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MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS

Yıl 2025, Cilt: 88 Sayı: 1, 80 - 82, 31.01.2025
https://doi.org/10.26650/IUITFD.1509646

Öz

There is limited information regarding the administration of live vaccines to paediatric transplant patients who are at increased risk of infection. A 7-year-old liver transplant patient who had everolimus therapy was evaluated for Measles-Mumps-Rubella (MMR) vaccination. After checking the lymphocyte count, immunoglobulin G, and serum everolimus levels, the MMR vaccine was administered. No side effects were observed during follow-up, and the antibody levels were found to be positive after two months. This article presents a case of paediatric solid organ transplantation patient who received a measles-mumps-rubella vaccination while receiving immunosuppressive everolimus therapy.

Kaynakça

  • Kamei K. Live attenuated vaccines in patients receiving immunosuppressive agents. Pediatr Nephrol 2023;38(12):3889-900. [CrossRef] google scholar
  • Coppeta L, Ferrari C, Somma G, Giovinazzo V, Buonomo E, Trabucco Aurilio M, et al. Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome. Vaccines 2023;11(7):1256. [CrossRef] google scholar
  • Feldman AG, Beaty BL, Curtis D, Juarez-Colunga E, Kempe A. Incidence of Hospitalization for Vaccine-Preventable Infections in Children Following Solid Organ Transplant and Associated Morbidity, Mortality, and Costs. JAMA Pediatr 2019;173(3):260-8. [CrossRef] google scholar
  • Liu Y, Sun LY, Zhu ZJ, Lin W, Qu W, Zeng ZG. Measles Virus Infection in Pediatric Liver Transplantation Recipients. Transplant Proc 2015;47(9):2715-8. [CrossRef] google scholar
  • Suresh S, Upton J, Green M, Pham-Huy A, Posfay-Barbe KM, Michaels MG, et al. Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018. Pediatr Transplant 2019;23(7):e13571. [CrossRef] google scholar
  • Manzia TM, Antonelli B, Carraro A, Conte G, Guglielmo N, Lauterio A, et al. Immunosuppression in adult liver transplant recipients: a 2024 update from the Italian Liver Transplant Working Group. Hepatol Int 2024;18(5):1416-30 [CrossRef] google scholar
  • Shipkova M, Hesselink DA, Holt DW, Billaud EM, van Gelder T, Kunicki PK, et al. Therapeutic Drug Monitoring of Everolimus: A Consensus Report. Therapeutic Drug Monitoring 2016;38(2):143. [CrossRef] google scholar
  • Witzke O, Sommerer C, Arns W. Everolimus immunosuppression in kidney transplantation: What is the optimal strategy? Transplant Rev (Orlando) 2016;30(1):3-12. [CrossRef] google scholar
  • Keskindemirci G, Önal Z, Özbörü Aşkan Ö, Yücel E, Varol S, Hançerli Törün S, et al. Attenuated live vaccine in children with solid organ transplantation on everolimus therapy: Report of two cases. Pediatr Transplant 2023;27(2):e14426. [CrossRef] google scholar
  • Shinjoh M, Hoshino K, Takahashi T, Nakayama T. Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation. Vaccine 2015;33(5):701-7. [CrossRef] google scholar
  • Kawano Y, Suzuki M, Kawada J ichi, Kimura H, Kamei H, Ohnishi Y, et al. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Vaccine 2015;33(12):1440-5. [CrossRef] google scholar
  • Hartley C, Thomas T, Smith SK, Karnsakul W. Live-Attenuated Vaccines in Pediatric Solid Organ Transplant. Vaccines 2024;12(4):376. [CrossRef] google scholar

EVEROLIMUS KULLANAN BİR PEDİATRİK TRANSPLANT OLGUSUNDA KIZAMIK-KABAKULAK-KIZAMIKÇIK AŞISI UYGULAMASI

Yıl 2025, Cilt: 88 Sayı: 1, 80 - 82, 31.01.2025
https://doi.org/10.26650/IUITFD.1509646

Öz

İnfeksiyon riskinin artmış olduğu pediatrik transplantasyon hastalarında canlı aşıların uygulanması ile ilgili bilgiler sınırlı dır. Yedi yaşında, halen evorolimus kullanmakta olan karaciğer nakli hastası Kızamık-Kabakulak-Kızamıkçık (KKK) aşısı yapılmak amacıyla değerlendirildi. Lenfosit sayısı, immünoglobulin G ve serum everolimus düzeyleri kontrol edildikten sonra KKK aşısı uygulandı. İzlemde yan etki saptanmayan olguda, iki ay sonra bakılan antikor düzeyleri pozitif bulundu. Bu yazıda immüno supresif everolimus tedavisi alırken Kızamık-Kabakulak-Kıza mıkçık aşısı uygulanan bir pediatrik solid organ nakli olgusu sunulmaktadır.

