İleri Evre Küçük Hücreli Dışı Akciğer Kanserlerinde Karsinoembriyonik Antijen Düzeyinin Tedavi Yanıtı ile İlişkisi

Yıl 2024, , 3 - 8, 18.03.2024

Berna Kömürcüoğlu , Merve Ayık Türk , Bilge Salık , Mücahit Fidan , Dilek Kalenci

https://doi.org/10.57221/izmirtip.1260423

Öz

Amaç:
Serum karsinoembriyonik antijenin (CEA) yüksek düzeyleri, birçok kanser türünde kötü prognoz ile ilişkilendirilmiştir. Çalışmamızın amacı, ileri evre küçük hücreli dışı akciğer kanseri (KHDAK)’de tedavi öncesi ve sonrası serum CEA düzeylerinin tedaviye yanıt oranları ve yaşam süresiyle ilişkisini araştırmaktır.
Materiyal- Metod:
Çalışma tek merkezli, prospektif kohort olarak dizayn edildi ve toplam 85 hasta araştırıldı. İleri evre KHDAK (Evre IIIA/IIIB ve IV) tanılı 60 olguda, tedavi öncesi ve 2 kür kemoterapi sonrası serum CEA düzeyleri ile 25 sağlıklı bireyden oluşan kontrol grubundaki serum CEA düzeyleri karşılaştırıldı.
Bulgular:
KHDAK grubunda median serum CEA düzeyi 36.2 ng/ml, kontrol grubunda ise 3,65 ng/ml idi (p< 0.01). Olguların 2 kür kemoterapi sonrası RECİST kriterlerine göre yanıt değerlendirmesi yapıldı ve 23 (%38) olguda parsiyel yanıt, 19 (%32) olguda stabil hastalık ve 18 (%30) olguda progresif yanıt olarak değerlendirildi. Progresif hastalık grubunda, tedavi sonrası serum CEA düzeyleri, stabil ve parsiyel yanıt grubuna göre daha yüksekti (p=0.023).
Sonuç:
İleri evre KHDAK’de, kontrol grubuna göre serum CEA düzeylerinin yüksek olduğu ve serum CEA düzeylerinin progresif hastalık ile ilişkili olduğu bulundu. KHDAK’inde serum CEA düzeyi, tedavi yanıtı ve prognozu öngörmede kullanılabilecek bir parametre olabileceği gösterildi.

Anahtar Kelimeler

serum cae düzeyi, KHDAK, prognoz

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Yok

THE RELATIONSHIP OF CEA LEVEL WITH THE TREATMENT RESPONSE IN ADVANCED STAGE NON-SMALL CELL LUNG CANCER

Öz

Objective:
High levels of serum carcinoembryonic antigen (CEA) have been associated with poor prognosis in many types of cancer. The aim of our study is to investigate the relationship between pre- and post-treatment serum CEA levels, response rates to treatment and survival in advanced non-small cell lung cancer (NSCLC).
Material- Method:
The study was designed as a single-center, prospective cohort, and a total of 85 patients were investigated. Serum CEA levels before and after 2 cycles of chemotherapy in 60 patients with advanced NSCLC (Stage IIIA/IIIB and IV) were compared with serum CEA levels in the control group of 25 healthy individuals.
Results:
The median serum CEA level was 36.2 ng/ml in the NSCLC group and 3.65 ng/ml in the control group (p< 0.01). Response was evaluated according to RECIST criteria after 2 cycles of chemotherapy and it was evaluated as partial response in 23 (38%) patients, stable disease in 19 (32%) patients, and progressive response in 18 (30%) patients. Post-treatment serum CEA levels were higher in the progressive disease group than in the stable and partial response group (p=0.023).
Conclusion:
It was found that serum CEA levels were higher in advanced NSCLC compared to the control group and serum CEA levels were associated with progressive disease. It has been shown that serum CEA level can be a parameter that can be used to predict treatment response and prognosis in NSCLC.

Anahtar Kelimeler

serum CEA level, NSCLC, prognosis

Proje Numarası

Yok

Kaynakça

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