Biocompatible Biomaterials Used in Medical Applications

Yıl 2020, , 515 - 526, 21.06.2020

Zehra Deniz Çırak , Derya Büşra Yakıncı

https://doi.org/10.33715/inonusaglik.745301

Cited By: 4

Öz

Biomaterials are natural or artificial materials that replace part of a living system or are used to work in contact with living tissue. In addition to their usage in replacing diseased or damaged organs or tissues, spinal stabilizers are used to correct some body functions, biomaterials such as contact lenses, pacemakers, hearing aids are used to increase the functionality of some organs. Biomaterials are used in many areas such as surgical thread, screws, skin implantation, silicones, braces and dental implants. While biomaterials continue its technological development, it appears that biocompatibility is very important. Adverse conditions may occur when biomaterials used in medical applications come into contact with living tissue for a certain or continual period of time. To overcome these problems and to produce biocompatible biomaterials is a multidisciplinary field of study. In this study, basic biomaterial types, their use in medical applications and the importance of the production of future new-generation biocompatible biomaterials are indicated.

Anahtar Kelimeler

Biocompatibility, Biomaterial, Implant

TIBBİ UYGULAMALARDA KULLANILAN BİYOUYUMLU BİYOMALZEMELER

Öz

Biyomalzemeler, canlı bir sistemin parçası yerine geçen veya canlı doku ile temas içinde çalışması için kullanılan doğal veya yapay malzemelerdir. Hastalıklı veya hasar görmüş organ ya da dokuların yerine kullanılmaları yanı sıra, bazı vücut fonksiyonlarını düzeltmek için omurga sabitleyiciler, bazı organların fonksiyonelliğini artırmak için kontakt lens, kalp pili, işitme cihazı gibi biyomalzemeler kullanılmaktadır. Ameliyat ipliği, vidalar, deri implantasyonu, silikonlar, diş telleri ve dental implantlar gibi pek çok alanda biyomalzemeler kullanılmaktadır. Biyomalzemeler, teknolojik gelişmesini sürdürürken biyouyumluluklarının çok önemli olduğu karşımıza çıkmaktadır. Tıbbi uygulamalarda kullanılan biyomalzemelerin belli bir süre veya sürekli canlı dokuyla teması sırasında olumsuz durumlar ortaya çıkabilmektedir. Bu olumsuzlukların giderilebilmesi işlemleri ve biyouyumlu biyomalzeme üretimi bir multidisipliner çalışma alanıdır. Bu çalışmada temel biyomalzeme çeşitleri, tıbbi uygulamalardaki kullanımları ve gelecekteki yeni-nesil biyouyumlu biyomalzemelerin üretiminin önemi belirtilmiştir.

