Periferik ve Santral Fasiyal Paralizide Yeni Bir İnflamatuar Belirteç Olarak Sistemik İmmün-İnflamasyon İndeksinin Rolü ve Değerlendirilmesi

Yıl 2023, Cilt: 11 Sayı: 3, 1792 - 1801, 16.10.2023

İsmail Demir Ahmet Adıgüzel

https://doi.org/10.33715/inonusaglik.1325129

Öz

Sistemik immün-inflamasyon indeksi (SII) yeni bir inflamatuar belirteç olup, genellikle prognoz ve tedaviye yanıt gibi klinik takiplerde kullanılır. Bu çalışmada santral ve periferik fasiyal paralizilerde inflamatuvar belirteçlerin sonuçları ve korelasyonları değerlendirildi. Çalışma retrospektif ve kesitsel olarak planlandı. Araştırmaya toplam 133 (grup 1; 53, grup 2; 80) hasta dâhil edildi. Nötrofil sayısı 1. ve 2. gruplarda sırasıyla; 4.7 ± 1.6 ve 3.7 ± 1.6 (p=0.001) iken, lenfosit sayıları 2.8 ± 0.8 ve 3.3 ± 1 (p=0.007) tespit edildi. Santral fasiyal paralizisi olanlarda Nötrofil lenfosit oranı (NLR) 1.8 ± 0.9 iken, periferik fasiyal paralizisi olanlarda NLR 1.4 ± 1 (p=0.001) olarak analiz edildi. Sistemik immün-inflamasyon indeksi; birinci grupta 529.5 ± 297.4, ikinci grupta 408.2 ± 228.1 olarak tespit edildi (p=0.029). NLR ile SII arasında pozitif korelasyon (r:0.787, p<0.001) vardı. Periferik fasiyal paralizisi olanlar H-B skalasına göre değerlendirildi [(median:3, min-max:2-6)]. Sonuç olarak, merkezi sinir sistemini etkileyen patolojilerde inflamatuar belirteçlerdeki artış dikkat çekmiştir. NLR ve SII değerleri santral fasiyal paralizide daha yükselmiştir.

Anahtar Kelimeler

İnflamasyon, Fasiyal paralizi, Fasiyal sinir, Nötrofil Lenfosit Oranı (NLR), Sistemik İmmün-İnflamasyon İndeksi (SII)

THE ROLE AND ASSESSMENT OF SYSTEMIC IMMUNE-INFLAMMATION INDEX AS A NOVEL INFLAMMATORY MARKER IN PERIPHERAL AND CENTRAL FACIAL PARALYSIS

Öz

Systemic immune-inflammation index (SII) is a novel inflammatory marker and is commonly used in clinical management such as prognosis and response to therapies. In this study, the outcomes and correlations of inflammatory markers in central and peripheral facial paralysis were evaluated. The study was planned retrospectively and cross-sectionally. Totally 133 patients (group 1; 53, group 2; 80) were included in the study. The neutrophil counts were 4.7 ± 1.6 and 3.7 ± 1.6 (p=0.001), and the lymphocyte counts were 2.8 ± 0.8 and 3.3 ± 1 (p=0.007) in groups 1 and 2, respectively. While Neutrophil lymphocyte ratio (NLR) was 1.8 ± 0.9 in patients with central facial paralysis, NLR was analysed as 1.4 ± 1 in patients with peripheral facial paralysis (p=0.001). Systemic immune-inflammation index was determined as 529.5 ± 297.4 in the first group and 408.2 ± 228.1 in the second group (p=0.029). There was a positive correlation between NLR and SII (r:0.787, p<0.001). Peripheral facial paralysis was evaluated according to the H-B scale [(median:3, min-max:2-6)]. In conclusion, an elevated level of inflammatory markers was remarkable in pathologies affecting the central nervous system. NLR and SII values were increased in central facial paralysis.

