., Nie, K., Liang, Y., Zhang, Y. & Wang, L. (2021). Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study. Front Neurol, 12, 665075. doi:10.3389/fneur.2021.665075
  • Manson, J. E., Bassuk, S. S. & Buring, J. E. (2017). Vitamin D, Calcium, and Cancer: Approaching Daylight? Jama, 317(12), 1217-1218. doi:10.1001/jama.2017.2155
  • Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., ... Camargo, C. A., Jr. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. Bmj, 356, i6583. doi:10.1136/bmj.i6583
  • Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., …Camargo, C. A. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. Bmj, 356, i6583. doi:10.1136/bmj.i6583.
  • Medical Advisory Secretariat (2010). Clinical utility of vitamin d testing: an evidence-based analysis. Ontario health technology assessment series, 10(2), 1–93.
  • Mitchell, F. (2020). Vitamin-D and COVID-19: do deficient risk a poorer outcome? Lancet Diabetes Endocrinol, 8(7), 570. doi:10.1016/s2213-8587(20)30183-2
  • Mosekilde, L. (2008). Vitamin D requirement and setting recommendation levels: long-term perspectives. Nutr Rev, 66(10 Suppl 2), S170-177. doi:10.1111/j.1753-4887.2008.00103.x
  • Nøst, T. H., Alcala, K., Urbarova, I., Byrne, K. S., Guida, F., Sandanger, T. M. & Johansson, M. (2021). Systemic inflammation markers and cancer incidence in the UK Biobank. Eur J Epidemiol, 36(8), 841-848. doi:10.1007/s10654-021-00752-6
  • Palacios, C. & Gonzalez, L. (2014). Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol, 144 Pt A, 138-145. doi:10.1016/j.jsbmb.2013.11.003
  • Secretariat, M. A. (2010). Clinical utility of vitamin d testing: an evidence-based analysis. Ont Health Technol Assess Ser, 10(2), 1-93.
  • Toyoda, J., Sahara, K., Maithel, S. K., Abbott, D. E., Poultsides, G. A., Wolfgang, C., …Pawlik, T. M. (2022). Prognostic Utility of Systemic Immune-Inflammation Index After Resection of Extrahepatic Cholangiocarcinoma: Results from the U.S. Extrahepatic Biliary Malignancy Consortium. Ann Surg Oncol. doi:10.1245/s10434-022-12058-2
  • Vanoirbeek, E., Krishnan, A., Eelen, G., Verlinden, L., Bouillon, R., Feldman, D. & Verstuyf, A. (2011). The anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃. Best Pract Res Clin Endocrinol Metab, 25(4), 593-604. doi:10.1016/j.beem.2011.05.001
  • Wu, J., Yan, L. & Chai, K. (2021). Systemic immune-inflammation index is associated with disease activity in patients with ankylosing spondylitis. J Clin Lab Anal, 35(9), e23964. doi:10.1002/jcla.23964
  • Yang, Y. L., Wu, C. H., Hsu, P. F., Chen, S. C., Huang, S. S., Chan, W. L., …Leu, H. B. (2020). Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest, 50(5), e13230. doi:10.1111/eci.13230

THE VARIATION OF THE SYSTEMIC IMMUNE-INFLAMMATION INDEX IN THE PATIENTS WITH VITAMIN D DEFICIENCY

Yıl 2022, , 984 - 991, 14.11.2022
https://doi.org/10.33715/inonusaglik.1158831

Öz

In this study, the variability of the systemic immune inflammation index (SII), which is accepted as a new marker of inflammation, was researched in patients with vitamin D deficiency. The biochemistry and hemogram results of outpatients were scanned and recorded retrospectively from digital data. SII was calculated with whole blood parameters (neutrophil x platelet/lymphocyte) for each patient. The relationship between SII and vitamin D variation was investigated. The mean age of 113 patients included in the study was 38.58±12.37 years. Mean levels of vitamin D, B12, and folate were 13.68±6.57 ng/ml, 309.54±110.73 pg/ml and 7.13±2.77 ng/ml, respectively. The mean SII was 434.39±156.72. While vitamin D was below 10 ng/mL in 38 patients (33.6%), it was between 10-20 ng/mL in 56 patients (49.5%) and 20 ng/mL and above in 19 patients (16.8%). Vitamin B12 was lower in the primary group than in the second group (p<0.05). No significant correlation was found between SII and vitamin D values (p>0.05). Vitamin D deficiency is one of the most common health problems, and possible relationships between vitamin D deficiency and inflammation are still under investigation. In this study, we researched the SII variation in patients with vitamin D deficiency, but no relationship was observed.

