EFFECT OF HYPERBARIC OXYGEN THERAPY ON FASTING BLOOD GLUCOSE AND INSULIN RESISTANCE

Öz

Objective: The subject of this study was to investigate the effect of hyperbaric oxygen (HBO2) therapy on fasting blood glucose levels and insulin resistance. The study investigated whether HBO2 therapy is effective in reducing peripheral insulin resis tance in patients with and without Diabetes Mellitus (DM) Material and Methods: The study included 27 patients with and without DM who received hyperbaric oxygen therapy at a pres sure of 2.4 ATA for 120 min per session, with 5-min air breaks ev ery 25 min, one session per day, five days a week, for 20 sessions. Patients were divided into two groups: those without DM and those with DM. Of the patients, 15 were without DM, while 12 were with DM. Glucose, C-Reactive protein (CRP), HbA1C, and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) values were compared at the beginning and end of treatment. Results: In repeated measurements, there was a statistically significant decrease in the mean fasting blood glucose levels in patients with DM. Patients without DM also showed a reduction in the mean fasting blood glucose levels in repeated measurements, but this decrease was not statistically significant. There was a statistically significant decrease in the mean C-peptide level in repeated measurements in patients with DM and the mean insulin level in repeated measurements in patients without DM. There was a statistically significant decrease in the HOMA-IR values calculated in repeated measurements in patients with and without DM. Conclusion: In our study, insulin resistance decreased in pa tients receiving HBO2 therapy. The fact that this decrease was also shown in patients without DM strengthens the idea that this decrease is related to HBO2 therapy. Further research is needed to gain a more comprehensive understanding of the therapeutic potential of HBO2 therapy in managing insulin resistance.

Anahtar Kelimeler

• Blood sugar level
• diabetes mellitus
• hyperbaric oxygen therapy
• insulin resistance

Teşekkür

Değerli katkılarından dolayı Ünal Tombulel'e teşekkür ederiz.

HİPERBARİK OKSİJEN TEDAVİSİNİN AÇLIK KAN ŞEKERİ VE İNSÜLİN DİRENCİ ÜZERİNDEKİ ETKİSİ

Öz

Amaç: Bu çalışmanın konusu hiperbarik oksijen (HBO2) tedavisi nin açlık kan şekeri düzeyleri ve insülin direnci üzerindeki etkisi dir. Çalışmanın amacı, HBO2 tedavisinin hem Diabetes Mellitus lu (DM) hem de DM olmayan hastalarda periferik insülin direncini azaltmada etkili olup olmadığını araştırmaktır. Gereç ve Yöntem: Diyabeti olan ve olmayan 27 hastaya hafta da beş gün, günde bir seans, seans başına 120 dakika süreyle, 2,4 ATA basınçta, her 25 dakikada bir 5 dakikalık hava molaları ile 20 seans hiperbarik oksijen tedavisi uygulanmıştır. Hastalar DM olmayanlar ve DM olanlar olmak üzere iki gruba ayrılmıştır. Hastaların 15'i diyabeti olmayan, 12'si ise tip 2 DM’liydi. Teda vinin başında ve sonunda glukoz, C-Reactive protein (CRP), HbA1C ve Homeostasis Model Assessment Insulin Resistance (HOMA-IR) değerleri karşılaştırıldı. Bulgular: Tekrarlanan ölçümlerde, diyabetli hastalarda ortalama açlık kan şekeri seviyelerinde istatistiksel olarak anlamlı bir düşüş görülmüştür. DM olmayan hastalarda da tekrarlanan ölçümlerde ortalama açlık kan şekeri seviyelerinde azalma görüldü, ancak bu azalma istatistiksel olarak anlamlı değildi. DM’li hastalarda tekrarlanan ölçümlerde ortalama C-peptid seviyesinde ve DM olmayan hastalarda tekrarlanan ölçümlerde ortalama insülin seviyesinde istatistiksel olarak anlamlı bir düşüş olmuştur. DM olan ve olmayan hastalarda tekrarlanan ölçümlerde hesaplanan HOMA-IR değerlerinde istatistiksel olarak anlamlı bir düşüş vardı. Sonuç: Çalışmamızda HBO2 tedavisi alan hastalarda insülin di renci azalmıştır. Bu azalmanın DM olmayan hastalarda da göste rilmiş olması, bu azalmanın HBO2 tedavisi ile ilişkili olduğu fikrini güçlendirmektedir. HBO2 tedavisinin insülin direncini yönetme deki terapötik potansiyelinin daha kapsamlı bir şekilde anlaşıl ması için daha fazla araştırmaya ihtiyaç vardır.

Anahtar Kelimeler

• Kan şekeri
• diyabet
• hiperbarik oksijen tedavisi
• insülin direnci

Teşekkür

Değerli katkılarından dolayı Ünal Tombulel'e teşekkür ederiz.

Kaynakça

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