ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ

Öz

Amaç: Deneysel ve epidemiyolojik çalışmalar, yüksek serum homosistein düzeylerinin renal hasara yol açabileceğini ve kronik böbrek hastalığı gelişimi için önemli bir risk faktörü olabileceğini göstermektedir. Çalışmamızın amacı IgA nefropatisi ve Henoch- Schönlein purpura nefriti olan hastalarda serum homosistein düzeyleri ile kresent oluşumu arasında bir ilişki olup olmadığını belirlemektir. Gereç ve Yöntemler: Üç pediatrik nefroloji merkezinde son beş yılda biyopsi ile IgA nefropatisi, Henoch-Schönlein purpura nefriti ve idiopatik kresentik glomerulonefrit tanısı alan 31 hasta ve 25 sağlıklı kontrol çalışmaya alındı. Bulgular: Hastaların homosistein düzeyleri normal değerin üst sınırından ve kontrollerden de daha yüksekti (p=0,0001). Biyopside kresent görülen ve görülmeyen hastalar arasında da homosistein düzeyleri açısından anlamlı fark yoktu (p>0,05). Proteinüri varlığı ve şiddeti ile homosistein düzeyleri arasında ilişki saptanmadı (p>0,05). Sonuç: Serum homosistein düzeyleri IgA nefropatisi ve Henoch- Schonlein purpura nefriti olan hastalarda yüksek bulunmuştur. Sonuçlarımız, bu hasta grubunda yüksek serum homosistein düzeylerinin segmental glomerüloskleroz ile ilişkili olabileceğini düşündürmektedir.

Anahtar Kelimeler

• IgA nefropatisi
• homosistein
• kresent

A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN

Öz

Objective: The evidences from experimental and epidemiological studies suggests that elevated serum homocysteine levels may lead to renal injury and may be a significant risk factor for the development of chronic kidney disease. The aim of this study was to investigate a possible relationship between serum homocysteine level and crescent formation in children with IgA nephropathy and Henoch-Schonlein purpura nephritis. Material and Methods: A total of 31 patients diagnosed as biopsy proven IgA nephropathy and Henoch-Schonlein purpura nephritis and idiopathic crescentic glomerulonephritis in three Pediatric Nephrology centers within the last five years and 25 healthy controls were enrolled in the study. Results: Homocysteine levels of patients were higher than the upper limit of normal value and also higher than the controls (p=0.0001). There was no significant difference between the patients with or without crescent formation regarding homocysteine levels (p>0.05). Presence or severity of proteinuria was not related to homocysteine levels (p>0.05). Conclusion: Serum homocysteine levels are elevated in patients with IgA nephropathy and Henoch-Schonlein purpura nephritis. Our results suggest that elevated serum homocysteine levels may be related to segmental glomerulosclerosis in these patient groups.

Anahtar Kelimeler

• IgA nephropathy
• homocysteine
• crescent

Kaynakça

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