Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji

Ahmet Erdem Dönmez

doi:10.35229/jaes.1245431

EN TR

Histopathology as a Biomarker for Monitoring Aquatic Environments

Öz

Chemical monitoring of aquatic environments helps to measure the degree of contamination in waters. However, biomonitoring tools are needed in impact assessment studies to determine the effects of pollution. Evaluation of pollution effects on various organisms, including fish, can be done using biomarker responses. Different fish species have been investigated in various biochemical studies for this purpose. The International Council for the Exploration of the Sea (ICES) also includes histopathological evaluation in the set of biomarkers used for biological evaluation in various pollutant monitoring programs. The use of histopathological techniques allows the examination of specific target organs and cells affected by exposure to environmental chemicals. The indicators examined are frequently used in fish health studies to provide information about the chronic and nonlethal effects of pollutants on the organs of fish and to evaluate the resulting stress. Because histopathological changes in fish mainly depend on water quality. They are generally more common in the investigation of polluted water ecosystems, as they are good indicators for identifying altered or contaminated environments. Changes in fish metabolism and physiology also cause changes in organ morphology. These changes can be detected by histopathological examination. In addition, by using a scoring system, it is possible to determine the level of relationship between these changes and environmental stress factors. Lesions in the gills, liver, kidney and skin tissues are the most commonly used histopathological indicators in the evaluation of the health status of fish. For these reasons, histopathological examination is also accepted as the gold standard, especially in the identification of toxicological effects. This review aims to provide an overview of the importance of histopathology as a biomarker in monitoring aquatic environments

Anahtar Kelimeler

Biomarker, Histopathology, Water Pollution

Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji

Öz

Sucul ortamların kimyasal açıdan izlenmesi, sulardaki kirlenme derecesinin ölçülmesine yardımcı olmaktadır. Bununla birlikte kirliliğin etkilerinin belirlenmesi için yapılan etki değerlendirme çalışmalarında biyoizleme araçlarına gereksinim duyulmaktadır. Balıklar dahil olmak üzere çeşitli organizmalar üzerindeki kirlilik etkilerinin değerlendirilmesi biyobelirteç yanıtlar kullanılarak yapılabilmektedir. Farklı balık türleri bu amaçla çeşitli biyokimyasal çalışmalar kapsamında araştırılmıştır. Uluslararası Deniz Keşif Konseyi (ICES) kirleticileri izleme programlarında biyolojik değerlendirme amacıyla uyguladığı biyobelirteçler setinde histopatolojik değerlendirmeye de yer vermektedir. Histopatolojik tekniklerin kullanılması, çevresel kimyasallara maruz kalma ile etkilenen belirli hedef organların ve hücrelerin incelenmesine olanak tanımaktadır. İncelenen göstergeler kirletici maddelerin, balıkların organları üzerindeki kronik ve ölümcül olmayan etkileri hakkında bilgi sağlayabilmesi ve oluşan stresinin değerlendirilmesi amaçlarıyla balık sağlığı çalışmalarında sıklıkla kullanılmaktadır. Çünkü balıklardaki histopatolojik değişiklikler esas olarak su kalitesine bağlıdır. Değişmiş veya kirlenmiş ortamların tanımlanması açısından faydalı göstergeler olduklarından, genellikle kirli su ekosistemlerinin araştırılmasında kullanımları daha yaygındır. Balık metabolizması ve fizyolojisinde meydana gelen değişiklikler organ morfolojisinde de değişikliklere neden olmaktadır. Bu değişiklikler histopatolojik inceleme yoluyla da saptanabilmektedir. Ayrıca bir skorlama sisteminin kullanılmasıyla bu değişikliklerin çevresel stres faktörleriyle ilişki düzeyinin saptanması da mümkün olmaktadır. Solungaçlar, karaciğer, böbrek ve deri dokularında oluşan lezyonlar balıkların sağlık durumunun değerlendirilmesinde en sık kullanılan histopatolojik göstergelerdir. Bu nedenlerle, özellikle toksikolojik etkilerin tanımlanmasında histopatolojik inceleme altın standart olarak da kabul edilmektedir. Bu derleme, sucul ortamların izlenmesinde bir biyobelirteç olarak histopatolojinin önemine dair genel bir değerlendirme sunmayı amaçlamaktadır.

Anahtar Kelimeler

Biyobelirteç, Histopatoloji, Su Kirliliği, Biomarker, Histopathology, Water Pollution

