Araştırma Makalesi
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The role of perivascular adipose tissue on human saphenous vein vascular tone

Yıl 2016, Cilt: 46 Sayı: 1, 1 - 13, 24.08.2016

Öz

Perivascular adipose tissue (PVAT) is situated outside of almost every blood vessel. Recent studies showed that PVAT provides mechanical support for blood vessels and secretes vasoactive adipokines that could regulate vascular tone. However, most of the studies evaluating PVAT effects on vascular tone have been performed with vessels derived from animals. Therefore, we aimed to investigate the role of PVAT surrounding human coronary bypass graft vessels such as saphenous vein (SV). Human SV preparations were set up in an organ bath in the presence or absence of their PVAT. The presence of PVAT significantly attenuated the contractile response to prostaglandin F2α (PGF2α). However, potassium chloride (KCI)-induced concentration-response curve wasn’t modified in PVAT-intact SV preparations. On the other hand, endothelium-dependent relaxation induced by acetylcholine (ACh) or endothelium-independent relaxation induced by sodium nitroprusside (SNP) were similar between SV with PVAT versus SV without PVAT preparations. Sensitivity of the SV to contractile agonists (KCI, PGF2α) or relaxant agonists (SNP, ACh) were not modified in the presence of PVAT. These results suggest that PVAT could decrease PGF2α-induced contractile tone via endothelium-independent mechanisms in SV. Retaining PVAT in SV preparations during bypass graft surgery could prevent graft vasospasm possibly via PVAT derived relaxant factor(s).

Kaynakça

  • Bunker AK, Laughlin MH (2010) Influence of exercise and perivascular adipose tissue on coronary artery vasomotor function in a familial hypercholesterolemic porcine atherosclerosis model, J. Appl. Physiol., 108: 490-497.
  • Dashwood MR, Tsui JC (2013) No-touch’saphenous vein harvesting improves graft performance in patients undergoing coronary artery bypass surgery: A journey from bedside to bench, Vas. Pharmacol., 58: 240-250.
  • Galvez B, de Castro J, Herold D, Dubrovska G, Arribas S, Gonzalez MC, Aranguez I, Luft FC, Ramos MP, Gollasch M, Fernandez Alfonso MS (2006) Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats, Arterioscler. Thromb. Vasc. Biol., 26: 1297-1302.
  • Gao YJ, Zeng ZH, Teoh K, Sharma AM, Abouzahr L, Cybulsky I, Lamy A, Semelhago L, Lee RM (2005) Perivascular adipose tissue modulates vascular function in the human internal thoracic artery, J. Thorac. Cardiovasc. Surg., 130: 1130-1136.
  • Gao YJ, Lu C, Su LY, Sharma AM, Lee RM (2007) Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide, Br. J. Pharmacol., 151: 323-31.
  • Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM (2002) Periadventitial fat releases a vascular relaxing factor, FASEB J., 16: 1057-1063.
  • Lu C, Zhao AX, Gao YJ, Lee RM (2011) Modulation of vein function by perivascular adipose tissue, Eur. J. Pharmacol., 657: 111-116.
  • Malinowski M, Deja MA, Golba KS, Roleder T, Biernat J, Wos S (2008) Perivascular tissue of internal thoracic artery releases potent nitric oxide and prostacyclin-independent anticontractile factor, Eur. J. Cardiothorac. Surg., 33: 225-231.
  • Oriowo MA (2015) Perivascular adipose tissue, vascular reactivity and hypertension, Med. Princ. Pract., 24: 29-37.
  • Ozen G, Topal G, Gomez I, Ghorreshi A, Boukais K, Benyahia C, Kanyinda L, Longrois D, Teskin O, Uydes-Dogan BS, Norel X (2013) Control of human vascular tone by prostanoids derived from perivascular adipose tissue, Prostaglandins. Other. Lipid. Mediat.,107:13-17.
  • Ozen G, Daci A, Norel X, Topal G (2015) Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling, Eur. J. Pharmacol., 766: 16-24.
  • Pearl JM, Manning PB, McNamara JL, Saucier MM, Thomas DW (1999) Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass, Ann. Thorac. Surg., 68: 1369-1375.
  • Sen O, Gonca S, Solakoglu S, Dalcik H, Dalcik C, Ozkara A (2013) Comparison of conventional and no-touch techniques in harvesting saphenous vein for coronary artery bypass grafting in view of endothelial damage, Heart. Surg. Forum., 16: 177-183.
  • Sepehripour AH, Jarral OA, Shipolini AR, McCormack DJ (2011) Does a ‘no-touch’ technique result in better vein patency, Interact. Cardiovasc. Thorac. Surg., 13: 626-630.
  • Soltis EE, Cassis LA (1991) Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness, Clin. Exp. Hypertens. A., 13: 277-296.
  • Souza DS, Bomfim V, Skoglund H, Dashwood MR, Borowiec JW, Bodin L, Filbey D (2001) High early patency of saphenous vein graft for coronary artery bypass harvested with surrounding tissue, Ann. Thorac. Surg., 71: 797-800.
  • Szasz T, Bomfim GF, Webb RC (2013) The influence of perivascular adipose tissue on vascular homeostasis, Vasc. Health. Risk. Manag., 9: 105-116.
  • Takemori K, Gao YJ, Ding L, Lu C, Su LY, An WS, Vinson C, Lee RM (2007) Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function, Hypertension., 49: 365-372.
Yıl 2016, Cilt: 46 Sayı: 1, 1 - 13, 24.08.2016

