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NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ

Yıl 2006, Cilt: 69 Sayı: 1, 10 - 14, 15.11.2011

Öz

Amaç: Bu retrospektiv çalışmanın amacı, nonmetastatik nazofarengeal karsinomlu 100 hastanın survi ve rekürrens paternini analiz etmekti. Gereç ve yöntem: 1991-2003 yılları arasında tedavi edilen 100 nazofarengeal karsinomlu hasta retrospektif olarak incelendi. 24’ü yalnız radyoterapi ile tedavi edilirken, 76’sına kombine model tedavi (cisplatin bazlı 2-4 kür neoadjuvant kemoterapi ve radyoterapi) uygulanmıştı. Nazofarengeal bölgeye 66-70 Gy, lenf nodlarına 50 Gy, servikal hastalık mevcut ise tutulan alana 15-20 Gy boost dozu verilmişti. Bulgular: AJCC 1997 evreleme sistemine göre, hastaların 20’si evre II, 47’si evre III, 33’ü evre IV’tü. Tüm hastalar skuamoz hücreli nazofarengial karsinom tanısı almıştı (18 WHO I-II, 82 WHO III). Minimum takip süresi 2 yıldı. İndüksiyon kemoterapisine yanıt oranı %75 (%13,2 tam ve %61,8 kısmi), yanıtsız olanların oranı (progresif hastalık) %7,9 ve stabil hastalık oranı %17,1’di. Radyoterapi sonrası başarısızlık oranı %53’tü. Bunların %56,6’sı lokoregional nüks, %28,3’ü lokoregional nüks ve uzak metastaz ve %15,1’i izole metastazdı. 5 yıllık genel sağ kalım yalnız radyoterapi verilenlerde %57,1, kombine tedavi verilenlerde %57,7 idi. Sonuç: İndüksiyon kemoterapisi nazofarengeal karsinomlu hastalarda tedavi sonuçlarını ve başarısızlık paternini değiştirmemiştir.

