Diyaliz Tedavisi Uygulanan ve Uygulanmayan Kronik Böbrek Yetmezlikli Hastalarda Protein Oksidasyon Ürünlerinin Değerlendirilmesi

Yıl 2018, Cilt: 8 Sayı: 1, 11 - 17, 30.04.2018

Cihan Coşkun , Alev Kural Macit Koldaş

Öz

DOI: 10.26650/experimed.2018.430561

Amaç: Bu çalışmada replasman tedavisi alan
ve almayan kronik böbrek yetmezliği (KBY) hastalarının kan protein oksidasyon
ürünlerinin düzeylerini değerlendirmek ve hasta kişiler ile sağlıklı kişileri
karşılaştırmak için kontrol grubu (n=35) ve hasta grupları oluşturuldu.

Gereç ve Yöntem: Hasta grupları replasman
tedavisi almayan KBY hasta grubu (n=36), hemodiyaliz (HD) tedavisi gören hasta
grubu (n=64) ve periton diyaliz (PD) tedavisi gören hasta grubu (n=21) olmak
üzere şekillendirildi. Daha sonra ileri düzey okside protein ürünleri (AOPP) ve
ileri glikasyon son ürünleri (AGE)’in düzeyleri bakımından bu gruplar
değerlendirildi.

Bulgular: Sonuç olarak, replasman tedavisi
almayan KBY hasta grubunun AGE düzeyleri haricinde, diğer tüm grupların AOPP ve
AGE düzeylerinin kontrol grubuna göre artmış olduğu saptandı. İstatistiksel
olarak en önemli artışın ise HD hasta grubunda olduğu tespit edildi. Grup içi
değerlendirmeler sonucunda hiçbir grupta AOPP ve AGE düzeyleri arasında ilişki
saptanmadı.

Sonuç: Bu sonuçlara göre KBY’nin oksidatif
stresle birlikte seyrettiği, replasman tedavisi gören KBY hastalarında ve
özellikle de HD tedavisi gören hastalarda oksidatif stresin çok daha şiddetli
olduğu gözlemlendi. Son olarak, HD tedavisi gören gruptaki hastaların diyabet
olup olmamasının sonuçları etkilemediği görüldü.

Anahtar Kelimeler

Kronik böbrek yetmezliği, hemodiyaliz, periton diyalizi, ileri düzey okside protein ürünleri, ileri glikasyon son ürünleri

Evaluation of Protein Oxidation Products in Patients With Chronic Renal Failure Receiving Dialysis or Not

Öz

DOI: 10.26650/experimed.2018.430561

Objective: In this study, control (n=35)
and groups were formed to evaluate the levels of blood protein oxidation
products in patients with chronic renal failure (CRF) who did and did not
receive replacement therapy and to compare the patients with healthy subjects.

Material and Method: The groups were the
CRF (n=36) group that did not receive replacement therapy, patients who were
undergoing hemodialysis (HD) (n=64), and patients who were undergoing
peritoneal dialysis (PD) (n=21). These groups were evaluated for the production
of advanced oxidation protein product (AOPP) and advanced glycated end product
(AGE) levels.

Results: As results, the AOPP and AGE
values of all groups increased compared to the control group, except for the
AGE levels of the patients with CRF who did not receive replacement therapy.
The most significant increase was found in the HD patient group. No
relationship was detected between the AOPP and AGE values in any group.

Conclusion: According to these results, CRF
is accompanied by oxidative stress, and the oxidative stress is much more
severe in patients with CRF receiving replacement therapy, particularly in
patients undergoing HD. Is unknown if the results of patients undergoing HD
were affected by the presence of diabetes.

Anahtar Kelimeler

Advanced glycated end products, advanced oxidation protein products, chronic renal failure, hemodialysis, peritoneal dialysis

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