Öz

Kaynakça

  • Bunker AK, Laughlin MH (2010) Influence of exercise and perivascular adipose tissue on coronary artery vasomotor function in a familial hypercholesterolemic porcine atherosclerosis model, J. Appl. Physiol., 108: 490-497.
  • Dashwood MR, Tsui JC (2013) No-touch’saphenous vein harvesting improves graft performance in patients undergoing coronary artery bypass surgery: A journey from bedside to bench, Vas. Pharmacol., 58: 240-250.
  • Galvez B, de Castro J, Herold D, Dubrovska G, Arribas S, Gonzalez MC, Aranguez I, Luft FC, Ramos MP, Gollasch M, Fernandez Alfonso MS (2006) Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats, Arterioscler. Thromb. Vasc. Biol., 26: 1297-1302.
  • Gao YJ, Zeng ZH, Teoh K, Sharma AM, Abouzahr L, Cybulsky I, Lamy A, Semelhago L, Lee RM (2005) Perivascular adipose tissue modulates vascular function in the human internal thoracic artery, J. Thorac. Cardiovasc. Surg., 130: 1130-1136.
  • Gao YJ, Lu C, Su LY, Sharma AM, Lee RM (2007) Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide, Br. J. Pharmacol., 151: 323-31.
  • Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM (2002) Periadventitial fat releases a vascular relaxing factor, FASEB J., 16: 1057-1063.
  • Lu C, Zhao AX, Gao YJ, Lee RM (2011) Modulation of vein function by perivascular adipose tissue, Eur. J. Pharmacol., 657: 111-116.
  • Malinowski M, Deja MA, Golba KS, Roleder T, Biernat J, Wos S (2008) Perivascular tissue of internal thoracic artery releases potent nitric oxide and prostacyclin-independent anticontractile factor, Eur. J. Cardiothorac. Surg., 33: 225-231.
  • Oriowo MA (2015) Perivascular adipose tissue, vascular reactivity and hypertension, Med. Princ. Pract., 24: 29-37.
  • Ozen G, Topal G, Gomez I, Ghorreshi A, Boukais K, Benyahia C, Kanyinda L, Longrois D, Teskin O, Uydes-Dogan BS, Norel X (2013) Control of human vascular tone by prostanoids derived from perivascular adipose tissue, Prostaglandins. Other. Lipid. Mediat.,107:13-17.
  • Ozen G, Daci A, Norel X, Topal G (2015) Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling, Eur. J. Pharmacol., 766: 16-24.
  • Pearl JM, Manning PB, McNamara JL, Saucier MM, Thomas DW (1999) Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass, Ann. Thorac. Surg., 68: 1369-1375.
  • Sen O, Gonca S, Solakoglu S, Dalcik H, Dalcik C, Ozkara A (2013) Comparison of conventional and no-touch techniques in harvesting saphenous vein for coronary artery bypass grafting in view of endothelial damage, Heart. Surg. Forum., 16: 177-183.
  • Sepehripour AH, Jarral OA, Shipolini AR, McCormack DJ (2011) Does a ‘no-touch’ technique result in better vein patency, Interact. Cardiovasc. Thorac. Surg., 13: 626-630.
  • Soltis EE, Cassis LA (1991) Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness, Clin. Exp. Hypertens. A., 13: 277-296.
  • Souza DS, Bomfim V, Skoglund H, Dashwood MR, Borowiec JW, Bodin L, Filbey D (2001) High early patency of saphenous vein graft for coronary artery bypass harvested with surrounding tissue, Ann. Thorac. Surg., 71: 797-800.
  • Szasz T, Bomfim GF, Webb RC (2013) The influence of perivascular adipose tissue on vascular homeostasis, Vasc. Health. Risk. Manag., 9: 105-116.
  • Takemori K, Gao YJ, Ding L, Lu C, Su LY, An WS, Vinson C, Lee RM (2007) Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function, Hypertension., 49: 365-372.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Konular Eczacılık ve İlaç Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Gülsev Özen Bu kişi benim

