UTD Sınıflamasının Antenatal Hidronefroz Prognozunu Tahmin Etmedeki Rolü
Yıl 2023,
Cilt: 2 Sayı: 4, 189 - 193, 25.12.2023
Sevgin Taner
,
Gunay Ekberli
Öz
Amaç: Antenatal hidronefroz (HN), böbrek ve üriner systemin konjenital anomalilerinin (CAKUT) bir tezahürünün yanı sıra geçici bir durumu da gösterebilir. CAKUT vakalarını tanımak ve gerekli müdahaleyi zamanında yapabilmek için farklı skorlama sistemleri geliştirilmiştir. Bu çalışmanın amacı antenatal HN ile hastanemize başvuran hastaların takip sonuçlarını ‘Üriner Trakt Dilatasyonu’ (ÜTD) sınıflamasına göre yeniden değerlendirmek ve sınıflamanın prognostik öngörüsünü belirlemektir.
Gereç ve Yöntemler: Şubat 2020-Mart 2021 tarihleri arasında Adana Şehir Eğitim ve Araştırma Hastanesi Çocuk Nefroloji ve Üroloji polikliniklerine antenatal HN tanısı ile başvuran hastalar çalışmaya alındı. Hastalar UTD sınıflamasına göre gruplandırıldı.
Bulgular: Çalışmaya dahil edilen 132 hastanın (93 erkek/39 kadın) 84'ü (%64) geçici/fizyolojik hidronefroz, 48'i (%36) CAKUT tanısı aldı. Kırk yedi hastada izole pelvik dilatasyonu (pelvis ön-arka çapı <10 mm) saptandı. UTD sınıflamasına dahil edilmeyen (UTD-P0) bu hastaların dördü (%9) CAKUT tanısı aldı. CAKUT insidansı UTD-P1 grubunda %13, UTD-P2 grubunda %55 ve UTD-P3 grubunda %100 idi. UTD P3 grubunda CAKUT varlığı, böbrek fonksiyon kaybı ve cerrahi girişim gereksinimi daha sıktı.
Sonuç: UTD sınıflaması hastaların prognozunu tahmin etmede yardımcıdır. Ancak UTD sınıflamasına (P0) dahil olmayan grupta bile CAKUT olgularının varlığı bize tek bir US görüntülemenin yanıltıcı olabileceğini hatırlatmaktadır. UTD Sınıflamasına göre, herhangi bir derecede antenatal HN'si olan çocuklar, normal popülasyona kıyasla postnatal patoloji riski altındadır. Özellikle orta ve şiddetli antenatal HN, önemli bir patolojik sonuç riskine sahiptir. Bu hastaların kapsamlı doğum sonrası tanı yönetimini yürütmek önemlidir.
Kaynakça
-
References
1.Lee RS, Cendron M, Kinnamon DD, Nguyen HT.
Antenatal hydronephrosis as a predictor of postnatal
outcome: a meta-analysis. Pediatrics. 2006;118:586-93.
-
2.Blyth B, Snyder HM, Duckett JW. Antenatal diagnosis
and subsequent management of hydronephrosis. J Urol.
1993;149:693– 8.
-
3.Livera LN, Brookfield DS, Egginton JA, Hawnaur JM.
Antenatal ultrasonography to detect fetal renal
abnormalities: a prospective screening programme. BMJ.
1989;298:1421–3.
-
4.Nguyen HT, Benson CB, Bromley B, Campbell JB,
Chow J, Coleman B, et al. Multidisciplinary consensus on
the classification of prenatal and postnatal urinary tract
dilation (UTD classification system). J Pediatr
Urol.2014;10:982–8.
-
5.Scalabre A, Demede D, Gaillard S, Pracros JP,
Mouriquand P, Mure PY. Prognostic value of ultrasound
grading systems in prenatally diagnosed unilateral urinary
tract dilatation. J Urol. 2017; 197:1144–9.
-
6.Hodhod A, Capolicchio JP, Jednak R, El-Sherif E,
El-Doray Ael-A, El-Sherbiny M. Evaluation of urinary tract
dilation classification system for grading postnatal
hydronephrosis. J Urol. 2016;195:725.
