BRUNEİ KADINLARINDA İNTRAUTERİN İNSEMİNASYON SONUÇLARINI ETKİLEYEN FAKTÖRLER

Yıl 2024, Cilt: 87 Sayı: 4, 334 - 339, 25.10.2024

Syazana Binti Suhaili , Rehana Rehman , Faiza Alam

https://doi.org/10.26650/IUITFD.1437923

Öz

Amaç: Bu çalışmanın amacı, intrauterin inseminasyon (IUI) uygulanan kadınlarda yaş, vücut kitle indeksi (BMI), hormonal profil, kısırlık süresi ve nedenlerinin gebelik sonuçları üzerine etkisinin araştırılmasıdır.
Gereç ve Yöntem: Bu retrospektif çalışmaya, 2015-2019 yılları arasında Brunei Sultanlığı Raja-Isteri-Pengiran-Anak-Saleha Has tanesi'nde IUI uygulanan 199 infertil kadın dahil edildi. Yaş, BMI, hormonal profil, kısırlık süresi ve nedenleri ile tedavinin hamilelik sonucu ile ilişkisi incelendi. IUI sonrası gebelik, idrar gebelik testi ile doğrulandı. Kategorik değişkenler için istatistiksel analiz test leri Ki-Kare testi ve Fisher testi kullanıldı. Sayısal değişkenler için tek yönlü ANOVA testi uygulandı. P-değerleri <0,05 ise istatistik sel olarak anlamlı kabul edildi.
Bulgular: Yaş ortalaması 32,8±4,9 ve ortalama BMI 24,7 kg/m2 olan çalışma grubunda gebe kalanlar arasında %12,5'i normal, %5,5'i fazla kilolu ve %9'u obez idi. Tüm grupta 18 kadında (%9) başarılı sonuçlar elde edildi. BMI ile gebelik sonucu arasında anlamlı bir ilişki olmamasına rağmen, pozitif sonucu olan kadın ların %83'ü obezdi. Ayrıca, altı yıldan düşük infertilite süresi olan kadınların %72,2'sinin gebe kaldığı görüldü. BMI arttıkça hor monal değerlerde azalma eğiliminin olduğu gözlendi (p<0,05). Hormonal değerlerin tümünün IUI sonucunun belirlenmesinde anlamlı olmadığı sonucuna varıldı (p>0,05).
Sonuç: İnfertilite nedeni açıklanamayan veya kadın kaynaklı ol gularda IUI sonrası başarılı sonuçların alındığı gözlendi. Erkek infertilite faktörünün gebelik sonucunu etkilemediği gösterildi. Yaşları 30-39 aralığında, kısırlık süresi altı yıldan az ve BMI indeksi >25 kg/m2 olan kadınlarda gebelik elde edilebilmiştir.

Anahtar Kelimeler

Kadın infertilitesi, klinik özellikler, intrauterin inseminasyon, gebelik sonucu

Proje Numarası

None

FACTORS INFLUENCING INTRAUTERINE INSEMINATION OUTCOMES IN BRUNEI FEMALES

Öz

Objective: To determine the effects of female age, body mass index (BMI), hormonal profile, infertility duration, and causes on pregnancy outcomes of females undergoing intrauterine insemination (IUI).
Material and Method: This retrospective study included 199 infertile females who underwent IUI from 2015 to 2019 at Raja-Is teri-Pengiran-Anak-Saleha Hospital, Brunei Darussalam. Age, BMI, hormonal profile, duration of infertility, and causes of infer tility associated with pregnancy outcome during treatment were studied. Urine pregnancy test confirmed the pregnancy post-IUI. The statistical analysis tests for categorical variables were the Chi-Square test and Fisher’s exact test. One-way ANOVA was used to assess numerical variables. P-values <0.05 were deemed statistically significant.
Result: The mean age of the pregnant females was 32.8±4.9 years, the mean BMI was 24.7 kg/m2 and 12.5% of the participants had normal weight, 5.5% were overweight, and 9% were obese. Overall, 18 females (9%) achieved successful outcomes. Despite the lack of a significant relationship between BMI and pregnancy outcome, 83% of females with positive outcomes were obese. Furthermore, 72.2% of the females who were infertile for <6 years had conceived. A decreasing trend of hormones was noticed with an increasing BMI (p<0.05). Overall hormonal values did not significantly determine IUI outcome (p>0.05).
Conclusion: Successful outcomes after IUI were observed in fe males with unexplained or female-caused infertility. Male infer tility did not influence the positive pregnancy outcome. Females with an age range of 30-39 years, duration of infertility less than six years, and BMI index of >25 kg/m2 were able to conceive.

Anahtar Kelimeler

Female infertility, clinical characteristics, intrauterine insemination, pregnancy outcome

Etik Beyan

The approval was obtained from PAPRSB Institute of Health Science Research Ethics Committee (IHSREC), Universiti Brunei Darussalam (UBD/PAPRSBIHSREC/2021/83)

Destekleyen Kurum

PAPRSB Institute of Health Science Research Ethics Committee (IHSREC), Universiti Brunei Darussalam

Proje Numarası

None

Teşekkür

Thank you

Kaynakça

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