Araştırma Makalesi
BibTex RIS Kaynak Göster

IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL

Yıl 2021, Cilt: 84 Sayı: 2, 197 - 207, 25.04.2021
https://doi.org/10.26650/IUITFD.2020.0065

Öz

Objective: In this experimental work, we aimed to compare the efficacy of two different methods of combining the mucoperiosteal flaps in an animal model: using a tissue adhesive material N-butyl-2-cyanoacrylate (Glubran®2) and the classical suturing technique in cleft palate surgery. Methods: Rats were separated into group A and B. In group A (n=12) mucoperiosteal flaps were brought together with absorbable suturing material, while in group B (n=12), adhesive material was used for the same purpose. Palatal mucosa healing was evaluated histologically in terms of inflammatory cell infiltration, fibroblastic activity and vascularization on the postoperative 8th and 16th days. Results: As a result of this experimental study, there were no differences macroscopically in palatal mucosa healing in both groups. Histologically, on day 8, the inflammation severity was higher in the suture material group and the difference was statistically significant. On day 16, fibroblastic activity was significantly lower in the suture material group. There was no significant difference between the groups in terms of vascularity. Conclusion: As a result of these findings, Glubran®2 was found to be easily usable and effective with low complication rates, moreover, it was a practical tissue adhesive material for merging mucosal flaps in the midline of the palate.

Kaynakça

  • 1. Levi B, Brugman S, Wong VW, Grova M, Longaker MT, Wan DC. Palatogenesis: Engineering, pathways and pathologies. Organogenesis 2011;7(4):242-54. [CrossRef]
  • 2. Kosowski TR, Weathers WM, Wolfswinkel EM, Al. E. Cleft palate. Semin Plast Surg. 2009;26(4):164-9. [CrossRef]
  • 3. Hwang K, Lee JH, Kim YJ, Le S Il. Palatoplasty: Suturing the mucoperiosteal flaps to the hard palate through hole. J Craniofac Surg 2009;20(3):916-7. [CrossRef]
  • 4. Vastani A, Maria A. Healing of intraoral wounds closed using silk sutures and isoamyl 2-cyanoacrylate glue: A comparative clinical and histologic study. J Oral Maxillofac Surg 2013;71(2):241-8. [CrossRef]
  • 5. Öztürk H, Öztürk H, Duran H, Okur H. The Use of Glubran 2 in Management of Cleft Palate. Düzce Tıp Fakültesi Derg 2008;3:29-31.
  • 6. Turkaslan T, Ozcan H, Dayicioglu D, Ozsoy Z. Use of adhesives in cleft palate surgery:a new flap fixation technique. J Craniofac Surg 2005;4:719-22. [CrossRef]
  • 7. Kumar MS, Natta S, Shankar G, Reddy SHK, Visalakshi D, Seshiah G V. Comparison between Silk Sutures and Cyanoacrylate Adhesive in Human Mucosa- A Clinical and Histological Study. J Int oral Health 2013;5(5):95-100.
  • 8. Quinn JV, Osmond MH, Yurack JA, Moir PJ. N-2- butylcyanoacrylate: risk of bacterial contamination with an appraisal of its antimicrobial effects. J Emerg Med 1995;13(4):581-5. [CrossRef]
  • 9. Montanaro L, Arciola CR, Cenni E, Ciapetti G, Savioli F, Filippini F, et al. Cytotoxicity, blood compatibility and antimicrobial activity of two cyanoacrylate glues for surgical use. Biomaterials 2000;22(1):59-66. [CrossRef]
  • 10. Kull S, Martinelli I, Briganti E, Losi P, Spiller D, Tonlorenzi S, et al. Glubran®2 Surgical Glue: In Vitro Evaluation of Adhesive and Mechanical Properties. J Surg Res 2009;157(1):e15-21. [CrossRef]
  • 11. Wijdeveld MGMM, Maltha JC, Grupping EM, De Jonge J, Kuijpers-Jagtman AM. A histological study of tissue response to simulated cleft palate surgery at different ages in Beagle dogs. Arch Oral Biol 1991;36(11):837-43. [CrossRef]
  • 12. In de Braekt MMH, Alphen FAM V, Kuijpers-Jagtman AM, Maltha JC. Wound Healing and Wound Contraction After Palatal Surgery and Implantation of Poly-(L-Lactic) Acid Membranes in Beagle Dogs. J Oral Maxillofac Surg 1992;50:359-64. [CrossRef]
  • 13. Gökmen Z, MD. Effects of Hyaluronic Acid After the Cleft Palate Operation on the Growth of Maxilla in a Rat Model Cleft. Uludağ University, Department of Plastic Reconstructive and Aesthetic Surgery Aesthetic Surgery, Master Thesis. Uludağ University; 2012.

