VARİS KANAMASI OLAN SİROZ HASTALARINDA QTC İNTERVALİNİN DEĞERLENDİRİLMESİ

Öz

Amaç: Bu çalışmada QTc intervalinin siroz hastalarında meydana gelen özofagus varis kanamasının mortalite ve morbidite üzerindeki etkisi araştırıldı. Gereç ve Yöntem: Çalışma, retrospektif, tek merkezli yapıldı. Hastaların kanama öncesi ve kanama anındaki QTc intervalleri hesaplandı. Hastaların demografik özellikleri ve mortalite durumları kaydedildi. Bulgular: Yüz elli altı hastanın 117'sinde kanama saptandı. Bunların %83'ü erkek, %17'si kadındı. Kanama anında ölçülen QTc intervali kanama öncesi ölçülenden uzundu (p<0,001). Kanama nedeniyle ölen hastaların QTc süresi 509,9 ms olarak bulundu. Erkekler için hesaplanan QTc değeri 520,6 ms ve kadınlar için hesaplanan 487,4 ms idi. Mortalite açısından QTc için yapılan ROC analizinde, erkeklerde 464,0 ms için sensitivite %82,4 ve spesivite %79,7 olarak bulundu (AUC:0,785; 95% CI 0.724-0,825). Kadınlarda QTc’nin 454,0 ms, cutoff değeri için sensitivite %77,8 ve spesivite %90,0 olarak bulundu (AUC:856; 95% CI 0.812-0,862). Sonuç: Siroz tanısı olan hastalarda özofagus varis kanaması durumunda QTc intervali uzamaktadır. Uzamış QTc intervali hastaların mortalite ve morbiditesi ile ilişkilidir.

Anahtar Kelimeler

• Acil servis
• siroz
• QTc intervali
• varis kanaması

EVALUATION OF QTC INTERVAL IN CIRRHOSIS PATIENTS WITH VARICEAL HEMORRHAGE

Öz

Objective: In this study, we investigated the effect of the QTc interval in cirrhosis patients on mortality and morbidity in esophageal variceal hemorrhages. Material and Method: It was retrospectively scanned in a single- centred design. The QTC intervals before and during the bleeding were calculated. The demographic characteristics and mortality status were recorded. Results: Bleeding was detected in 117 of the 156 patients. A total of 83% of these were male, and 17% were female. The QTc interval in these patients measured at the time of bleeding was longer than that measured before bleeding (p<0.001). The QTc interval of the patients who died due to bleeding was found to be 509.9 ms. It was calculated for males as 520.6 ms, and 487.4 ms for females. In the ROC analysis that was conducted for the QTc in terms of mortality, the sensitivity was 82.4% and specificity was 79.7% for 464.0 ms in males (AUC:0.785; 95% CI 0.724-0.825). The sensitivity was 77.8% and the specificity was 90.0% for QTc’s 454.0 ms cutoff value for females (AUC:856; 95% CI 0.812-0.862). Conclusion: The QTc interval is prolonged in the case of esophageal variceal hemorrhage in patients diagnosed with cirrhosis. A prolonged QTc interval is associated with mortality and morbidity of patients.

Anahtar Kelimeler

• Emergency department
• cirrhosis
• QTc interval
• variceal hemorrhage

Kaynakça

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