NONALKOLİK KARACİĞER YAĞLANMASI VE STEATOHEPATİT

Yıl 2010, Cilt: 73 Sayı: 3, 85 - 91, 10.11.2011

Yaşar Çolak İlyas Tuncer

Öz

Nonalkolik karaciğer yağlanması (NAFLD), artık dünyada en yaygın karaciğer hastalığı olarak kabul edilmektedir. Bu, basit steatozdan steatohepatite, son dönem karaciğer hastalığına (siroz) ve hepatoselüler karsinoma kadar gidebilen farklı derecedeki durumlar için kullanılan genel bir isimdir. Bu durum sıklıkla metabolik sendromun özelliklerini gösterir ve insülin rezistansı ile ilişkilidir. Hastalık asemptomatik karaciğer enzim yüksekliğinden siroza ve karaciğer yetersizliğinin komplikasyonlarına kadar değişik şekillerde görünmektedir. Bu derlemede NAFLD etiyolojisi, patogenezi, tanısı ve tedavi yaklaşımları tartışılmıştır.

Anahtar Kelimeler

Nonalkolik karaciğer yağlanması (NAFLD), nonalkolik steatohepatit (NASH), insülin rezistansı, inflamasyon

Kaynakça

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