IN VIVO MODELDE YARIK DAMAK CERRAHİSİNDE N-BUTİL-2-SİYANOAKRİLATIN KULLANIMI VE ETKİNLİĞİNİN SÜTÜR MATERYALİ İLE KARŞILAŞTIRILMASI

Yıl 2021, Cilt: 84 Sayı: 2, 197 - 207, 25.04.2021
https://doi.org/10.26650/IUITFD.2020.0065

Öz

Amaç: Bu deneysel çalışma, mukozal yapılarda etkili olan bir çeşit doku yapıştırıcısı olan N-butil-2-siyanoakrilatın (Glubran®2) hayvan modelinde damak onarımında etkinliğini kanıtlamak ve damak mukoza iyileşmesinde sütür materyali ile bu yapıştırıcının etkinliğini karşılaştırmak amacıyla yapılmıştır. Gereç ve Yöntem: Sıçanlar iki ana gruba ayrıldı. Grup A’da (n=12) mukoperiosteal flepler sütür materyali ile bir araya getirilirken, grup B’de (n=12) mukoperiosteal flepler doku yapıştırıcı ile biraraya getirildi. Damak mukoza iyileşmesi, histolojik olarak, inflamatuar hücre infiltrasyonu, fibroblastik aktivite ve vaskülarizasyona bakılarak, postop 8. gün ve 16. günde değerlendirildi. Bulgular: Bu çalışmanın sonucunda; dikiş materyaliyle doku yapıştırıcısı arasında makroskobik bir fark saptanamamıştır. Histolojik olarak, 8. günde, dikiş grubunda inflamasyon şiddetinin istatistiksel olarak anlamlı şekilde yüksek olduğu görüldü. Dikiş grubunda 16. günde, fibroblastik aktivitenin istatistiksel olarak anlamlı miktarda düşük olduğu görüldü. Vaskülarite açısından, iki grup arasında benzer değerler görüldü. Sonuç: Bu bulgular neticesinde, N-butil-2 siyanoakrilat’ın yarık damak cerrahisinde, mukozal fleplerin orta hatta tespitinde (sütür tekniklerinin uygulanması zor olan bu dar cerrahi sahada) kolay uygulanabilen, etkin ve komplikasyon oranı düşük, cerrah açısından zaman kaybı yaratmayacak bir materyal olabileceği sonucuna varıldı.