Kaynakça

  • Amrein, K., Scherkl, M., Hoffmann, M., Neuwersch-Sommeregger, S., Köstenberger, M., Tmava Berisha, A., …Malle, O. (2020). Vitamin D deficiency 2.0: An update on the current status worldwide. Eur J Clin Nutr, 74(11), 1498-1513. doi:10.1038/s41430-020-0558-y
  • Bouillon, R., Marcocci, C., Carmeliet, G., Bikle, D., White, J. H., Dawson-Hughes, B., …Bilezikian, J. (2019). Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev, 40(4), 1109-1151. doi:10.1210/er.2018-00126
  • de la Torre Lossa, P., Moreno Álvarez, M., González Guzmán, M. D. C., López Martínez, R. & Ríos Acosta, C. (2020). Vitamin D is not useful as a biomarker for disease activity in rheumatoid arthritis. Reumatol Clin (Engl Ed), 16(2 Pt 1), 110-115. doi:10.1016/j.reuma.2018.02.016
  • Dickie, L. J., Church, L. D., Coulthard, L. R., Mathews, R. J., Emery, P. & McDermott, M. F. (2010). Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology (Oxford), 49(8), 1466-1471. doi:10.1093/rheumatology/keq124
  • Fest, J., Ruiter, R., Mulder, M., Groot Koerkamp, B., Ikram, M. A., Stricker, B. H. & van Eijck, C. H. J. (2020). The systemic immune-inflammation index is associated with an increased risk of incident cancer-A population-based cohort study. Int J Cancer, 146(3), 692-698. doi:10.1002/ijc.32303
  • Goyal, H., Perisetti, A., Rahman, M. R., Levin, A. & Lippi, G. (2019). Vitamin D and Gastrointestinal Cancers: A Narrative Review. Dig Dis Sci, 64(5), 1098-1109. doi:10.1007/s10620-018-5400-1
  • Gündüz, M. & Karaaslan, E. (2020). COVID-19 reminds us: community vitamin D deficiency. Ann Ital Chir, 91, 673-678. Hilger, J., Friedel, A., Herr, R., Rausch, T., Roos, F., Wahl, D. A., …Hoffmann, K. (2014). A systematic review of vitamin D status in populations worldwide. Br J Nutr, 111(1), 23-45. doi:10.1017/s0007114513001840
  • Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med, 357(3), 266-281. doi:10.1056/NEJMra070553
  • Hou, D., Wang, C., Luo, Y., Ye, X., Han, X., Feng, Y., …Wu, D. (2021). Systemic immune-inflammation index (SII) but not platelet-albumin-bilirubin (PALBI) grade is associated with severity of acute ischemic stroke (AIS). Int J Neurosci, 131(12), 1203-1208. doi:10.1080/00207454.2020.1784166
  • Karaaslan, T. & Karaaslan, E. (2022). Predictive Value of Systemic Immune-inflammation Index in Determining Mortality in COVID-19 Patients. The Journal of Critical Care Medicine, 8(3), 156-164. doi:doi:10.2478/jccm-2022-0013
  • Kaya, T., Akçay, E., Ertürk, Z., Ergenç, H. & Tamer, A. (2018). The relationship between vitamin D deficiency and erythrocyte sedimentation rate in patients with diabetes. Turk J Med Sci, 48(2), 424-429. doi:10.3906/sag-1712-28
  • Keum, N., Lee, D. H., Greenwood, D. C., Manson, J. E. & Giovannucci, E. (2019). Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. Ann Oncol, 30(5), 733-743. doi:10.1093/annonc/mdz059
  • Kim, H. S., Rotundo, L., Kothari, N., Kim, S. H. & Pyrsopoulos, N. (2017). Vitamin D Is Associated with Severity and Mortality of Non-alcoholic Fatty Liver Disease: A US Population-based Study. J Clin Transl Hepatol, 5(3), 185-192. doi:10.14218/jcth.2017.00025
  • Lappe, J., Watson, P., Travers-Gustafson, D., Recker, R., Garland, C., Gorham, E., …McDonnell, S. L. (2017). Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. Jama, 317(12), 1234-1243. doi:10.1001/jama.2017.2115
