Bazal Önbeyin Kolinerjik Hücrelerinin Elektrofizyolojik Analizi

Öz

İlk mikrodiyaliz ve elektoensefalogram (EEG) çalışmalarından beri asetilkolinin bilinç üzerindeki uyarıcı etkileri bilinmektedir. Elektrofizyolojik tekniklerdeki ilerlemeler ve bu tekniklerin anatomik metodlarla harmanlanması sayesinde asetilkolinin uyanıklık süreçlerindeki rolü hakkında geçmiş bulguları destekleyici ve genişletici bilgilere ulaşılmıştır. Uyku/uyanıklık regülasyonuna ek olarak, asetilkolinin öğrenme ve bellekteki önemli rolü de yeni çalışmalarda desteklenmektedir. Kortekse asetilkolin girdisini sağlayan bazal önbeyindeki kolinerjik hücrelerin hem içsel hem de sinaptik elektrofizyolojik özelliklerini anlamak bu bağlamda çok önemlidir. Bu derleme makalesinde, bazal önbeyin kolinerjik hücreleri hakkındaki elektrofizyolojik bulgular ve literatürdeki eksiklikler tartışılmaktadır.

Anahtar Kelimeler

• Asetilkolin,nöron,nöromodülasyon,elektrofizyoloji

A Summary of Electrophysiological Research of Basal Forebrain Cholinergic Neurons

Abstract

Acetylcholine has been known to be a wake-promoting neurotransmitter since the earliest microdialysis studies coupled to electroencephalographic (EEG) measurements. Advances in electrophysiological recording tools tied to anatomical identification methods helped to unequivocally indicate that these neurons exhibit augmented activity during wake periods. Later studies have revealed that acetylcholine plays essential roles in higher cognitive functions such as learning and memory. Understanding the intrinsic and synaptic electrophysiology of basal forebrain cholinergic (BFc) neurons is of paramount importance for answering how the BFc neuron system fulfills all those functions. This review discusses the latter questions along with a summary of missing links in the current state of knowledge.

Keywords

• Acetylcholine,neuron,neuromodulation,electrophysiology

Kaynakça

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