SİRİNJİK ASİDİN ANKSİYOLİTİK BENZERİ ETKİLERİ: DAVRANIŞ ÇALIŞMASI

Öz

Amaç: Bu çalışma, davranış testlerine tabi tutulan sıçanlarda deltametrin (DTM) maruziyetine karşı sirinjik asit (SA) uygulamasının olası anksiyolitik benzeri etkilerini araştırmak için yapılmıştır.
Gereç ve Yöntem: 250-270 gr ağırlığındaki Wistar albino erkek sıçanlar randomize olarak kontrol (0.5 mg/kg mısır yağı), DTM (1,28 mg/kg), SA (25 mg/kg) ve DTM+SA (1,28 mg/kg DTM, 25 mg/kg SA) olmak üzere dört gruba ayrıldı. Anksiyete benzeri davranışlar açık alan testi ve misket gömme testi (Noldus Ethovi- sion System) ile değerlendirildi.
Bulgular: Sirinjik asit tedavisi ile açık alan testinde, iç kısımda geçirilen süre (100,36±0,04 sn, F(3.36)=71,13, η2=0,877, p=0,0001; p<0,05), merkezdeki geçiş sayısı (21,42±1,23 (n), F(3.36)=13,13, η2=0,522, p=0,0056; p<0,05) ve dışkı skorlarında (2,9±0.21 (n), F(3.36)=51,51, η2=0,811; p<0,05) anlamlı farklılık ortaya çıktı. SA tedavisi misket gömme testinde diğer gruplara göre anlamlı bir farklılık gösterdi (F(3.36)=77,64, η2=0,962; p<0,0001).
Sonuçlar: Bu çalışmanın bulguları SA’nın anksiyolitik etkileri üzerine ilk adımı temsil ediyor ve sonuçlarımız SA tedavisinin anksiyete ile ilişkili bozukluklar için faydalı olabileceğini gösteriyor. Bu nedenle SA, altta yatan anksiyete bozukluklarının anlaşılmasını artırmak için yeni bir ilaç tasarımında değerlendirilmelidir ve DTM, Wistar sıçanlarında anksiyete davranışını modellemek için iyi bir kaynak olabilir.

Anahtar Kelimeler

• Açık alan testi
• anksiyete
• davranış
• misket gömme testi
• sirinjik asit

ANXIOLYTIC-LIKE EFFECTS OF SYRINGIC ACID: A BEHAVIORAL STUDY

Öz

Objective: The current study investigated the possible anxiolytic-like effects of syringic acid (SA) administration against deltamethrin (DTM) exposure in rats subjected to behavioral tests.
Materials and Methods: Wistar albino male rats weighing 250- 270 g were randomly divided into four groups as control (0.5 mg/kg corn oil), DTM (1.28 mg/kg), SA (25 mg/kg) and DTM+SA groups (1.28 mg/kg DTM, 25 mg/kg SA). Anxiety-like behaviors were evaluated by an open field test and a marble-burying test (Noldus Ethovision System).
Results: The SA treatment revealed a significant effect on time spent in the inner zone (100.36±0.04 sec, F(3.36)=71.13, η2=0.877, p=0.0001, p<0.05), number of crossings in the center (21.42±1.23 (n), F(3.36)=13.13, η2=0.522, p=0.0056, p<0.05) and fecal scores (2.9±0.21(n), F(3.36)=51.51, η2=0.811, p<0.05) via the open field. SA treatment exhibited a significant difference in the marble test compared with the other groups (F(3.36)=77.64, η2=0.962, p<0.0001).
Conclusions: The findings of this study represent the first step toward understanding the anxiolytic effects of SA, and our results suggest that SA treatment may be beneficial for anxiety-related disorders. Therefore, SA should be evaluated in a new drug design to increase the understanding of underlying anxiety disorders, and DTM may be a good resource for modeling anxiety behavior in Wistar rats.

Anahtar Kelimeler

• Syringic acid
• Anxiety
• behavior
• marble test
• open field test

Kaynakça

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