KOYUNLARDA DÖL VERİMİNİ VE OVULASYON ORANINI ETKİLEYEN BMP-1B. BMP-15 VE GDF-9 GENLERİNDEKİ MUTASYONLAR

Yıl 2009, Cilt: 35 Sayı: 2, 57 - 66, 20.11.2012

Feraye Esen Gürsel

Öz

ÖZET

Koyunlar 900 farklı ırka sahip oldukları için ovulasyon oranı ve doğurganlık gibi fizyolojik özellikleri büyük çeşitlilik göstermektedir. Koyunların ovulasyon sayısındaki farklılıklar bir grup genin etkisi altındadır. Yapılan çalışmalar sonucunda koyunlardaki döl verimi üzerine etkili transforming growth factor beta (TGFβ) süper ailesinden iki adet yapısal gen ve bir TGFβ reseptör geni tespit edilmiş ve sırasıyla BMP- reseptör 1B (BMP-1B) geni, kemik morfogenetik protein geni (bone morphogenetic protein) (BMP-15) ve büyüme ayrımlaşma faktörü 9b (growth differentiation factor) (GDF-9) geni olarak isimlendirilmişlerdir. Bu makalenin amacı koyunlarda ovulasyon oranı ve döl verimi etkileyen BMP-1B, BMP-15 ve GDF-9 gen mutasyonları ile ilgili bilgileri derlemektir.

Anahtar Kelimeler: Koyun, genetik mutasyon, ovulasyon oranı, döl verimi

 

MUTATIONS IN BMP-1B, BMP-15 AND GDF-9 GENES AND THEIR EFFECTS ON FECUNDITY AND OVULATION RATE IN SHEEP

ABSTRACT

Sheep have more than 900 different breeds. Therefore their physiological characteristics including ovulation rate and fecundity, vary greatly. A group of genes effect the ovulation rates of sheep. Studies showed that there are two structural genes and one receptor gene that are the members of the transforming growth factor beta TGFP family and their names arc BMP-1B. BMP-15 and GDF-9 respectively. In this article we focus on to review the data of the BMP-1B, BMP-15 and GDF-9 gene mutations that effect sheep's ovulation rate and fecundity

