Antimikrobiyel Peptidler

Saadet Gürpınar; Şükrü Kırkan

doi:10.16988/iuvfd.33182

Antimikrobiyel Peptidler

Öz

Antimikrobiyel peptidler, bakteri, mantar, bitki, vertebralılar ve vertabrasızlardan izole edilen, birçok organizmadaki doğal savunma sistemlerinin önemli bileşenleridir. İnsanlarda bulunan proteinler ve peptidlerin birçoğu, doğal bağşıklıkta önemli rol oynayan antimikrobiyel aktiviteye sahiptir. Katelisidin ve defensinler, epidermal antimikrobiyel peptidlerin temel gruplarını oluştururlar. İn vivo ortamda son derece aktif olan antimikrobiyel peptidlerin in vitro ortamda da bakteriyel infeksiyonların tedavisinde etkili olabileceği düşünülmektedir.

Anahtar sözcükler: Bakteri, antimikrobiyel, peptid, doğal bağışıklık

ABSTRACT

ANTIMICROBIAL PEPTIDES

Antimicrobial peptides, which have been isolated from many bacteria, fungi, plants, invertebrates and vertebrates, are important components of the naturel defenses of most living organisms. A wide variety of human proteins and peptides also have antimicrobial activity and play important roles in innate immunity. Cathelicidins and defensins are major groups of epidermal antimicrobial peptides. The highly active nature of antimicrobial peptides in vitro suggests these peptides might be effective in treating bacterial infections in vivo.

Key words: Bacteria, antimicrobial, peptides, innate immunity

Anahtar Kelimeler

Bakteri, antimikrobiyel, peptid, doğal bağışıklık

Kaynakça

Bals R. 2000. Epithelial antimicrobial peptides in host defense against infections. Respiratory Research 1, 141-150.
Braff M H., Bardan A., Nizet V., Gallo R . L . 2005. Cutaneous defense mechanisms by antimicrobial peptides. Journal of Investigative Dermotology 125, 9-13 .
Brodgen K.A. 2005. Antimicrobial peptides: pore formes or metabolic inhibitors in bacteria. Natura Reviews / Microbiology 3, 239-250.
Brogden K.A., Ackermann M., McCray P.B., Tack B.F. 2003. Antimicrobial peptides in animals and their role in host defences. International Journal of Antimicrobial Agents 22, 465-478.
Heilborn J.D., Nilsson M.F., Kratz G., Weber G., Sorensen O., Borregaard N. 2003. The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. Journal of Investigative Dermotology 120, 379-389.
Ho G., Broze G.J., Schwartz A. 1997. Role of heparan sulfate proteoglycans in the uptake and degradation of tissue factor pathway inhibitor-coagulation factor Xa complexes. The Journal of Biological Chemistry 27, 16838ı 16844.
Izadpanah A., Gallo R . L . 2005. Antimicrobial Peptides. Journal of the American Academy of Dermotology 52, 381-390.
Jongstra J . , Schall T.J., Dyer B.J., Clayberger C., Jorgensen J . , Davis M.M., 1987. The isolation and sequence of a novel gene from a human functional T cell line. The Journal of Experimental Medicine 165, 601-614.

Kaspar A.A., Okada S., Kumar J . , Poulain F.R., Drouvalakis K.A., Kelekar A. 2001 . A distinct pathway of cell-mediated apoptosis initiated by granulysin. The Journal of Immunology 167, 350-356.
Koczulla R., Von Degenfeld G., Kupatt C , Krotz F., Zahler S., Gloe T. 2003. An angiogenic role for the human peptide antibiotic L L - 37/hCAP-18. The Journal of Clinical Investigation 111, 1665-1672.
Liu A.Y., Destoumieux D., Wong A.V., Park C.H., Valore E . V . , Liu L . 2002. Human beta- defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. Journal of Investigative Dermotology 118, 275-281.
Ong P.Y., Ohtake T., Brandt C., Strickland I . , Boguniewicz M., Ganz T. 2002. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. The New England Journal of Medicine 347, 1151-60.
Palffy R., Garglik R., Behuliak M., Kadasi L . , Turna J . , Celec P. 2009. On the physiology and pathophysiology of antimicrobial peptides. Molecular Medicine, 15 (1-2), 51-59
Peschel A., Jack R.W., Otto M., Collins L . V . , Staubitz P., Nicholson G. 2001. Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine. The Journal of Experimental Medicine 193, 1067-1076.
Smet K.D., Contreras R. 2005. Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnology Letters 47, 13337-13347.
Tzeng Y . L . , Ambrose K.D., Zughaier S., Zhou X., Miller Y . K . , Shafer W.M., Stephens D.S. 2005. Cationic antimicrobial peptide resistance in Neissera meningitidis. Journal of Bacteriology 187 (15), 5387-5396.
Valore E.V., Park C.H., Quayle A.J., Wiles K.R., McCray P.B.Jr., Ganz T. 1998. Human beta defensin-1: an antimicrobial peptide of urogenital tissues. The Journal of Clinical Investigation 101, 1633-1642.
Wiliams A.J.F., Gallup J.M., Romero R.R., Brodgen K.A., Ackermann M.R. 2002. Increasimg anionic peptide distribution and intensity during progression and resolution of bacterial pneumonia. Clinical and Diaonostic Laboratory Immunology 9 (1), 28-32.
Zaiou M., Nizet V., Gallo R.L. 2003. Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. Journal of Investigative Dermotology 120, 810-6.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Saadet Gürpınar

Şükrü Kırkan Bu kişi benim

Yayımlanma Tarihi

22 Aralık 2010

Gönderilme Tarihi

22 Aralık 2010

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2010 Cilt: 36 Sayı: 2

DOI

https://doi.org/10.16988/iuvfd.33182

IZ

https://izlik.org/JA46MA27TJ

Kaynak Göster

RIS / Bibtex

APA

Gürpınar, S., & Kırkan, Ş. (2010). Antimikrobiyel Peptidler. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 36(2), 61-66. https://doi.org/10.16988/iuvfd.33182

AMA

1.Gürpınar S, Kırkan Ş. Antimikrobiyel Peptidler. iuvfd. 2010;36(2):61-66. doi:10.16988/iuvfd.33182

Chicago

Gürpınar, Saadet, ve Şükrü Kırkan. 2010. “Antimikrobiyel Peptidler”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 36 (2): 61-66. https://doi.org/10.16988/iuvfd.33182.

EndNote

Gürpınar S, Kırkan Ş (01 Aralık 2010) Antimikrobiyel Peptidler. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 36 2 61–66.

IEEE

[1]S. Gürpınar ve Ş. Kırkan, “Antimikrobiyel Peptidler”, iuvfd, c. 36, sy 2, ss. 61–66, Ara. 2010, doi: 10.16988/iuvfd.33182.

ISNAD

Gürpınar, Saadet - Kırkan, Şükrü. “Antimikrobiyel Peptidler”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 36/2 (01 Aralık 2010): 61-66. https://doi.org/10.16988/iuvfd.33182.

JAMA

1.Gürpınar S, Kırkan Ş. Antimikrobiyel Peptidler. iuvfd. 2010;36:61–66.

MLA

Gürpınar, Saadet, ve Şükrü Kırkan. “Antimikrobiyel Peptidler”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, c. 36, sy 2, Aralık 2010, ss. 61-66, doi:10.16988/iuvfd.33182.

Vancouver

1.Saadet Gürpınar, Şükrü Kırkan. Antimikrobiyel Peptidler. iuvfd. 01 Aralık 2010;36(2):61-6. doi:10.16988/iuvfd.33182