B. Sönmez Uydeş Doğan

Önder Teskin Bu kişi benim

Xavier Norel Bu kişi benim

Gökçe Topal

Yayımlanma Tarihi 24 Ağustos 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 46 Sayı: 1

Kaynak Göster

APA Özen, G., Uydeş Doğan, B. S., Teskin, Ö., Norel, X., vd. (2016). The role of perivascular adipose tissue on human saphenous vein vascular tone. Journal of Faculty of Pharmacy of Istanbul University, 46(1), 1-13.
AMA Özen G, Uydeş Doğan BS, Teskin Ö, Norel X, Topal G. The role of perivascular adipose tissue on human saphenous vein vascular tone. Journal of Faculty of Pharmacy of Istanbul University. Ağustos 2016;46(1):1-13.
Chicago Özen, Gülsev, B. Sönmez Uydeş Doğan, Önder Teskin, Xavier Norel, ve Gökçe Topal. “The Role of Perivascular Adipose Tissue on Human Saphenous Vein Vascular Tone”. Journal of Faculty of Pharmacy of Istanbul University 46, sy. 1 (Ağustos 2016): 1-13.
EndNote Özen G, Uydeş Doğan BS, Teskin Ö, Norel X, Topal G (01 Ağustos 2016) The role of perivascular adipose tissue on human saphenous vein vascular tone. Journal of Faculty of Pharmacy of Istanbul University 46 1 1–13.
IEEE G. Özen, B. S. Uydeş Doğan, Ö. Teskin, X. Norel, ve G. Topal, “The role of perivascular adipose tissue on human saphenous vein vascular tone”, Journal of Faculty of Pharmacy of Istanbul University, c. 46, sy. 1, ss. 1–13, 2016.
ISNAD Özen, Gülsev vd. “The Role of Perivascular Adipose Tissue on Human Saphenous Vein Vascular Tone”. Journal of Faculty of Pharmacy of Istanbul University 46/1 (Ağustos 2016), 1-13.
JAMA Özen G, Uydeş Doğan BS, Teskin Ö, Norel X, Topal G. The role of perivascular adipose tissue on human saphenous vein vascular tone. Journal of Faculty of Pharmacy of Istanbul University. 2016;46:1–13.
MLA Özen, Gülsev vd. “The Role of Perivascular Adipose Tissue on Human Saphenous Vein Vascular Tone”. Journal of Faculty of Pharmacy of Istanbul University, c. 46, sy. 1, 2016, ss. 1-13.
Vancouver Özen G, Uydeş Doğan BS, Teskin Ö, Norel X, Topal G. The role of perivascular adipose tissue on human saphenous vein vascular tone. Journal of Faculty of Pharmacy of Istanbul University. 2016;46(1):1-13.