  • Li, H., Wang, G., Zhang, H., Song, X., Cao, J., Zhang, X., …Li, Z. (2019). Prognostic role of the systemic immune-inflammation index in brain metastases from lung adenocarcinoma with different EGFR mutations. Genes Immun, 20(6), 455-461. doi:10.1038/s41435-018-0050-z
  • Li, S., Zhang, Q., Gao, Y., Nie, K., Liang, Y., Zhang, Y. & Wang, L. (2021). Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study. Front Neurol, 12, 665075. doi:10.3389/fneur.2021.665075
  • Manson, J. E., Bassuk, S. S. & Buring, J. E. (2017). Vitamin D, Calcium, and Cancer: Approaching Daylight? Jama, 317(12), 1217-1218. doi:10.1001/jama.2017.2155
  • Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., ... Camargo, C. A., Jr. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. Bmj, 356, i6583. doi:10.1136/bmj.i6583
  • Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., …Camargo, C. A. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. Bmj, 356, i6583. doi:10.1136/bmj.i6583.
  • Medical Advisory Secretariat (2010). Clinical utility of vitamin d testing: an evidence-based analysis. Ontario health technology assessment series, 10(2), 1–93.
  • Mitchell, F. (2020). Vitamin-D and COVID-19: do deficient risk a poorer outcome? Lancet Diabetes Endocrinol, 8(7), 570. doi:10.1016/s2213-8587(20)30183-2
  • Mosekilde, L. (2008). Vitamin D requirement and setting recommendation levels: long-term perspectives. Nutr Rev, 66(10 Suppl 2), S170-177. doi:10.1111/j.1753-4887.2008.00103.x
  • Nøst, T. H., Alcala, K., Urbarova, I., Byrne, K. S., Guida, F., Sandanger, T. M. & Johansson, M. (2021). Systemic inflammation markers and cancer incidence in the UK Biobank. Eur J Epidemiol, 36(8), 841-848. doi:10.1007/s10654-021-00752-6
  • Palacios, C. & Gonzalez, L. (2014). Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol, 144 Pt A, 138-145. doi:10.1016/j.jsbmb.2013.11.003
  • Secretariat, M. A. (2010). Clinical utility of vitamin d testing: an evidence-based analysis. Ont Health Technol Assess Ser, 10(2), 1-93.
  • Toyoda, J., Sahara, K., Maithel, S. K., Abbott, D. E., Poultsides, G. A., Wolfgang, C., …Pawlik, T. M. (2022). Prognostic Utility of Systemic Immune-Inflammation Index After Resection of Extrahepatic Cholangiocarcinoma: Results from the U.S. Extrahepatic Biliary Malignancy Consortium. Ann Surg Oncol. doi:10.1245/s10434-022-12058-2
  • Vanoirbeek, E., Krishnan, A., Eelen, G., Verlinden, L., Bouillon, R., Feldman, D. & Verstuyf, A. (2011). The anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃. Best Pract Res Clin Endocrinol Metab, 25(4), 593-604. doi:10.1016/j.beem.2011.05.001
  • Wu, J., Yan, L. & Chai, K. (2021). Systemic immune-inflammation index is associated with disease activity in patients with ankylosing spondylitis. J Clin Lab Anal, 35(9), e23964. doi:10.1002/jcla.23964
  • Yang, Y. L., Wu, C. H., Hsu, P. F., Chen, S. C., Huang, S. S., Chan, W. L., …Leu, H. B. (2020). Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest, 50(5), e13230. doi:10.1111/eci.13230
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Banu Büyükaydın 0000-0003-2843-4209

Tahsin Karaaslan 0000-0002-1529-1790

Yayımlanma Tarihi 14 Kasım 2022
Gönderilme Tarihi 7 Ağustos 2022
Kabul Tarihi 9 Ekim 2022
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

APA Büyükaydın, B., & Karaaslan, T. (2022). THE VARIATION OF THE SYSTEMIC IMMUNE-INFLAMMATION INDEX IN THE PATIENTS WITH VITAMIN D DEFICIENCY. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi, 10(3), 984-991. https://doi.org/10.33715/inonusaglik.1158831