Kaynakça

  • Al-Sarraf M, Reddy MS. Nasopharyngeal carcinoma. Curr Tre- at Options Oncol 2002; 3:21-32.
  • Chan AT, Teo PM, Leung TW, Leung SF, Lee WY, Yeo W, Choi PH, Johnson PJ. A prospective randomized study of chemothe- rapy adjunctive to definitive radiotherapy in advanced nasop- haryngeal carcinoma. Int J Radiat Oncol Biol Phys 1995; 33:569-577.
  • Cheng SH, Yen KL, Jian JJ, Tsai SY, Chu NM, Leu SY, Chan KY, Tan TD, Cheng JC, Hsieh CY, Huang AT. Examining prog- nostic factors and patterns of failure in nasopharyngeal carcino- ma following concomitant radiotherapy and chemotherapy: im- pact on future clinical trials. Int J Radiat Oncol Biol Phys 2001; 50:717-726.
  • Cheng SH, Jian JJ, Tsai SY, Yen KL, Chu NM, Chan KY, Tan TD, Cheng JC, Leu SY, Hsieh CY, Huang AT. Long-term sur- vival of nasopharyngeal carcinoma following concomitant radi- otherapy and chemotherapy. Int J Radiat Oncol Biol Phys 2000; 48:1323-1330.
  • Chua DT, Ma J, Sham JS, Mai HQ, Choy DT, Hong MH, Lu TX, Min HQ. Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials. J Clin Oncol 2005; 23:1118-1124.
  • Chua DT, Sham JS, Wei WI, Ho WK, Au G, Choy D. Control of regional metastasis after induction chemotherapy and radiothe- rapy for nasopharyngeal carcinoma. Head Neck 2002; 24:350- 360.
  • Chua DT, Sham JS, Choy D, Lorvidhaya V, Sumitsawan Y, Thongprasert S, Wootiprux V, Cheirsilpa A, Azhar T, Reksodi- putro AH. Preliminary report of the Asian-Oceanian Clinical On- cology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasop- haryngeal carcinoma. Asian-Oceanian Clinical Oncology Asso- ciation Nasopharynx Cancer Study Group. Cancer 1998; 83:2270-2283.
  • Chua DT, Sham JS, Choy D, Kwong DL, Au GK, Kwong PW, Yau CC, Cheng AC, Wan KY. Patterns of failure after induction chemotherapy and radiotherapy for locoregionally advanced na- sopharyngeal carcinoma: the Queen Mary Hospital experience. Int J Radiat Oncol Biol Phys 2001; 49:1219-1228.
  • Daniilidis J, Constantinidis J, Fountzilas G. Combined radioche- motherapy in locally advanced nasopharyngeal carcinoma HNO 2001; 49:732-738.
  • Farias TP, Dias FL, Lima RA, Kligerman J, de Sa GM, Barbosa MM, Goncalves FB Jr. Prognostic factors and outcome for na- sopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 2003; 129:794-799.
  • Fonseca E, Cruz JJ, Rodriguez CA, Gomez-Bernal A, Martin A, Sanchez P, Nieto A, Soria P, Vega MJ, Munoz A, Pardal JL. Ne- oadjuvant chemotherapy with continuous infusion of cisplatin and 5-fluorouracil, with or without leucovorin, for locally advan- ced nasopharyngeal carcinoma. J Infus Chemother 1996; 6:217- 220
  • Geara FB, Glisson BS, Sanguineti G, Tucker SL, Garden AS, Ang KK, Lippman SM, Clayman GL, Goepfert H, Peters LJ. In- duction chemotherapy followed by radiotherapy versus radiot- herapy alone in patients with advanced nasopharyngeal carcino- ma: results of a matched cohort study. Cancer 1997; 79:1279- 1286.
  • Gruner A, Grabenbauer GG, Rodel C, Weidenbecher M, Martus P, Iro H, Sauer R. Nasopharyngeal carcinoma: only irradiation or simultaneous radiochemotherapy? Strahlenther Onkol 1999; 175:591-596.
  • Hareyama M, Sakata K, Shirato H, Nishioka T, Nishio M, Su- zuki K, Saitoh A, Oouchi A, Fukuda S, Himi T. A prospective, randomized trial comparing neoadjuvant chemotherapy with ra- diotherapy alone in patients with advanced nasopharyngeal car- cinoma.Cancer 2002; 94:2217-2223.
  • Hong S, Wu HG, Chie EK, Bang YJ, Heo DS, Kim KH, Sung MW, Park CI. Neoadjuvant chemotherapy and radiation therapy compared with radiation therapy alone in advanced nasopharyn- geal carcinoma. Int J Radiat Oncol Biol Phys 1999; 45:901-905.
  • Huncharek M, Kupelnick B. Combined chemoradiation versus radiation therapy alone in locally advanced nasopharyngeal car- cinoma: results of a meta-analysis of 1,528 patients from six ran- domized trials. Am J Clin Oncol 2002; 25:219-223.
  • Langendijk JA, Leemans CR, Buter J, Berkhof J, Slotman BJ. The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature. J Clin Oncol 2004; 22:4604-4612.
  • Ma BB, Chan AT. Recent perspectives in the role of chemothe- rapy in the management of advanced nasopharyngeal carcino- ma. Cancer 2005; 103:22-31.
  • Ma J, Mai HQ, Hong MH, Min HQ Mao ZD, Cui NJ, Lu TX, Mo HY. Results of a prospective randomized trial comparing ne- oadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol 2001; 19:1350-1357
  • Ozyar E, Gurkaynak M, Yildiz F, Atahan IL. Non-metastatic sta- ge IV nasopharyngeal carcinoma patients: analysis of the pattern of relapse and survival. Radiother Oncol 2004; 72:71-77.
  • Rischin D, Corry J, Smith J, Stewart J, Hughes P, Peters L. Ex- cellent disease control and survival in patients with advanced na- sopharyngeal cancer treated with chemoradiation. J Clin Oncol 2002; 20:1845-1852.
  • Teo PM, Chan AT, Lee WY, Leung TW, Johnson PJ. Enhance- ment of local control in locally advanced node-positive nasop- haryngeal carcinoma by adjunctive chemotherapy. Int J Radiat Oncol Biol Phys 1999; 43:261-271.
Yıl 2006, Cilt: 69 Sayı: 1, 10 - 14, 15.11.2011

