AKNE VULGARİSTE ENDOTELİN-1/NİTRİK OKSİT DENGESİ

Öz

Amaç: Akne vulgaris’te plazma ET-1 ve NOx (nitrik oksidin metabolitleri olan nitrat/nitrit) konsantrasyon düzeylerini tayin etmek, ayrıca bu iki parametre ve hastalığın derecesi arasında bir ilişki olup olmadığını incelemek. Gereç ve yöntem: Akne vulgaris tanısı konmuş 30 hasta ile 20 sağlıklı kişinin plazma örneklerinde ET-1 ve NOx ölçümlendi. Bulgular: Akne vulgarisli hastalarda kontrol grubuna göre plazma ET-1 ve NOx düzeyleri anlamlı (p < 0,01) bir artış gösterdi. Kontrol grubunda ET-1 ve NOx arasında zayıf, fakat anlamlı bir negatif korelasyon (r= -0,456, p < 0,05) bulundu. Çalışma grubunda ise ET-1 ve NOx düzeyleri arasında bir korelasyon bulunmadı (r= -0,195, p= 0,302). Ayrıca, çalışma grubunda ET-1, NOx düzeyleri ve hastalık süresi arasında anlamlı korelasyonlar (r= 0,412, p < 0,05 ve r= 0,570, p < 0,01) olduğu gözlendi. Akne lezyonlarının derecesi ve ET-1, NOx düzeyleri arasında bir korelasyon bulunmadı. Sonuç:Akne vulgariste görülen plazma ET-1 ve NOx düzeylerindeki yükseliş muhtemelen artmış duktal hiperkornifikasyon, hiperkeratinizasyon ve sebum birikiminin sebebi ve/veya sonucu olabilir. Artmış olan ET-1 ve NOx üretimi keratinositlerde büyük olasılıkla büyüme, sitotoksik ve mitojenik factor gibi davranıyor olabilir. Çalışma grubunda ET-1 ve NOx arasında korelasyonun bulunmaması, akne lezyonlarının oluşmasına yol açan bu iki parametre arasındaki dengenin bozulduğunu yansıtmaktadır

Anahtar Kelimeler

• Acne vulgaris, endotelin-1, nitrik oksit

Kaynakça

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