Yıl 2019, Cilt 82 , Sayı 3, Sayfalar 131 - 138 2019-07-16

STAPHYLOCOCCUS AUREUS BAKTERİYEMİLERİNDE MORTALİTE RİSK FAKTÖRLERİNİN ANALİZİ: SEFAZOLİN DAHA İYİ SONUÇLA İLİŞKİLİ
ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME

Seniha BAŞARAN [1] , Serap ŞİMŞEK YAVUZ [2] , Betül SADIÇ ÇOPUR [3] , Asiye YİR [4] , Atahan ÇAĞATAY [5] , Oral ÖNCÜL [6] , Halit ÖZSÜT [7] , Haluk ERAKSOY [8]


Amaç: Metisiline duyarlı Staphylococcus aureus (MSSA), önemli bir bakteriyemi etkeni olup, hastalarda ciddi mortaliteye neden olur. Bu çalışmada, toplum kaynaklı (TK) veya sağlık bakımı (SB)’yla ilişkili MSSA bakteriyemilerinde mortaliteye etki eden risk faktörlerinin belirlenmesi amaçlanmıştır. Ayrıca MSSA bakteriyemilerinin tedavi seçeneklerinden sefazolin ve özellikle ampisilin-sulbaktam olmak üzere diğer antimikrobiklerin tedavideki yeterlikleri karşılaştıırlmıştır. Gereç ve Yöntem: 2009-2014 yılları arasında hastanemizde yatarak tedavi edilen ve MSSA bakteriyemisi tanısı konulan erişkin hastalar çalışmaya dahil edildi. TK veya SB ilişkili MSSA bakteriyemisi olan hastalar karşılaştırıldı. Bulgular: Toplam 127 MSSA bakteriyemili hastanın %83’ü SB ile ilişkiliydi. Mortalite oranı %20,5 olup, TK ve SB MSSA bakteriyemili hastalar arasında fark yoktu. Çok değişkenli analizde yüksek komorbidite indeksi (HR 1,557), metastatik infeksiyon odağı varlığı (HR 2,883) ve yoğun bakım desteğine ihtiyacın olması (HR 16,239) mortalite için bağımsız risk faktörleri, tedavide sefazolin kullanımı ise mortaliteyi azaltan bir faktör olarak saptandı (HR 0,178). Sonuç: Diğer antimikrobiyallerle karşılaştırıldığında sefazolinle tedavi edilen MSSA bakteriyemilerinde klinik sonuçlar daha iyi belirlendiği için, özellikle antistafilokoksik penisilinlerin bulunmadığı yerlerde veya bu ajanları tolere edemeyen hastalarda diğer antimikrobiklerin yerine sefazolin tercih edilmelidir.
Objective: Methicillin-sensitive Staphylococcus aureus (MSSA) is frequent cause of bacteraemias and associated with substantial mortality. We defined risk factors for mortality among patients with either community-acquired (CA) or healthcare-associated (HCA) MSSA bacteraemia with special emphasis on treatment options including cefazolin and other antimicrobials (mainly ampicillin-sulbactam). Material and Method: All adult patients who were hospitalized and whose blood cultures were positive for MSSA between 2009 and 2014 were included. Patients with CA and HCA MSSA bacteraemia were compared. Results: 83% of the 127 patients with MSSA bacteraemia had HCA. The mortality rate of patients was 20.5% and this did not differ between patients with either CA or HCA MSSA bacteraemia. In the multivariate analysis, higher comorbidity index (HR 1.557), presence of metastatic foci (HR 2.883), and requirement for ICU support (HR 16.239) were found as independent risk factors for mortality, and cefazolin use was found to be protective against mortality (HR 0.178). Conclusion: Patients with MSSA bacteraemia should be treated with cefazolin instead of other antimicrobial options, especially in countries where anti-staphylococcal penicillins are not available or in patients who cannot tolerate anti-staphylococcal penicillins, as cefazolin was found to be protective against mortality
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Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm ARAŞTIRMA
Yazarlar

Orcid: 0000-0002-3402-2510
Yazar: Seniha BAŞARAN (Sorumlu Yazar)

