FENİLKETONÜRİLİ BİREYLERDE UZUN SÜRELİ TAKİPTE BÜYÜMENİN DEĞERLENDİRİLMESİ

Yıl 2025, Cilt: 88 Sayı: 1, 38 - 44, 31.01.2025

Mehmet Cihan Balcı , Ayşe Gül Güven , Meryem Karaca , Gülden Fatma Gökçay

https://doi.org/10.26650/IUITFD.1552678

Öz

Amaç: Çalışmamızın amacı özel beslenme tedavisi alan Fenil ketonüri (PKU) hastalarının antropometrik indekslerini ve bu in dekslerin zaman içerisinde nasıl değiştiğini incelemek, hayatın erken yıllarındaki antropometrik ölçümleri hayatın ilerleyen dö nemlerinde aşırı tartılılık/obezite gelişimi öngörüsü açısından değerlendirmekti.
Gereç ve Yöntem: Tek merkezli, uzun dönemli, gözlemsel ve ta nımlayıcı çalışmaya, yaşamın ilk iki ayında tanı alarak beslenme tedavisine başlanmış 102 fenilketonürili birey dâhil edilmiştir.
Bulgular: Hasta grubumuzda yapılan her iki değerlendirmede de aşırı tartılılık ve obezite oranları genel topluma kıyasla düşük bulunmuştur. Hastaların boya göre tartı (p=0.000), yaşa göre tartı (p=0.000), yaşa göre boy (p=0.000) ve beden kitle indekslerinde (p=0.052) izlem sürecinin başındaki değerlendirmeye kıyasla azalma tespit edilmiştir. Kırk altı hastanın antropometrik değerlendirmelerinde değişiklik gözlenmiştir.
Sonuç: Özel beslenme tedavileri alan tüm hasta gruplarında ant ropometrik ölçümlerin ve vücut kompozisyonu değişikliklerinin izlemi tedavi etkinliğinin belirlenmesi ve izleminde kritik öneme sahiptir. Hasta grubumuzda obezite ve aşırı tartılılık oranlarının sağlıklı topluma kıyasla düşük olmasının nedeninin izlemde has taların beslenme tedavilerinin ve antropometrik parametreleri nin yakından izlenmesi olduğu düşünülmüştür.

Anahtar Kelimeler

Fenilketonüri, beslenme tedavisi, vücut küt le indeksi, obezite, aşırı tartı

EVALUATION OF GROWTH IN LONG-TERM FOLLOW-UP IN INDIVIDUALS WITH PHENYLKETONURIA

Öz

Objective: The aim of our study was to evaluate the anthropo metric parameters of patients with Phenylketonuria (PKU) re ceiving special nutritional therapy and how these parameters changed over time, and to evaluate anthropometric measure ments in the early years of life in terms of predicting the devel opment of overweight/obesity later in life.
Material and Methods: In this single-centre, long-term, obser vational, and descriptive study, 102 individuals with phenylke tonuria who were diagnosed in the first two months of life and initiated nutritional treatment were included.
Results: The ratios of overweight and obesity were found to be lower in our patient group compared with the general population in both evaluations. The weight-for-age (p=0.000), heightfor-age (p=0.000), weight-for-height (p=0.000), and body mass index (p=0.052) of the patients decreased compared with the evaluation at the baseline of the follow-up period. Forty-six patients had a change in their anthropometric evaluations.
Conclusion: Monitoring anthropometric measurements and body composition changes in all patient groups receiving specialised nutritional therapies is critical in determining and monitoring treatment efficacy. The reason for the low ratios of obesity and overweight in our patient group compared with the healthy population is thought to be the close monitoring of nutritional therapies and anthropometric parameters of the patients in the follow-up.

Anahtar Kelimeler

Phenylketonuria, nutrition therapy, body mass index, obesity, overweight

Etik Beyan

The study was approved by the Ethics Committee of Istanbul Medical Faculty (file number: 2023/1636). This study has been carried out in accordance with the ethical standards of the responsible institutional committee on human experimentation and with the Helsinki Declaration. Informed consent was obtained from patients or their legal guardians after the procedure had been fully explained.

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