Anahtar Kelimeler

Inflammation, Facial nerve, Facial paralysis, Neutrophil Lymphocyte Ratio (NLR), Systemic Immune-Inflammation Index (SII)

Teşekkür

Infinite gratitude and regards to Dr. Nusret Ayaz, graduate of Uludag University Faculty of Medicine, 2010

Kaynakça

• Dehghanei, M., ArefNezhad, R. & Motedayyen, H. (2020). The predicting role of neutrophil–lymphocyte ratio in patients with acute ischemic and hemorrhagic stroke. Journal of Stroke and Cerebrovascular Diseases, 29(11), 105233.
• Emsley, H. C., Smith, C. J., Tyrrell, P. J. & Hopkins, S. J. (2008). Inflammation in acute ischemic stroke and its relevance to stroke critical care. Neurocritical Care, 9, 125-138.
• Gunaldi, M., Goksu, S., Erdem, D., Gunduz, S., Okuturlar, Y., Tiken, E., …Yildirim, M. (2015). Prognostic impact of platelet/lymphocyte and neutrophil/lymphocyte ratios in patients with gastric cancer: A multicenter study. International Journal of Clinical and Experimental Medicine, 8(4), 5937.
• House, J. W. & Brackmann, D. E. (1985). Facial nerve grading system. Otolaryngology—Head and neck surgery, 93(2), 146-147.
• Kınar, A., Ulu, Ş., Bucak, A. & Kazan, E. (2021). Can systemic immune-inflammation index (SII) be a prognostic factor of Bell’s palsy patients? Neurological Sciences, 42, 3197-3201.
• Kum, R. O., Yurtsever Kum, N., Ozcan, M., Yilmaz, Y. F., Gungor, V., Unal, A. & Ciliz, D. S. (2015). Elevated neutrophil-to-lymphocyte ratio in Bell’s palsy and its correlation with facial nerve enhancement on MRI. Otolaryngology--Head and Neck Surgery, 152(1), 130-135.
• Li, L. H., Chen, C. T., Chang, Y. C., Chen, Y.-J., Lee, I. H. & How, C. K. (2021). Prognostic role of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index in acute ischemic stroke: A STROBE-compliant retrospective study. Medicine, 100(25), e26354.
• Looker, K. J., Magaret, A. S., May, M. T., Turner, K. M., Vickerman, P., Gottlieb, S. L. & Newman, L. M. (2015). Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012. PloS One, 10(10), e0140765.
• Mărgăritescu, O., Mogoantă, L., Pirici, I., Pirici, D., Cernea, D. & Mărgăritescu, C. (2009). Histopathological changes in acute ischemic stroke. Rom J Morphol Embryol, 50(3), 327-339.
• Oya, R., Takenaka, Y., Imai, T., Sato, T., Oshima, K., Ohta, Y. & Inohara, H. (2019). Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as prognostic hematologic markers of Bell's palsy: a meta-analysis. Otology & Neurotology, 40(5), 681-687.
• Özler, G. S. & Günak, G. (2014). Neutrophil-lymphocyte ratio: a new predictive and prognostic factor in patients with Bell palsy. Journal of Craniofacial Surgery, 25(3), 944-945.
• Pagliano, P. Spera, A. M., Ascione, T. & Esposito, S. (2020). Infections causing stroke or stroke-like syndromes. Infection, 48, 323-332.
• Sahin, C. & Varım, C. (2017). Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume and red cell distribution width measures in bells palsy. Open Access Macedonian Journal of Medical Sciences, 5(1), 14.
• Stjernquist-Desatnik, A., Skoog, E. & Aurelius, E. (2006). Detection of herpes simplex and varicella-zoster viruses in patients with Bell's palsy by the polymerase chain reaction technique. Annals of Otology, Rhinology & Laryngology, 115(4), 306-311.
• Urra, X., Cervera, Á., Villamor, N., Planas, A. & Chamorro, A. (2009). Harms and benefits of lymphocyte subpopulations in patients with acute stroke. Neuroscience, 158(3), 1174-1183.
• Yang, R., Chang, Q., Meng, X., Gao, N. & Wang, W. (2018). Prognostic value of systemic immune-inflammation index in cancer: a meta-analysis. Journal of Cancer, 9(18), 3295.
• Yılmaz, M., Tarakcıoǧlu, M., Bayazıt, N., Bayazıt, Y. A., Namıduru, M. & Kanlıkama, M. (2002). Serum cytokine levels in Bell's palsy. Journal of the Neurological Sciences, 197(1-2), 69-72.
• Zhang, W., Xu, L., Luo, T., Wu, F., Zhao, B. & Li, X. (2020). The etiology of Bell’s palsy: A review. Journal of Neurology, 267, 1896-1905.