Kaynakça

  • Kamei K. Live attenuated vaccines in patients receiving immunosuppressive agents. Pediatr Nephrol 2023;38(12):3889-900. [CrossRef] google scholar
  • Coppeta L, Ferrari C, Somma G, Giovinazzo V, Buonomo E, Trabucco Aurilio M, et al. Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome. Vaccines 2023;11(7):1256. [CrossRef] google scholar
  • Feldman AG, Beaty BL, Curtis D, Juarez-Colunga E, Kempe A. Incidence of Hospitalization for Vaccine-Preventable Infections in Children Following Solid Organ Transplant and Associated Morbidity, Mortality, and Costs. JAMA Pediatr 2019;173(3):260-8. [CrossRef] google scholar
  • Liu Y, Sun LY, Zhu ZJ, Lin W, Qu W, Zeng ZG. Measles Virus Infection in Pediatric Liver Transplantation Recipients. Transplant Proc 2015;47(9):2715-8. [CrossRef] google scholar
  • Suresh S, Upton J, Green M, Pham-Huy A, Posfay-Barbe KM, Michaels MG, et al. Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018. Pediatr Transplant 2019;23(7):e13571. [CrossRef] google scholar
  • Manzia TM, Antonelli B, Carraro A, Conte G, Guglielmo N, Lauterio A, et al. Immunosuppression in adult liver transplant recipients: a 2024 update from the Italian Liver Transplant Working Group. Hepatol Int 2024;18(5):1416-30 [CrossRef] google scholar
  • Shipkova M, Hesselink DA, Holt DW, Billaud EM, van Gelder T, Kunicki PK, et al. Therapeutic Drug Monitoring of Everolimus: A Consensus Report. Therapeutic Drug Monitoring 2016;38(2):143. [CrossRef] google scholar
  • Witzke O, Sommerer C, Arns W. Everolimus immunosuppression in kidney transplantation: What is the optimal strategy? Transplant Rev (Orlando) 2016;30(1):3-12. [CrossRef] google scholar
  • Keskindemirci G, Önal Z, Özbörü Aşkan Ö, Yücel E, Varol S, Hançerli Törün S, et al. Attenuated live vaccine in children with solid organ transplantation on everolimus therapy: Report of two cases. Pediatr Transplant 2023;27(2):e14426. [CrossRef] google scholar
  • Shinjoh M, Hoshino K, Takahashi T, Nakayama T. Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation. Vaccine 2015;33(5):701-7. [CrossRef] google scholar
  • Kawano Y, Suzuki M, Kawada J ichi, Kimura H, Kamei H, Ohnishi Y, et al. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Vaccine 2015;33(12):1440-5. [CrossRef] google scholar
  • Hartley C, Thomas T, Smith SK, Karnsakul W. Live-Attenuated Vaccines in Pediatric Solid Organ Transplant. Vaccines 2024;12(4):376. [CrossRef] google scholar
Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Olgu Sunumu
Yazarlar

Aybüke Kaçır 0009-0002-3474-5863

Övgü Büke 0000-0002-3922-2976

Nalan Karabayır 0000-0002-8003-1952

Mine Başıbüyük 0000-0002-9159-4961

Demet Deniz Bilgin 0000-0002-9794-9460

Özlem Öcal 0000-0002-4210-2430

Yayımlanma Tarihi 31 Ocak 2025
Gönderilme Tarihi 3 Temmuz 2024
Kabul Tarihi 7 Kasım 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 88 Sayı: 1

Kaynak Göster

APA Kaçır, A., Büke, Ö., Karabayır, N., Başıbüyük, M., vd. (2025). MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS. Journal of Istanbul Faculty of Medicine, 88(1), 80-82. https://doi.org/10.26650/IUITFD.1509646
AMA Kaçır A, Büke Ö, Karabayır N, Başıbüyük M, Bilgin DD, Öcal Ö. MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS. İst Tıp Fak Derg. Ocak 2025;88(1):80-82. doi:10.26650/IUITFD.1509646
Chicago Kaçır, Aybüke, Övgü Büke, Nalan Karabayır, Mine Başıbüyük, Demet Deniz Bilgin, ve Özlem Öcal. “MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS”. Journal of Istanbul Faculty of Medicine 88, sy. 1 (Ocak 2025): 80-82. https://doi.org/10.26650/IUITFD.1509646.
EndNote Kaçır A, Büke Ö, Karabayır N, Başıbüyük M, Bilgin DD, Öcal Ö (01 Ocak 2025) MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS. Journal of Istanbul Faculty of Medicine 88 1 80–82.
IEEE A. Kaçır, Ö. Büke, N. Karabayır, M. Başıbüyük, D. D. Bilgin, ve Ö. Öcal, “MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS”, İst Tıp Fak Derg, c. 88, sy. 1, ss. 80–82, 2025, doi: 10.26650/IUITFD.1509646.
ISNAD Kaçır, Aybüke vd. “MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS”. Journal of Istanbul Faculty of Medicine 88/1 (Ocak 2025), 80-82. https://doi.org/10.26650/IUITFD.1509646.
JAMA Kaçır A, Büke Ö, Karabayır N, Başıbüyük M, Bilgin DD, Öcal Ö. MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS. İst Tıp Fak Derg. 2025;88:80–82.
MLA Kaçır, Aybüke vd. “MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS”. Journal of Istanbul Faculty of Medicine, c. 88, sy. 1, 2025, ss. 80-82, doi:10.26650/IUITFD.1509646.
Vancouver Kaçır A, Büke Ö, Karabayır N, Başıbüyük M, Bilgin DD, Öcal Ö. MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS. İst Tıp Fak Derg. 2025;88(1):80-2.

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