EVALUATION OF HELICOBACTER PYLORI FREQUENCY AND GASTRIC ANTRUM PATHOLOGY FINDINGS IN PATIENTS WITH PORTAL HYPERTENSION

Yıl 2022, , 211 - 215, 24.03.2022

Bilger Çavuş , Aslı Çifcibaşı Örmeci , Sami Evirgen , Raim İliaz Alp Atasoy , Gülçin Yeğen Kadir Demir Selman Fatih Beşışık , Sabahattin Kaymakoglu , Filiz Akyüz

https://doi.org/10.26650/IUITFD.1003753

Öz

Objective: In our study, we aimed to evaluate the prevalence of Helicobacter pylori (H. Pylori) and the characteristics of antrum pathologies in patients with portal hypertensive gastropathy. Materials and Methods: Antrum pathologies and the presence of H. Pylori evaluated with Giemsa stain in gastroscopies of 203 patients with portal hypertensive gastropathy. Results: A total of 203 patients, 119 male, 84 female, with portal hypertensive gastropathy was included in our study. In patients with portal hypertension, the rate of H. Pylori positivity was 15.3%. This rate was determined as 18.5% under 65 years old and 8.8% over 65 years old. On the basis of gender, H. Pylori positivity rates were 21.8% in male patients and 6% in female patients. The most common antrum pathologies in the patients, in order of frequency, were reactive gastropathy with a rate of 41.4%, active gastritis with a rate of 23.6%, and edema with a rate of 22.2%. The rate of intestinal metaplasia was found to be 9.9%. Conclusion: In the patients with portal hypertension included in our study, the H. Pylori positivity rate was found to be 15.3%. This rate was found to be below the H. Pylori positivity rate in our country. The most common antrum pathology in the patients was reactive gastropathy with a rate of 41.4%, while the rate of intestinal metaplasia was found to be 9.9%.

Anahtar Kelimeler

Portal hypertensive gastropathy, H. pylori, gastroscopy, prevelance

Destekleyen Kurum

Scientific Research Projects Coordination Unit of Istanbul University.

Proje Numarası

37697

PORTAL HİPERTANSİYONU OLAN HASTALARDA HELİCOBACTER PYLORİ SIKLIĞININ VE MİDE ANTRUM PATOLOJİ BULGULARININ DEĞERLENDİRİLMESİ

Öz

Amaç: Çalışmamızda portal hipertansif gastropatisi (PHG) olan hastalarda Helicobacter pylori sıklığını ve antrum patolojilerinin özelliklerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Portal hipertansiyonu olan 203 hastanın endoskopi ünitemizde yapılmış olan gastroskopilerinde portal hipertansif gastropati saptanan hastaların antrum patolojileri ve Giemsa boyası ile değerlendirilen H. Pylori varlığı retrospektif olarak araştırılmıştır. Bulgular: Çalışmaya, portal hipertansif gastropatisi olan, 119’u erkek, 84’ü kadın, toplam 203 hasta dahil edilmiştir. Portal hipertansif gastropatisi olan hastalarda, H. Pylori pozitiflik oranı %15,3 olarak saptandı. Bu oran 65 yaş altında %18,5, 65 yaş üzerinde ise %8,8 olarak saptanmıştır. Cinsiyet bazında, H. Pylori pozitiflik oranları erkek hastalarda %21,8, kadın hastalarda %6 olarak tespit edildi. Hastalarda en sık görülen antrum patolojileri sıklık sırasına göre: %41,4 oranı ile reaktif gastropati, %23,6 aktif gastrit ve %22,2’lik oran ile ödem olarak saptandı. İntestinal metaplazi oranı ise %9,9 olarak saptandı. Sonuç: Çalışmamıza dahil ettiğimiz PHG’i olan hastalarda, H. Pylori pozitiflik oranı %15,3 olarak saptandı. Bu oranın ülkemiz genelindeki H. Pylori pozitiflik oranının altında olduğu görülmüştür. Hastalarda en sık görülen antrum patolojisi %41,4 oranı ile reaktif gastropati iken, intestinal metaplazi oranı %9,9 olarak saptandı.