Orcid: 0000-0002-4675-169X
Yazar: Serap ŞİMŞEK YAVUZ

Orcid: 0000-0001-5534-1388
Yazar: Betül SADIÇ ÇOPUR

Orcid: 0000-0001-9473-5099
Yazar: Asiye YİR

Orcid: 0000-0002-3051-8199
Yazar: Atahan ÇAĞATAY

Orcid: 0000-0002-1681-1866
Yazar: Oral ÖNCÜL

Orcid: 0000-0002-5222-9320
Yazar: Halit ÖZSÜT

Orcid: 0000-0002-5790-0806
Yazar: Haluk ERAKSOY

Tarihler

Yayımlanma Tarihi : 16 Temmuz 2019

Bibtex @araştırma makalesi { iuitfd571535, journal = {Journal of Istanbul Faculty of Medicine}, issn = {}, eissn = {1305-6441}, address = {}, publisher = {İstanbul Üniversitesi}, year = {2019}, volume = {82}, pages = {131 - 138}, doi = {10.26650/IUITFD.2019.0009}, title = {ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME}, key = {cite}, author = {BAŞARAN, Seniha and ŞİMŞEK YAVUZ, Serap and SADIÇ ÇOPUR, Betül and YİR, Asiye and ÇAĞATAY, Atahan and ÖNCÜL, Oral and ÖZSÜT, Halit and ERAKSOY, Haluk} }
APA BAŞARAN, S , ŞİMŞEK YAVUZ, S , SADIÇ ÇOPUR, B , YİR, A , ÇAĞATAY, A , ÖNCÜL, O , ÖZSÜT, H , ERAKSOY, H . (2019). ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME. Journal of Istanbul Faculty of Medicine , 82 (3) , 131-138 . DOI: 10.26650/IUITFD.2019.0009
MLA BAŞARAN, S , ŞİMŞEK YAVUZ, S , SADIÇ ÇOPUR, B , YİR, A , ÇAĞATAY, A , ÖNCÜL, O , ÖZSÜT, H , ERAKSOY, H . "ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME". Journal of Istanbul Faculty of Medicine 82 (2019 ): 131-138 <https://dergipark.org.tr/tr/pub/iuitfd/issue/46082/571535>
Chicago BAŞARAN, S , ŞİMŞEK YAVUZ, S , SADIÇ ÇOPUR, B , YİR, A , ÇAĞATAY, A , ÖNCÜL, O , ÖZSÜT, H , ERAKSOY, H . "ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME". Journal of Istanbul Faculty of Medicine 82 (2019 ): 131-138
RIS TY - JOUR T1 - ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME AU - Seniha BAŞARAN , Serap ŞİMŞEK YAVUZ , Betül SADIÇ ÇOPUR , Asiye YİR , Atahan ÇAĞATAY , Oral ÖNCÜL , Halit ÖZSÜT , Haluk ERAKSOY Y1 - 2019 PY - 2019 N1 - doi: 10.26650/IUITFD.2019.0009 DO - 10.26650/IUITFD.2019.0009 T2 - Journal of Istanbul Faculty of Medicine JF - Journal JO - JOR SP - 131 EP - 138 VL - 82 IS - 3 SN - -1305-6441 M3 - doi: 10.26650/IUITFD.2019.0009 UR - https://doi.org/10.26650/IUITFD.2019.0009 Y2 - 2019 ER -
EndNote %0 İstanbul Tıp Fakültesi Dergisi ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME %A Seniha BAŞARAN , Serap ŞİMŞEK YAVUZ , Betül SADIÇ ÇOPUR , Asiye YİR , Atahan ÇAĞATAY , Oral ÖNCÜL , Halit ÖZSÜT , Haluk ERAKSOY %T ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME %D 2019 %J Journal of Istanbul Faculty of Medicine %P -1305-6441 %V 82 %N 3 %R doi: 10.26650/IUITFD.2019.0009 %U 10.26650/IUITFD.2019.0009
ISNAD BAŞARAN, Seniha , ŞİMŞEK YAVUZ, Serap , SADIÇ ÇOPUR, Betül , YİR, Asiye , ÇAĞATAY, Atahan , ÖNCÜL, Oral , ÖZSÜT, Halit , ERAKSOY, Haluk . "ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME". Journal of Istanbul Faculty of Medicine 82 / 3 (Temmuz 2019): 131-138 . https://doi.org/10.26650/IUITFD.2019.0009
AMA BAŞARAN S , ŞİMŞEK YAVUZ S , SADIÇ ÇOPUR B , YİR A , ÇAĞATAY A , ÖNCÜL O , ÖZSÜT H , ERAKSOY H . ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME. İst Tıp Fak Derg. 2019; 82(3): 131-138.
Vancouver BAŞARAN S , ŞİMŞEK YAVUZ S , SADIÇ ÇOPUR B , YİR A , ÇAĞATAY A , ÖNCÜL O , ÖZSÜT H , ERAKSOY H . ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME. Journal of Istanbul Faculty of Medicine. 2019; 82(3): 138-131.