Taner et al.
192
-
7.Yalcinkaya F, Ozcakar ZB. Management of antenatal
hydronephrosis. Pediatr Nephrol. 2020;35:2231-9.
-
8.Oliveira EA, Oliveira MC, Mak RH. Evaluation and
management of hydronephrosis in the neonate. Curr Opin
Pediatr. 2016;28:195-201.
-
9.Aksu N, Yavascan O, Kangin M, Kara OD, Aydin Y,
Erdogan H, et al. Postnatal management of infants with
antenatally detected hydronephrosis. Pediatr
Nephrol.2005;20:1253–9.
-
10.Signorelli M, Cerri V, Taddei F, Groli C, Bianchi UA.
Prenatal diagnosis and management of mild fetal
pyelectasis: im- plications for neonatal outcome and
follow-up. Eur J Obstet Gynecol Reprod
Biol.2005;118:154–9.
-
11.Passerotti CC, Kalish LA, Chow J, Passerotti AM,
Recabal P, Cendron M, et al. The predictive value of the
first postnatal ultrasound in children with antenatal
hydronephrosis. J Pediatr Urol. 2011;7:128-36.
-
12.Policiano C, Djokovic D, Carvalho R, Monteiro C, Melo
MA, Graça LM. Ultrasound antenatal detection of urinary
tract anomalies in the last decade: outcome and
prognosis. J Matern Fetal Neonatal Med.
2015;28:959-63.
-
13.Liang CC, Cheng PJ, Lin CJ, Chen HW, Chao AS,
Chang SD. Outcome of prenatally diagnosed fetal
hydronephrosis. J Reprod Med. 2002;47:27–32.
-
14.Skoog SJ, Peters CA, Arant BS Jr, Copp HL, Elder JS,
Hudson RG, et al. Pediatric vesicoureteral reflux
guidelines panel summary report: clinical practice
guidelines for screening siblings of children with
vesicoureteral reflux and neonates/infants with prenatal
hydronephrosis. J Urol. 2010;184:1145-51.
-
15.Braga LH, McGrath M, Farrokhyar F, Jegatheeswaran
K, Lorenzo AJ. Society for fetal urology classification vs
urinary tract dilation grading system for prognostication in
prenatal hydronephrosis: a time to resolution analysis. J
Urol. 2018;199:1615-21.
The Role of UTD Classification in Predicting Prognosis of Antenatal Hydronephrosis
Yıl 2023,
Cilt: 2 Sayı: 4, 189 - 193, 25.12.2023
Sevgin Taner
,
Gunay Ekberli
Öz
Evaluation of Patients with Antenatal Hydronephrosis According to UTD Classification
Aim: Antenatal hydronephrosis (HN) may indicate a temporary benign condition, as well as a manifestation of congenital anomalies of the kidney and urinary system (CAKUT). Different scoring systems have been introduced to recognize CAKUT cases and to perform the necessary intervention in a timely manner. The aim of this study is to reevaluate the follow-up results of patients admitted to our hospital with antenatal HN according to the Urinary Tract Dilation (UTD) classification, and to determine the prognostic prediction of the classification in determining the presence of CAKUT and the need for surgery.
Materials and Methods: Patients admitted to Adana City Training and Research Hospital Pediatric Nephrology and Urology outpatient clinics with the diagnosis of antenatal HN between February 2020-March 2021 included in the study. Patients were grouped according to the UTD classification.
Results: Of the 132 patients (93 male/39 female), 84 (64%) of the patients were evaluated as transient/physiological hydronephrosis, 48 (36%) as CAKUT. Isolated pelvic dilatation (pelvis anteroposterior diameter <10 mm) was detected in 47 patients. These patients were not included in the UTD classification (P0). Four (9%) of the UTD-P0 patients were evaluated as CAKUT. The incidence of CAKUT was 13% in patients with UTD-P1, 55% in patients with UTD-P2 and 100% in patients with UTD-P3. The diagnosis of CAKUT, loss of kidney function, and the need for surgical intervention were more common in patients in the UTD P3 group, respectively.
