PRETERMDE GERMİNAL MATRİKS İNTRAVENTRİKÜLER KANAMA

Yıl 2011, Cilt: 74 Sayı: 2, 43 - 46, 10.11.2011

İpek Akman Nilüfer Galip

Öz

Prematüre bebeklerde görülebilen nörogelişimsel sorunların önemli nedenlerinden biri intraventriküler
kanamalardır (İVK). İVK patogenezinde çevresel ve genetik faktörlerin rolü üzerinde çalışmalar devam
etmekte ve önleme stratejileri geliştirilmeye çalışılmaktadır. Bu derleme yazısında İVK nedenleri, klinik
seyir, komplikasyonları ve İVK önleme stratejileri tartışılmıştır.

Anahtar Kelimeler

Prematüre, germinal matriks kanamaları, etyoloji

Kaynakça

• Adams-Chapman I, Hansen NI, Stoll BJ,Higgins R, Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics 2008;121: 1167
• Bassan H. Intracranial hemorrhage in the preterm infant: Understanding it preventing it Clin Perinatal 2009; 36: 762.
• Brion LP, Bell EF, Raghuveer TS .Vitamin E supplemantation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev ;CD003665.
• Harding DR, Humphries SE, Whitelaw A , Marlow N, Montgomery HE. Cognitive outcome and cyclooxygehase – 2 gene (-765 G/C) variation in the preterm infant. Arch Dis Child Fetal Neonatal Ed 2007; :1008-1012.
• Kuban KC, Allred EN, O Shea IM, Paneth N, Pagano M, Dammann O, Leviton A, Du Plessis A, Westra SJ, Miller CR, Bassan H, Krishnamoorthy K, Junewick J, Olumu N, Romano E, Seibert J, Engelke S, Karna P, Batton D, O'Connor SE, Keller CE; ELGAN Study investigators.Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children born at extremely low gestational age. J Child Neurol 2009; :63-72.
• Ohlsson A, Roberts RS, Schmidt B , Davis P, Moddeman D, Saigal S, Solimano A, Vincer M, Wright L. Male/Famale differences in indomethacin effects in preterm infants. J Pediatr 2005;147:860-862
• Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Alexander JM, Harper M, Thorp JM Jr, Ramin SM, Malone FD, Carpenter M, Miodovnik M, Moawad A, O'Sullivan MJ, Peaceman AM, Hankins GD, Langer O, Caritis SN, Roberts JM. A randomized controlled trial of magnesium sulfate for the prevention of cerebrel palsy. N Engl J Med 2008;359:895- 905.
• Tam EW, Feriero DM, Xu D, Berman JI, Vigneron DB, Barkovich AJ, Miller SP. Cerebellar development in the preterm neonate effect of supratentorial brain injury. Pediatr Res 2009,66: 102-106.
• Tarcan A, Olalı A, Tekşam M, Gürakan B. Çok düşük doğum ağırlıklı prematüre bebeklerde periventriküler- intraventriküler kanama ve periventriküler lökomalasi risk etkenlerinin incelenmesi, Türk Pediatri Arşivi ; 40: 28- 32. Vasileiadis GT, Gelman N. Han VK, Williamn LA, Mann R, Bureau Y, Thompson RT Uncomplicated intraventricular hemorrhage is followed by reduced cortical volume at near-term age. Pediatrics 2004; 114: 372.
• Veldman A, Josef J, Fischer D, Volk WR. A prospective pilot study of prophylactic treatment of preterm neonates with recombinant activated factor VII during the first 72 hours of life, Pediatr Crit Care Med ;7:34-39. Volpe J. Intracranial hemorrhage: Neurology of the newborn. 5th edition. Philadelphia W.B Saunders Co ; 481-588. İstanbul Tıp Fakültesi Dergisi Cilt / Volume: 74 • Sayı / Number: 2 • Yıl/Year: 2011