INHERITANCE OF ACQUIRED EPIGENETIC MODIFICATIONS AND ITS ROLE IN DISEASE SUSCEPTIBILITY

Öz

Epigenetic mechanisms affect cellular gene expression levels independently from DNA sequence. Epigenetic modifications can cause heritable phenotypic changes by the influence of environmental factors such as toxicants, nutrition and stress. Specific epigenetic marks that escape embryonic epigenetic reprogramming may have a role in obesity, cancer and cardiovascular disease susceptibility through subsequent generations. Recent studies point out that epigenetic may be related with complex diseases with unknown etiopathology. In this review, we summarized the effects of environmental factors on epigenome, epigenetic inheritance mechanisms across generations and related pathologies.

Keywords: Epigenetic; environmental factors; disease susceptibility.

Anahtar Kelimeler

• Epigenetic,environmental factors,disease susceptibility

KAZANILMIŞ EPİGENETİK DEĞİŞİKLİKLERİN KALITIMI VE HASTALIKLARA YATKINLIKTAKİ ROLÜ

Öz

DNA dizisinden bağımsız olarak hücrede gen ifadesini değiştiren epigenetik düzenlemeler, toksik maddeler, beslenme ve stres gibi çevresel faktörlerin etkisiyle fenotipte kalıcı değişikliklere neden olabilmektedir. Embriyonik dönemde epigenetik yeniden programlamadan kaçan bazı epigenetik işaretler, sonraki jenerasyonlara aktarılarak obezite, kanser ve kardiyovasküler hastalıklara yatkınlığın oluşmasında rol oynamaktadır. Son yıllarda yapılan çalışmalar, epigenetiğin etyopatolojisi tam olarak açıklanamayan kompleks hastalıklar ile ilişkili olduğuna işaret etmektedir. Bu derlemede, çevresel faktörlerin epigenom üzerindeki etkileri, bu etkilerin jenerasyonlar boyu aktarım mekanizmaları ve ilişkili olduğu patolojiler özetlenecektir.

Anahtar Kelimeler: Epigenetik; çevresel etkenler; hastalıklara yatkınlık.

Anahtar Kelimeler

• Epigenetik,çevresel etkenler,hastalıklara yatkınlık

Kaynakça

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