Anahtar Kelimeler

Portal Hipertansif Gastropati (PHG), H. Pylori, gastroskopi, prevelans

Proje Numarası

37697

Kaynakça

• 1. Feldman M, Freidman LS, Brandt LJ. Editors Sleisenger and Fordtran’s Gastrointestinal and Liver Disease Pathophysiology/ Diagnosis/ Management Volume 1 Eleventh Edition 2021; p. 801-
• 2. Franchis R. Faculty Expanding consensus in portal hypertension Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol 2015;63(3):743-52. [CrossRef]
• 3. Gjeorgjievski M, Cappell MS. Portal hypertensive gastropathy: A systematic review of the pathophysiology, clinical presentation, natural history and therapy. World J Hepatol 2016;8(4):231-62. [CrossRef]
• 4. Vaishnavi B, Kate V, Ananthakrishnan N. Prevalence of Helicobacter pylori in patients with portal hypertensive gastropathy - a study from south India. Med Sci Monit 2004;10(4):CR133-6.
• 5. Ohta M, Yamaguchi S, Gotoh N, Tomikawa M. Pathogenesis of portal hypertensive gastropathy: a clinical and experimental review. Surgery 2002;131(1 Suppl):S165-70. [CrossRef]
• 6. Payen JL, Cales P, Pienkowski P, Sozzani P, Kervran A, Frexinos J. et al. Weakness of mucosal barrier in portal hypertensive gastropathy of alcoholic cirrhosis. Effects of propranolol and enprostil. J Hepatol 1995;23(6):689-96. [CrossRef]
• 7. Kao CY, Sheu BS, Wu JJ. Helicobacter pylori infection: An overview ofbacterial virulence factors and pathogenesis. Biomed J 2016;39(1):14-23. [CrossRef]
• 8. Rossez Y, Gosset P, Boneca IG, Magalhães A, Ecobichon C, Reis CA, et al. The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa. J Infect Dis 2014;210(8):1286-95. [CrossRef]
• 9. Mao T, Wang Y, Yin F, Zhao Q, Yang L, Ding X, et al. Association of endoscopic features of gastric mucosa with Helicobacter pylori infection in Chinese patients. Gastroenterol Res Pract 2016;2016:6539639. [CrossRef]
• 10. Zaigham A, Yakoob J, Usman MW, Shakir T, Hamid S, Jafri W. Effect of Helicobacter pylori and its virulence factors on portal hypertensive gastropathy and interleukin (IL)- 8, IL-10, and tumor necrosis factor-alpha levels. Saudi J Gastroenterol 2014;20(2):120-7. [CrossRef]
• 11. Özaydın N, Türkyılmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13C-Urea breath test. BMC Public Health 2013;13:1215. [CrossRef]
• 12. Korkmaz M, Sadıç M, Koca G, Demirel K, Atılgan Hİ, Özyurt S, et al. Helicobacter Pylori Enfeksiyonunun Demografik, Sosyoekonomik ve Çevresel Faktörler ile İlişkisi: Ankara Hastanesi Deneyimi Kafkas J Med Sci 2013;3(2):74-9. [CrossRef]
• 13. Karadağ M, Ünsal B, Yörük G, Akyol Z, Sadun Koşay S. Sirozlu hastalarda portal gastropati ve helicobacter pylori enfeksiyonu sıklığı. Türkiye Klinikleri J Gastroenterohepatol 1999;10(1):1-5.
• 14. Mc Cormack TT, Sims J, Eyre-Brook I. Gastric lesion in portal hypertension: Inflammatory gastritis or congestive gastropathy? Gut 1985;26(11):1226-32. [CrossRef]
• 15. Abbasi A, Bhutto AR, Butt N, Munir SM, Dhillo AK. Frequency of portal hypertensive gastropathy and its relationship with biochemical, haematological and endoscopic features in cirrhosis. J Coll Physicians Surg Pak 2011;21(12):723-6.
• 16. Sathar SA, Kunnathuparambil SG, Sreesh S, Narayanan P, Vinayakumar KR. Helicobacter pylori infection in patients with liver cirrhosis: prevalence and association with portal hypertensive gastropathy. Ann Gastroenterol 2014;27(1):48-52.
• 17. Puri S, Jain M, Narayan KS, Pandey S, Nijhawan S. Helicobacter pylori infection in patients with portal hypertensive gastropathy owing to liver cirrhosis: Prevalence and relation with severity of gastropathy. J Dig Endosc 2017;8(3):123-8. [CrossRef]
• 18. Elsebaey MA, Tawfik MA, Elshweikh SA, Negm MS, Elnaggar MH, Alghazaly GH, et al. Impact of Helicobacter pylori Infection on Gastric Variceal Bleeding among Patients with Liver Cirrhosis. Gastroenterol Res Pract 2019;2019:6529420. [CrossRef]
• 19. Chandanwale SS, Gupta N, Sheth J, Naragude P, Gambhir AS, Pathak P, et al. Histopathological study of portal hypertensive gastropathy using gastric biopsy. Med J DY Patil Vidyapeeth 2017;10(6):562-7.