Yıl 2019, Cilt 82 , Sayı 3, Sayfalar 162 - 163 2019-07-16

ŞİZOFRENİDE TEDAVİYE DİRENÇ NEDENİ OLARAK GENETİK SENDROMLAR: TRİPLE X SENDROMLU BİR OLGU
GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME

Bahadır TURAN [1] , Mehmet Akif AKINCI [2] , İbrahim Selçuk ESİN [3] , Onur Burak DURSUN [4]


Amaç: Triple X sendromu (47, XXX), kadınlarda ekstra bir X kromozomunun varlığı ile karakterize, 1/1.000 kişide bir görülen bir sendromdur. Trizomi X, değişken şiddette bilişsel ve davranışsal özelliklerle karakterize bir kromozomal hastalıktır. Bu olgu sunumunda; Triple X sendromlu ve dirençli şizofreni tanısı alan 16 yaşında bir vaka sunuyoruz. Genetik sendromların psikiyatrik problemlerin tedavisinde tedaviye dirençle ilişkili olabileceği ve bu nedenle tedaviye dirençli olgularda genetik analizlerin mutlaka yapılması gerektiği göz önünde bulundurulmalıdır. 
Triple X syndrome (47, XXX) is a numerical chromosomal alteration that affects 1/1.000 females, in which the individual is born with an extra X chromosome. Trisomy X is a relatively common but under- recognized chromosomal disorder associated with characteristic cognitive and behavioural features of varying severity. We report a 16-year old patient with Triple X syndrome and resistant schizophrenia. It is remarkable that genetic syndromes may be associated with resistance to treatment of psychiatric problems. Therefore in cases with treatment resistance, the genetic analysis should absolutely be examined. 
  • 1. Afshan A. Triple X syndrome. J Pak Med Assoc 2012;62(4):392.
  • 2. Woodhouse WJ, Holland AJ, McLean G, Reveley AM. The association between triple X and psychosis. Br J Psychiatry. 1992;160(4):554-7.
  • 3. Otter M, Schrander-Stumpel CT, Curfs LM. Triple X syndrome: a review of the literature. Eur J Hum Genet. 2010;18(3):265.
  • 4. Lenroot RK, Blumenthal JD, Wallace GL, Clasen LS, Lee NR, Giedd JN. A case-control study of brain structure and behavioral characteristics in 47, XXX syndrome. Genes Brain Behav. 2014;13(8):841-9.
Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Olgu Sunumu
Yazarlar

Orcid: 0000-0003-1190-9589
Yazar: Bahadır TURAN

Orcid: 0000-0002-6436-4394
Yazar: Mehmet Akif AKINCI
Kurum: ATATÜRK ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0001-5598-2097
Yazar: İbrahim Selçuk ESİN (Sorumlu Yazar)
Kurum: ATATÜRK ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0003-2990-9851
Yazar: Onur Burak DURSUN

Tarihler

Yayımlanma Tarihi : 16 Temmuz 2019

Bibtex @olgu sunumu { iuitfd584808, journal = {Journal of Istanbul Faculty of Medicine}, issn = {}, eissn = {1305-6441}, address = {}, publisher = {İstanbul Üniversitesi}, year = {2019}, volume = {82}, pages = {162 - 163}, doi = {10.26650/IUITFD.2019.0011}, title = {GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME}, key = {cite}, author = {TURAN, Bahadır and AKINCI, Mehmet Akif and ESİN, İbrahim Selçuk and DURSUN, Onur Burak} }
APA TURAN, B , AKINCI, M , ESİN, İ , DURSUN, O . (2019). GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME. Journal of Istanbul Faculty of Medicine , 82 (3) , 162-163 . DOI: 10.26650/IUITFD.2019.0011
MLA TURAN, B , AKINCI, M , ESİN, İ , DURSUN, O . "GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME". Journal of Istanbul Faculty of Medicine 82 (2019 ): 162-163 <https://dergipark.org.tr/tr/pub/iuitfd/issue/46082/584808>
Chicago TURAN, B , AKINCI, M , ESİN, İ , DURSUN, O . "GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME". Journal of Istanbul Faculty of Medicine 82 (2019 ): 162-163
RIS TY - JOUR T1 - GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME AU - Bahadır TURAN , Mehmet Akif AKINCI , İbrahim Selçuk ESİN , Onur Burak DURSUN Y1 - 2019 PY - 2019 N1 - doi: 10.26650/IUITFD.2019.0011 DO - 10.26650/IUITFD.2019.0011 T2 - Journal of Istanbul Faculty of Medicine JF - Journal JO - JOR SP - 162 EP - 163 VL - 82 IS - 3 SN - -1305-6441 M3 - doi: 10.26650/IUITFD.2019.0011 UR - https://doi.org/10.26650/IUITFD.2019.0011 Y2 - 2019 ER -
EndNote %0 İstanbul Tıp Fakültesi Dergisi GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME %A Bahadır TURAN , Mehmet Akif AKINCI , İbrahim Selçuk ESİN , Onur Burak DURSUN %T GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME %D 2019 %J Journal of Istanbul Faculty of Medicine %P -1305-6441 %V 82 %N 3 %R doi: 10.26650/IUITFD.2019.0011 %U 10.26650/IUITFD.2019.0011
ISNAD TURAN, Bahadır , AKINCI, Mehmet Akif , ESİN, İbrahim Selçuk , DURSUN, Onur Burak . "GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME". Journal of Istanbul Faculty of Medicine 82 / 3 (Temmuz 2019): 162-163 . https://doi.org/10.26650/IUITFD.2019.0011
AMA TURAN B , AKINCI M , ESİN İ , DURSUN O . GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME. İst Tıp Fak Derg. 2019; 82(3): 162-163.
Vancouver TURAN B , AKINCI M , ESİN İ , DURSUN O . GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME. Journal of Istanbul Faculty of Medicine. 2019; 82(3): 163-162.