Öz

Kaynakça

  • Al-Sarraf M, Reddy MS. Nasopharyngeal carcinoma. Curr Tre- at Options Oncol 2002; 3:21-32.
  • Chan AT, Teo PM, Leung TW, Leung SF, Lee WY, Yeo W, Choi PH, Johnson PJ. A prospective randomized study of chemothe- rapy adjunctive to definitive radiotherapy in advanced nasop- haryngeal carcinoma. Int J Radiat Oncol Biol Phys 1995; 33:569-577.
  • Cheng SH, Yen KL, Jian JJ, Tsai SY, Chu NM, Leu SY, Chan KY, Tan TD, Cheng JC, Hsieh CY, Huang AT. Examining prog- nostic factors and patterns of failure in nasopharyngeal carcino- ma following concomitant radiotherapy and chemotherapy: im- pact on future clinical trials. Int J Radiat Oncol Biol Phys 2001; 50:717-726.
  • Cheng SH, Jian JJ, Tsai SY, Yen KL, Chu NM, Chan KY, Tan TD, Cheng JC, Leu SY, Hsieh CY, Huang AT. Long-term sur- vival of nasopharyngeal carcinoma following concomitant radi- otherapy and chemotherapy. Int J Radiat Oncol Biol Phys 2000; 48:1323-1330.
  • Chua DT, Ma J, Sham JS, Mai HQ, Choy DT, Hong MH, Lu TX, Min HQ. Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials. J Clin Oncol 2005; 23:1118-1124.
  • Chua DT, Sham JS, Wei WI, Ho WK, Au G, Choy D. Control of regional metastasis after induction chemotherapy and radiothe- rapy for nasopharyngeal carcinoma. Head Neck 2002; 24:350- 360.
  • Chua DT, Sham JS, Choy D, Lorvidhaya V, Sumitsawan Y, Thongprasert S, Wootiprux V, Cheirsilpa A, Azhar T, Reksodi- putro AH. Preliminary report of the Asian-Oceanian Clinical On- cology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasop- haryngeal carcinoma. Asian-Oceanian Clinical Oncology Asso- ciation Nasopharynx Cancer Study Group. Cancer 1998; 83:2270-2283.
  • Chua DT, Sham JS, Choy D, Kwong DL, Au GK, Kwong PW, Yau CC, Cheng AC, Wan KY. Patterns of failure after induction chemotherapy and radiotherapy for locoregionally advanced na- sopharyngeal carcinoma: the Queen Mary Hospital experience. Int J Radiat Oncol Biol Phys 2001; 49:1219-1228.
  • Daniilidis J, Constantinidis J, Fountzilas G. Combined radioche- motherapy in locally advanced nasopharyngeal carcinoma HNO 2001; 49:732-738.
  • Farias TP, Dias FL, Lima RA, Kligerman J, de Sa GM, Barbosa MM, Goncalves FB Jr. Prognostic factors and outcome for na- sopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 2003; 129:794-799.
  • Fonseca E, Cruz JJ, Rodriguez CA, Gomez-Bernal A, Martin A, Sanchez P, Nieto A, Soria P, Vega MJ, Munoz A, Pardal JL. Ne- oadjuvant chemotherapy with continuous infusion of cisplatin and 5-fluorouracil, with or without leucovorin, for locally advan- ced nasopharyngeal carcinoma. J Infus Chemother 1996; 6:217- 220
  • Geara FB, Glisson BS, Sanguineti G, Tucker SL, Garden AS, Ang KK, Lippman SM, Clayman GL, Goepfert H, Peters LJ. In- duction chemotherapy followed by radiotherapy versus radiot- herapy alone in patients with advanced nasopharyngeal carcino- ma: results of a matched cohort study. Cancer 1997; 79:1279- 1286.
  • Gruner A, Grabenbauer GG, Rodel C, Weidenbecher M, Martus P, Iro H, Sauer R. Nasopharyngeal carcinoma: only irradiation or simultaneous radiochemotherapy? Strahlenther Onkol 1999; 175:591-596.
  • Hareyama M, Sakata K, Shirato H, Nishioka T, Nishio M, Su- zuki K, Saitoh A, Oouchi A, Fukuda S, Himi T. A prospective, randomized trial comparing neoadjuvant chemotherapy with ra- diotherapy alone in patients with advanced nasopharyngeal car- cinoma.Cancer 2002; 94:2217-2223.
  • Hong S, Wu HG, Chie EK, Bang YJ, Heo DS, Kim KH, Sung MW, Park CI. Neoadjuvant chemotherapy and radiation therapy compared with radiation therapy alone in advanced nasopharyn- geal carcinoma. Int J Radiat Oncol Biol Phys 1999; 45:901-905.
  • Huncharek M, Kupelnick B. Combined chemoradiation versus radiation therapy alone in locally advanced nasopharyngeal car- cinoma: results of a meta-analysis of 1,528 patients from six ran- domized trials. Am J Clin Oncol 2002; 25:219-223.
  • Langendijk JA, Leemans CR, Buter J, Berkhof J, Slotman BJ. The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature. J Clin Oncol 2004; 22:4604-4612.
  • Ma BB, Chan AT. Recent perspectives in the role of chemothe- rapy in the management of advanced nasopharyngeal carcino- ma. Cancer 2005; 103:22-31.
  • Ma J, Mai HQ, Hong MH, Min HQ Mao ZD, Cui NJ, Lu TX, Mo HY. Results of a prospective randomized trial comparing ne- oadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol 2001; 19:1350-1357
  • Ozyar E, Gurkaynak M, Yildiz F, Atahan IL. Non-metastatic sta- ge IV nasopharyngeal carcinoma patients: analysis of the pattern of relapse and survival. Radiother Oncol 2004; 72:71-77.
  • Rischin D, Corry J, Smith J, Stewart J, Hughes P, Peters L. Ex- cellent disease control and survival in patients with advanced na- sopharyngeal cancer treated with chemoradiation. J Clin Oncol 2002; 20:1845-1852.
  • Teo PM, Chan AT, Lee WY, Leung TW, Johnson PJ. Enhance- ment of local control in locally advanced node-positive nasop- haryngeal carcinoma by adjunctive chemotherapy. Int J Radiat Oncol Biol Phys 1999; 43:261-271.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Klinik Araştırma
Yazarlar