Anahtar Kelimeler

Biyomalzeme, Biyouyum, İmplant

Kaynakça

• Aguilar M.R, San Román J.(2019) -Smart polymers and their applications. Woodhead Publishing. Second Edition.
• Alves A.C, Wenger F, Ponthiaux P, Celis J-P, Pinto AM, Rocha LA, Fernandesg, J.C.S. .(2017) "Corrosion Mechanisms İn Titanium Oxide-Based Films Produced By Anodic Treatment". Electrochimica Acta, 234, 16-27
• Ayhan, H.(2002) Biyomalzemeler Hacettepe Üniversitesi Bilim Teknik Dergisi,17
• Chevalier J. (2006). What Future For Zirconia As A Biomaterial? Biomaterials ,27, 535-43
• Chung Ddl.(2002). Composite Materials: Functional Materials For Modern Technologies. Springer, London
• Chunxiang, C., Baomin, H., Lichen, Z., Shuangjin, L.(2011) “Titanium Alloy Production Technology, Market Prospects And İndustry Development”, Materials And Design, 32, 1684–1691
• Çömlekoğlu, E., Dündar, M., Güngör, MA., Aladağ, A., Artunç, A., (2008). Allergy İn Dentistry: Casting Alloys, Polymers And Ceramics, Eü Dişhek Fak Derg. 29, 81-92
• Domínguez-Trujillo C, Peón E, Chicardi E, Pérez H, Rodríguez-Ortiz Ja, Pavón Jj, Et Al. (2018)."Sol-Gel Deposition Of Hydroxyapatite Coatings On Porous Titanium For Biomedical Applications". Surface And Coatings Technology, 333, 158-162
• Duerig, T.W., Melton, K.N., Stockel, D., And Wayman, C.M., (1990). Engineering Aspects Of Shape Memory Alloys, Butterworth-Heinemann, London, Eds.
• Sarsılmaz F., Sarsılmaz, C.(2003) Ortopedide Kullanılan Polimer Esaslı Kompozit Malzemeler.Doğu Anadolu Bölgesi Araştırmaları.3,2003
• Gómez-Mascaraque Lg, Palao-Suay R (2019).Smart Polymers And Their Applications (Second Edition) Woodhead Publishing İn Materials 481-531
• Guazzato M, Albakry M, Quach L, Swain Mv. (2004). Influence Of Grinding, Sandblasting, Polishing And Heat Treatment On The Flexural Strength Of A Glassinfiltrated Alumina-Reinforced Dental Ceramic. Biomaterials , 25, 2153-60
• Guedes R.M (2019). Creep and fatigue in polymer matrix composites. Woodhead Publishing. Second edition.
• Gümüşderelioğlu, M. (2002). Biyomalzemeler Bilim Ve Teknik Tubitak Temmuz 2002
• Gür, A.K.,, Taşkın, M., (2004), Metalik Biyomalzemeler ve Biyouyum, Doğu Anadolu Bölgesi Araştırmaları :4
• Güven, Ş.,Y., (2010), Ortopedik Malzemelerin Biyouyumlulukları Ve Mekanik Özelliklerine Göre Seçimi, Ulusal Tasarım İmalat Ve Analiz Kongresi 11-12 Kasım, Balıkesir, 472-484
• Lee, H.B., Khang, G., Lee,J.H (2000).Polymeric Biomaterials, The Biomedical Engineering Handbook, Second Edition. Crc Press Llc,
• He, G., Eckert, J., Dai, Q.L., Sui, M.L., Löser, W., Hagiwara, M., Et Al. (2003) Nanostructured Ti-Based Multicomponent Alloys With Potential For Biomedical Applications, Biomaterials, 24(5),115–200.
• Hench L.L .(1991).J. Am. Ceram. Soc. 74, 1487-1510
• Hench LL, Wilson J. (1993). An introduction to bioceramics. 31st ed. Singapore: World Scientific Publishing Hench, L.L., Wilson, J., (1984). Surface Active Biomaterials. Science; 226: 630-636 Hrabe, N.W.,(2010). “Characterization Of Cellular Titanium For Biomedical Applications”, Doctor Of Philosophy, University Of Washington
• Ivasyshyn, O.M, Aleksandrov, A.V.,(2008). “Status Of The Titanium Production, Research, And Applications İn The Cıs”, Mater Sci, 44(3), 311–327
• Jain P, Ranjan M. (2015). The Rise Of Biocramics İn Endodontics: A Review. Int J Pharma Bio Sci.6(1),416–22 Jian Z, Minglong X, Zhichun Y,( 2019).Aeroelastic Stability Analysis Of Curved Composite Panels With Embedded Macro Fiber Composite Actuators, Composite Structures, 208, 725-734
• Kaya, A.İ. (2016). Kompozit Malzemeler Ve Özellikleri. Putech & Composite Poliüretan Ve Kompozit Sanayi Dergisi 29, 38-45
• Leutjering, G., Williams, J.C., (2003). “Titanium”, Springer, New York Mantovani, D.,(2000). Sahpe Memory Alloys: Properties And Biomedical Applications. Metals&Materials Society, 36-44.
• Maitz M.F. (2015)Applications of synthetic polymers in clinical medicine. Biosurface and Biotribology, 1 (3), 161-176
• Murr, L. (2017) Open-Cellular Metal İmplant Design And Fabrication For Biomechanical Compatibility With Bone Using Electron Beam Meltingj. Mech. Behav. Biomed. Mater., 76 ,164-177
• Niinomi, M., 2002, Recently Metalic Materials For Biomedical Applications, Metalurgical And Materials Transactions; Warrendale ,477-486
• Park, J.B., Kim, Y.K., 2000. Metallic Biomaterials, The Biomedical Engineering Handbook: Second Edition. Crc Press Llc,
• Pasinli, A. (2004). Biyomedikal Uygulamalarda Kullanılan Biyomalzemeler, Makine Teknolojileri Elektronik Dergisi (Teknolojik Araştırmalar Teknik Not) 4, 25-34
• Rahimizadeh A, Nourmohammadi Z, Arabnejad S, Tanzer M, Pasini D. (2017)"Porous Architected Biomaterial For A Tibialknee İmplant With Minimum Bone Resorption And Boneimplant İnterface Micromotion". Journal Of The Mechanical Behavior Of Biomedical Materials, 78, 465-479, 2018
• Sathyakumar S, Rajkumar K, Mahalaxmi S, Meenakshi Sundaram K, Ragavi P.(2011). Brush away demineralization-An in vitro SEM study. Streamdent, 2(3); 2011; 186-90
• Williams, D.F. (1982). Biocompatibility in Clinical Practice, Boca Raton, F.L., CRC Press.,8
• Williams D.F.(1987). Definitions İn Biomaterials, , Ed., Elsevier, Amsterdam, 72 Pp.
• Williams, D.F.(1987) İn Proceedings Of Consensus Conference Of The European Society For Biomaterials, Chester, (Elsevier, Amsterdam, İn Press
• Williams, D.F. (1991). Materials For Surgical İmlants. Met. Mater. 1:24-29
• Williams D.F. (2011).The Williams Dictionary Of Biomaterials. Liverpool, Liverpool University Press Yianni, J.P. (1995)"Making PVC More Biocompatible", Medical Devices Technology,20-29