Kaynakça

  • 1. Levi B, Brugman S, Wong VW, Grova M, Longaker MT, Wan DC. Palatogenesis: Engineering, pathways and pathologies. Organogenesis 2011;7(4):242-54. [CrossRef]
  • 2. Kosowski TR, Weathers WM, Wolfswinkel EM, Al. E. Cleft palate. Semin Plast Surg. 2009;26(4):164-9. [CrossRef]
  • 3. Hwang K, Lee JH, Kim YJ, Le S Il. Palatoplasty: Suturing the mucoperiosteal flaps to the hard palate through hole. J Craniofac Surg 2009;20(3):916-7. [CrossRef]
  • 4. Vastani A, Maria A. Healing of intraoral wounds closed using silk sutures and isoamyl 2-cyanoacrylate glue: A comparative clinical and histologic study. J Oral Maxillofac Surg 2013;71(2):241-8. [CrossRef]
  • 5. Öztürk H, Öztürk H, Duran H, Okur H. The Use of Glubran 2 in Management of Cleft Palate. Düzce Tıp Fakültesi Derg 2008;3:29-31.
  • 6. Turkaslan T, Ozcan H, Dayicioglu D, Ozsoy Z. Use of adhesives in cleft palate surgery:a new flap fixation technique. J Craniofac Surg 2005;4:719-22. [CrossRef]
  • 7. Kumar MS, Natta S, Shankar G, Reddy SHK, Visalakshi D, Seshiah G V. Comparison between Silk Sutures and Cyanoacrylate Adhesive in Human Mucosa- A Clinical and Histological Study. J Int oral Health 2013;5(5):95-100.
  • 8. Quinn JV, Osmond MH, Yurack JA, Moir PJ. N-2- butylcyanoacrylate: risk of bacterial contamination with an appraisal of its antimicrobial effects. J Emerg Med 1995;13(4):581-5. [CrossRef]
  • 9. Montanaro L, Arciola CR, Cenni E, Ciapetti G, Savioli F, Filippini F, et al. Cytotoxicity, blood compatibility and antimicrobial activity of two cyanoacrylate glues for surgical use. Biomaterials 2000;22(1):59-66. [CrossRef]
  • 10. Kull S, Martinelli I, Briganti E, Losi P, Spiller D, Tonlorenzi S, et al. Glubran®2 Surgical Glue: In Vitro Evaluation of Adhesive and Mechanical Properties. J Surg Res 2009;157(1):e15-21. [CrossRef]
  • 11. Wijdeveld MGMM, Maltha JC, Grupping EM, De Jonge J, Kuijpers-Jagtman AM. A histological study of tissue response to simulated cleft palate surgery at different ages in Beagle dogs. Arch Oral Biol 1991;36(11):837-43. [CrossRef]
  • 12. In de Braekt MMH, Alphen FAM V, Kuijpers-Jagtman AM, Maltha JC. Wound Healing and Wound Contraction After Palatal Surgery and Implantation of Poly-(L-Lactic) Acid Membranes in Beagle Dogs. J Oral Maxillofac Surg 1992;50:359-64. [CrossRef]
  • 13. Gökmen Z, MD. Effects of Hyaluronic Acid After the Cleft Palate Operation on the Growth of Maxilla in a Rat Model Cleft. Uludağ University, Department of Plastic Reconstructive and Aesthetic Surgery Aesthetic Surgery, Master Thesis. Uludağ University; 2012.
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm ARAŞTIRMA
Yazarlar

Furkan Karabulut Bu kişi benim 0000-0002-6668-3495

Serhat Özbek Bu kişi benim 0000-0001-5689-0979

Yayımlanma Tarihi 25 Nisan 2021
Gönderilme Tarihi 10 Mayıs 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 84 Sayı: 2

Kaynak Göster

APA Karabulut, F., & Özbek, S. (2021). IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL. Journal of Istanbul Faculty of Medicine, 84(2), 197-207. https://doi.org/10.26650/IUITFD.2020.0065
AMA Karabulut F, Özbek S. IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL. İst Tıp Fak Derg. Nisan 2021;84(2):197-207. doi:10.26650/IUITFD.2020.0065
Chicago Karabulut, Furkan, ve Serhat Özbek. “IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL”. Journal of Istanbul Faculty of Medicine 84, sy. 2 (Nisan 2021): 197-207. https://doi.org/10.26650/IUITFD.2020.0065.
EndNote Karabulut F, Özbek S (01 Nisan 2021) IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL. Journal of Istanbul Faculty of Medicine 84 2 197–207.
IEEE F. Karabulut ve S. Özbek, “IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL”, İst Tıp Fak Derg, c. 84, sy. 2, ss. 197–207, 2021, doi: 10.26650/IUITFD.2020.0065.
ISNAD Karabulut, Furkan - Özbek, Serhat. “IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL”. Journal of Istanbul Faculty of Medicine 84/2 (Nisan 2021), 197-207. https://doi.org/10.26650/IUITFD.2020.0065.
JAMA Karabulut F, Özbek S. IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL. İst Tıp Fak Derg. 2021;84:197–207.
MLA Karabulut, Furkan ve Serhat Özbek. “IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL”. Journal of Istanbul Faculty of Medicine, c. 84, sy. 2, 2021, ss. 197-0, doi:10.26650/IUITFD.2020.0065.
Vancouver Karabulut F, Özbek S. IN VIVO USE OF N-BUTYL-2-CYANOACRYLATE IN CLEFT PALATE SURGERY AND A COMPARISON OF ITS EFFICACY WITH SUTURE MATERIAL. İst Tıp Fak Derg. 2021;84(2):197-20.

Contact information and address

Addressi: İ.Ü. İstanbul Tıp Fakültesi Dekanlığı, Turgut Özal Cad. 34093 Çapa, Fatih, İstanbul, TÜRKİYE

Email: itfdergisi@istanbul.edu.tr

Phone: +90 212 414 21 61