Conclusion: UTD classification is helpful in predicting prognosis of the patient. However, the presence of CAKUT cases even in the group not included in the UTD classification (P0) reminds us that a single US imaging can be misleading. According to the UTD Classification, children with any degree of antenatal HN are at risk for postnatal pathology compared to the normal population. Particularly moderate and severe antenatal HN has a significant risk of pathologic outcome. It is important to carry out comprehensive postnatal diagnosis management of these patients.
Kaynakça
-
References
1.Lee RS, Cendron M, Kinnamon DD, Nguyen HT.
Antenatal hydronephrosis as a predictor of postnatal
outcome: a meta-analysis. Pediatrics. 2006;118:586-93.
-
2.Blyth B, Snyder HM, Duckett JW. Antenatal diagnosis
and subsequent management of hydronephrosis. J Urol.
1993;149:693– 8.
-
3.Livera LN, Brookfield DS, Egginton JA, Hawnaur JM.
Antenatal ultrasonography to detect fetal renal
abnormalities: a prospective screening programme. BMJ.
1989;298:1421–3.
-
4.Nguyen HT, Benson CB, Bromley B, Campbell JB,
Chow J, Coleman B, et al. Multidisciplinary consensus on
the classification of prenatal and postnatal urinary tract
dilation (UTD classification system). J Pediatr
Urol.2014;10:982–8.
-
5.Scalabre A, Demede D, Gaillard S, Pracros JP,
Mouriquand P, Mure PY. Prognostic value of ultrasound
grading systems in prenatally diagnosed unilateral urinary
tract dilatation. J Urol. 2017; 197:1144–9.
-
6.Hodhod A, Capolicchio JP, Jednak R, El-Sherif E,
El-Doray Ael-A, El-Sherbiny M. Evaluation of urinary tract
dilation classification system for grading postnatal
hydronephrosis. J Urol. 2016;195:725.
Taner et al.
192
-
7.Yalcinkaya F, Ozcakar ZB. Management of antenatal
hydronephrosis. Pediatr Nephrol. 2020;35:2231-9.
-
8.Oliveira EA, Oliveira MC, Mak RH. Evaluation and
management of hydronephrosis in the neonate. Curr Opin
Pediatr. 2016;28:195-201.
-
9.Aksu N, Yavascan O, Kangin M, Kara OD, Aydin Y,
Erdogan H, et al. Postnatal management of infants with
antenatally detected hydronephrosis. Pediatr
Nephrol.2005;20:1253–9.
-
10.Signorelli M, Cerri V, Taddei F, Groli C, Bianchi UA.
Prenatal diagnosis and management of mild fetal
pyelectasis: im- plications for neonatal outcome and
follow-up. Eur J Obstet Gynecol Reprod
Biol.2005;118:154–9.
-
11.Passerotti CC, Kalish LA, Chow J, Passerotti AM,
Recabal P, Cendron M, et al. The predictive value of the
first postnatal ultrasound in children with antenatal
hydronephrosis. J Pediatr Urol. 2011;7:128-36.
-
12.Policiano C, Djokovic D, Carvalho R, Monteiro C, Melo
MA, Graça LM. Ultrasound antenatal detection of urinary
tract anomalies in the last decade: outcome and
prognosis. J Matern Fetal Neonatal Med.
2015;28:959-63.
-
13.Liang CC, Cheng PJ, Lin CJ, Chen HW, Chao AS,
Chang SD. Outcome of prenatally diagnosed fetal
hydronephrosis. J Reprod Med. 2002;47:27–32.
-
14.Skoog SJ, Peters CA, Arant BS Jr, Copp HL, Elder JS,
Hudson RG, et al. Pediatric vesicoureteral reflux
guidelines panel summary report: clinical practice
guidelines for screening siblings of children with
vesicoureteral reflux and neonates/infants with prenatal
hydronephrosis. J Urol. 2010;184:1145-51.
-
15.Braga LH, McGrath M, Farrokhyar F, Jegatheeswaran
K, Lorenzo AJ. Society for fetal urology classification vs
urinary tract dilation grading system for prognostication in
prenatal hydronephrosis: a time to resolution analysis. J
Urol. 2018;199:1615-21.