Key Words: Sheep, genetic mutation, ovulation rate, fecundity

Anahtar Kelimeler

Koyun, genetik mutasyon, ovulasyon oranı, döl verimi

Kaynakça

• Bodensteiner K.J., Clay CM. , Moeller C.L., Sawyer H.R.: Molecular cloning of the ovine growth/ differentiation factor-9 gene and expression of growth/differentiation factor-9 in Ovine and Bovine Ovaries. Biol. Reprod., 1999; 60: 381-386.
• Davis G.H.: Fecundity genes in sheep. Anim. Reprod. Sci., 2004; 82-83: 247-253.
• Davis G.H.: Major genes affecting ovulation rate in sheep. Genet. Sel. Evol., 2005: 37: 11-23.
• Davis G.H., Balakrishnan L., Ross I.K., Wilson T., Galloway S.M., Lumsden B.M., Hanrahan J.P., Mullen M. , Mao X.Z., Wang G.L., Zhao Z.S., Zeng Y.Q., Robinson J.J., Mavrogenis A.P., Papachrlstoforou C, C. Baumııng P.R., Cardyn P., Boujenane I. , Cockett N.E., Eythorsdottir E., Arraıız J.J., Noter D.R.: Investigation of the Booroola (FecB) and Invcrdale (FecX1) mutations in 2İ prolific breeds and strains of sheep sampled in 13 countries. Anim. Reprod. Sci., 2006; 92 (1-2): 87-96.
• Davis G.H., Bruce G.D.. Dodds K.G.: Ovulation rate and litter size of prolific Inverdale (FecX i) and Hanna (FccX H) sheep. Proc Assoc Advancement Anim Breeding Genet. 2001;14: 175-178.
• Davis G.H., Dodds K.G., Bruce G.D.: Combined effect of the Inverdale and Booroola prolificacy genes on ovulation rate in sheep. Proc Assoc Adv Anim Breed Genet.. 1999; 13:74-77.
• Davis G.H., Dodds K.G., McEwan J.C., P.F. Fennessy: Livewcight, fleece weight and prolificacy of Romney ewes carrying the Inverdale prolificacy gene (FccX!) located on the X-chromosome. Liverst Prod Sci., 1993; 34: 83-91.
• Davis G.H., Dodds K.G., Wheeler R., Jay N.P.: Evidence That an Imprinted Gene on the X Chromosome Increases Ovulation Rate in Sheep. Biol. Reprod., 200i; 64: 216-221.
• Davis G.H., McEwan J.C., Fennessy P.F., Dodds K.G., Farquhar P.A.: Evidence for the presence of a major gene influencing ovulation rate on the X chromosome of sheep. Biol.Reprod.,1991;44: 620-624.
• Davis G.H., McEwan J.C., Fennessy P.F., Dodds K.G., McNatty K.P., O W.S.: Infertility due to bilateral ovarian hypoplasia in sheep homozygous (FecX1 FecX1) for the Inverdale prolificacy gene located on the X chromosome. Biol. Reprod., 1992; 46: 636-640.
• Davis G.H., Montgomery G.W., Allison A.J., Kelly RAV., Bray A.R.: Segregation of a major gene influencing fecundity in progeny of Booroola sheep. New Zeal. J. Agr., 1982; 25: 525-529.
• Davis, G.H., Elsen, J.M., Bodin, L., Fahmy, M.H.; Castongııay, F., Gootwine, E., Bor, A., Braw Tal, R-, Greeff, J.C., Lengyel, A., Paszthy, G., Cummins, L.: A comparison of the production from Booroola and local breed sheep in different countries. In Elsen J.M., Bodin L., Thİmonier J. (Ed), Major genes for reproduction in sheep. INRA, Paris: 315-323.
• Demir H.: Koyun ve keçi yetiştiriciliği. İstanbul, Teknik Yayınları, 1998.
• Dodds K.G., Davis G.H., Elsen J.M., Isaacs K.L., Owens J.L.: The effect of Booroola genotype on some reproductive traits in a Booroola Vlerino flock. In Elsen J.M., Bodin L., Thimonicr J. (Ed), Major genes for reproduction in sheep. 1NRA, Paris: 359-366.
• Fabre S., Pierre A., Mulsanl P, Bodin L., Di Pasquale E, Persani L, Monget P, Monniaux D.: Regulation of ovulation rate İn mammals: contribution of sheep genetic models, Reprod Biol Endocrinol., 2006; 4: 1-12.
• Galloway S.M., McNatty K. P., Cambridge L. M. , Laitinen M . P.E., Juenge! J.L. , Jokiranta T. S., McLaren R. J., Luiro K, Dodds K. G., Montgomery G.W., Beattie A. E., Davis G.H., Ritvos O.: Mutations in an oocytc-derived growth factor gene (BMPI5) cause increased ovulation rate and infertility in a dosage-sensitive manner, Nat Genet., 2000; 25: 279-283.
• Hanrahan J.P., Gregan S.M., Mulsant P., Mullen M. , Davis G.H., Powell R., Galloway S. M. : Mutations in the Genes for Oocytc-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclarc Sheep (Ovisaries). Biol. Reprod., 2004; 70: 900-909.
• Kaymakçı M. : İleri koyun Yetiştiriciliği. İzmir, Meta Basım Matbaacılık Hizmetleri, 2006.
• Logue, D.N., Gill A., MacAuslan J. , Waterhouse A., Boyd J.S., Harvey M.J.A.: The incorporation of the 'Booroola gene' into the Texel breed of sheep. Animal Breeding Abstracts, 1990: 60-3033.
• McNatty K.P., Galloway S.M., Wilson T., Smith P., Hudson N.L., O'Connell A., Bibby A.H., Heath D.A., Davis G.H., Hanrahan J.P., Juengel J.L.: Physiological effects of major genes affecting ovulation rate in sheep. Genet. Sel. Evol., 2005; 37: 25-38.
• McNatty K.P., Smith P., Moore L.G., Reader K-, Lun S„ Hanrahan J.P., Groome N.P., Laitinen M. , Ritvos O., Juengel J.L.: Oocyte-expressed genes affecting ovulation rate. Mol. Cell. Endocrinol., 2005; 234: 57-66.
• Meyer H.H, Baker R.L, Harvey T.G, Hickey S.M: Effects of Booroola Merino breeding and the Fee gene on performance of crosses with longwool breeds. 2. Effects on reproductive performance and weight of lamb weaned by young ewes. Liverst. Prod. Sci., 1994; 39 (2): 191-200.
• Montgomery G.W., Galloway S.M., Davis G.H., McNatty K.P.: Genes controlling ovulation rate in sheep. Reproduction, 2001; 121 (6): 843-852.
• Montgomery G.W., McNatty K.P., Davis G.H.: Physiology and molecular genetics of mutations that increase ovulation rate in sheep. Endocr. Rev., 1992; 13: 309-328.
• Moore R. K., Erİckson G.F., Shimasaki S.: Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals?, Trends Endocrin. Met.. 2004; 15 (8): 356-361.
• Mulsant P., Lecerf F., FabreS., Schibler L. , Monget P., Lanneluc I. , Pisselet C, Riquet J., Monniaux D., Callebaut I. , Cribiu E., Thimonier J., Teyssier J., Bodin L.. Cognİe Y., Chitour N., Elsen J.M.: Mutation in bone morphogenetic protein receptor-IB is,associated with increased ovulation rate in Booroola Merino ewes. Proc. Natl. Acad. Sci., 2001; 98:5104-5109.
• Piper L.R., Bindon B.M., Davis G.H.: The single gene inheritance of the high litter size of the Booroola Merino, in: Land R.B., Robinson D.W., Genetics of Reproduction in Sheep, Butterworths, London, UK, 1985, 115-125.
• Ponzoni R.W., Fleet M.R., Walkley J.R.W., Walker S.K.: A note on the effect of the F gene on wool production and live weight of Booroola x South Australian Merino rams. Anim. Prod., 1985; 40: 367-369.
• Sadighi M. , Bodensteiner K.J., Beattie, A. E., Galloway S.M.: Genetic mapping of ovine growth differentiation factor 9 (GDF9) to sheep chromosome 5. Anim. Genet., 2002; 33 (3):244-245.
• Shimasaki S., Moore RK., Otsuka F., Erickson G.F.: The bone morphogenetic protein system in mammalian reproduction. Endocr. Rev., 2004; 25 (1): 72-101.
• Souza C.J., MacDougall C., Campbell B.K., McN'eilly A.S., Baird D.T.: The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type I B (BMPRlB)gene. J. Endocrinol., 2001; 169(2): 1-6.
• Wilson T., Wu X.Y., Juengel J.L., Ross I.K., Lumsden J.M., Lord E.A., Dodds K.G., Walling G.A., McEwan J.C., O'Connell A.R., McNatty K.P., Montgomery GAY.: Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells. Biol. Reprod., 2001; 64: 1225-1235.