Öznur Aksakal Bu kişi benim

Orhan Kızılkaya Bu kişi benim

Oktay İncekara Bu kişi benim

Doğan Özcan Bu kişi benim

At All. Bu kişi benim

Yayımlanma Tarihi 15 Kasım 2011
Gönderilme Tarihi 15 Kasım 2011
Yayımlandığı Sayı Yıl 2006 Cilt: 69 Sayı: 1

Kaynak Göster

APA Aksakal, Ö., Kızılkaya, O., İncekara, O., Özcan, D., vd. (2011). NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ. Journal of Istanbul Faculty of Medicine, 69(1), 10-14.
AMA Aksakal Ö, Kızılkaya O, İncekara O, Özcan D, All. A. NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ. İst Tıp Fak Derg. Kasım 2011;69(1):10-14.
Chicago Aksakal, Öznur, Orhan Kızılkaya, Oktay İncekara, Doğan Özcan, ve At All. “NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ”. Journal of Istanbul Faculty of Medicine 69, sy. 1 (Kasım 2011): 10-14.
EndNote Aksakal Ö, Kızılkaya O, İncekara O, Özcan D, All. A (01 Kasım 2011) NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ. Journal of Istanbul Faculty of Medicine 69 1 10–14.
IEEE Ö. Aksakal, O. Kızılkaya, O. İncekara, D. Özcan, ve A. All., “NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ”, İst Tıp Fak Derg, c. 69, sy. 1, ss. 10–14, 2011.
ISNAD Aksakal, Öznur vd. “NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ”. Journal of Istanbul Faculty of Medicine 69/1 (Kasım 2011), 10-14.
JAMA Aksakal Ö, Kızılkaya O, İncekara O, Özcan D, All. A. NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ. İst Tıp Fak Derg. 2011;69:10–14.
MLA Aksakal, Öznur vd. “NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ”. Journal of Istanbul Faculty of Medicine, c. 69, sy. 1, 2011, ss. 10-14.
Vancouver Aksakal Ö, Kızılkaya O, İncekara O, Özcan D, All. A. NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ. İst Tıp Fak Derg. 2011;69(1):10-4.

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