Tissue-Specific Ameliorative Effect of Resveratrol on Oxidative Stress Parameters and Blood Lipid Profile of Mice Exposed to Cadmium
Öz
Cadmium can cause oxidative damage in organisms through overproduction of free radicals and suppression of the antioxidant defense system. Resveratrol is known as a nutraceutical with antioxidant properties accepted to have protective effects to the toxicity of heavy metals. In this study, we investigated if resveratrol could overwhelm the toxic effect of sub-acute cadmium exposure. Animals were divided to the following groups: 1) Control, 2) Vehicle control, 3) Cadmium (Cd), 4) Resveratrol (Res), 5) Exposure to both Cd and Res (Cd+Res). Increased lipid peroxidation and total sialic acids were determined in testis and lung tissues of mice exposed to Cd with the decreased in paraoxonase (PON1) level and GSH amount. Interestingly, we also found an increased lipid peroxidation and NO levels in lung tissue of mice exposed to Res and Cd + Res, but not in testis tissue. Moreover, increased triglycerides, total cholesterol, very low-density lipoproteins, and low-density lipoproteins as well as reduced high-density lipoproteins were found in mice exposed to Cd and Cd + Res compared to controls. Our results revealed that cadmium induces oxidative damage in tissues, via increased lipid peroxidation, total sialic acids and decreased antioxidant levels as well as disturbs lipid profile. Moreover, our findings indicate that resveratrol may act as “ameliorative” factor against the cadmium exposure in only testis tissue. Thus, we may suggest that ameliorative effect of resveratrol may vary depending on the exposure dose, exposure duration and exposed tissues of animals to the heavy metals.
Anahtar Kelimeler
Antioxidant defense system, Heavy Metals, Lipid Profile, Natural polyphenols, Oxidative Stress
Destekleyen Kurum
The Scientific Research Committee of Kafkas University
Proje Numarası
2016-TS-33
Teşekkür
This study was supported by Scientific Research Committee of Kafkas University (2016-TS-33). A part of this study was presented as an oral presentation at the EJONS VI-International Conference on Mathematics, Engineering, Natural and Medical Sciences, and II. Multidisciplinary Studies Congress.
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