Kaynakça

Abdel-Moneim, A.M., Al Kahtani, M.A & Elmenshawy, O.M. (2012). Histopathological biomarkers in gills and liver of Oreochromis niloticus from polluted wetland environments Saudi Arabia. Chemosphere, 88, 1028-1035. DOI: 10.1016/j.chemosphere.2012.04.001
Abiona, O.O., Anifowose, A.J., Awojide, S.H., Adebisi, O.C., Adesina, B.T. & Ipinmoroti, M.O. (2019). Histopathological biomarking changes in the internal organs of Tilapia (Oreochromis niloticus) and Catfish (Clarias gariepinus) exposed to heavy metals contamination from Dandaru pond, Ibadan, Nigeria. Journal of Taibah University for Science, 13(1), 903-911. DOI: 10.1080/16583655.2019.1658400
Baines, C., Lerebours, A., Thomas, F., Fort, J., Kreitsberg, R., Gentes, S., Meitern, R., Saks, L., Ujvari, B., Giraudeau, M. & Sepp, T. (2021). Linking pollution and cancer in aquatic environments: A review. Environment International, 149, 106391. DOI: 10.1016/j.envint.2021.106391
Braunbeck, T., Görge, G., Storch, V. & Roland, N. (1990). Hepatic steatosis in zebra fish (Brachydanio rerio) induced by long-term exposure to γ-hexachlorocyclohexane. Ecotoxicology and Environmental Safety, 19(3), 355-374. DOI: 10.1016/0147-6513(90)90036-5
Briaudeau, T. (2019). A "biomarker + histopathology" tool box in Solea spp. for the assessment of the biological effects of pollution in the context of the EU Marine Strategy Framework Directive. International PhD Thesis, Department of Zoology and Animal Cell Biology Research Group: Cell Biology in Environmental Toxicology, Euskal Herriko Unibertsitatea, Plentzia, Spain, 252p.
Cardoso, R.L., Carvalho-Neta, R.N.F., Lealde Castro, A.C., Ferreira, C.F.C., Silva, M.H.L., Azevedo, J.W.J., Sobrinho, J.R.S.C. & Santo, D.M.S. (2018). Histological and genotoxic biomarkers in Prochilodus lacustris (Pisces, Prochilodontidae) for environmental assessment in a protected area in the northeast of Brazil. Bulletin of Environmental Contamination and Toxicology, 101, 570-579. DOI: 10.1007/s00128-018-2464-8
Dallas, L.J. & Jha, A.N. (2015). Applications of biological tools or biomarkers in aquatic biota: A case study of the Tamar Estuary, South West England. Marine Pollution Bulletin, 95(2), 618- 633. DOI: 10.1016/j.marpolbul.2015.03.014
Dalzochio, T., Zimmermann, G., Rodrigues, P., Petry, I.E., Gehlen, G. & Da Silva, L.B. (2016). The use of biomarkers to assess the health of aquatic ecosystems in Brazil: a review. International Aquatic Research, 8, 283-298. DOI: 10.1007/s40071-016-0147-9
Dane, H. & Şişman,T. (2020a). Effects of heavy metal pollution on hepatosomatic index and vital organ histology in Alburnus mossulensis from Karasu River. Turkish Journal of Veterinary & Animal Science, 44, 607-617. DOI: 10.3906/vet-1904-50
Dane, H. & Şişman, T. (2020b). A morphohistopathological study in the digestive tract of three fish species influenced with heavy metal pollution. Chemosphere, 242, 125212. DOI: 10.1016/j.chemosphere.2019.125212

Greenfield, B.K., Teh, S.J., Ross, J.R.M., Hunt, J., Zhang, G.H., Davis, J.A., Ichikawa, G., Crane, D., Hung, S.S.O., Deng, D.F., Teh, F.C. & Green, P.G. (2008). Contaminant concentrations and histopathological effects in Sacramento splittail (Pogonichthys macrolepidotus). Archives of Environmental Contamination and Toxicology, 55(2). 270-281. DOI: 10.1007/s00244-007-9112-3
Hinton, D.E. & Lauren, D.J. (1990). Liver structural alterations accompanying chronic toxicity in fishes: potential biomarkers of exposure, In: McCarthy, J.F., Shugart, L.R. (Ed.), Biomakers of Environmental Contamination, 17-57p, Lewis Publishers, Boca Raton, FL.
Hussain, B., Fatima,M., Al-Ghanim, H.A. & Mahboob, S. (2019). Environmentally induced nephrotoxicity and histopathological alternations in Wallago attu and Cirrhinus mirigla. Saudi Journal of Biological Sciences, 26, 752-757. DOI: 10.1016/j.sjbs.2019.02.003
Jaffer, N.S., Rabee, A.M. & Al-Chalabi, A.M.M. (2017). Biochemical and hematological parameters and histological alterations in fish Cyprinus carpio L. as biomarkers for water pollution with chlorpyrifos. Human and Ecological Risk Assessment, 23(3), 605-616. DOI: 10.1080/10807039.2016.1261626
Jahanbakhshi, A. & Hedayati, A. (2013). Gill histopathological changes in Great sturgeon after exposure to crude and water soluble fraction of diesel oil. Comparative Clinical Pathology, 22, 1083-1086. DOI: 10.1007/s00580-012-1531-5
Javed, M., Ahmad, I., Usmani, N. & Ahmad, M. (2016). Studies on biomarkers of oxidative stres and associated genotoxicity and histopathology in Channa punctatus from heavy metal polluted canal. Chemosphere, 151, 210-219. DOI: 10.1016/j.chemosphere.2016.02.080
Khoshnood, Z. (2017). Effects of environmental pollution on fish: a short review. Transylvanian Review of Systematical and Ecological Research, 19(1), 49- 60. DOI: 10.1515/trser-2017-0005
Kroon, F., Streten, C. & Harries, S. (2017). A protocol for identifying suitable biomarkers to assess fish health: A systematic review. Plos One, 12(4), E0174762. DOI: 10.1371/journal.pone.0174762
Lam, P., (2009). Use of biomarkers in environmental monitoring. Ocean & Coastal Management, 52(7), 348-354. DOI: 10.1016/j.ocecoaman.2009.04.010
Lionetto, M.G., Caricato, R. & Giordano, M.E. (2021). Pollution biomarkers in the framework of marine biodiversity conservation: state of art and perspectives. Water, 13, 1847. Doi: 10.3390/w13131847
Luczynska, L., Paszczyk, B. & Luczynski, M.J. (2018). Fish as a bioindicator of heavy metals pollution in aquatic ecosystem of Pluszne Lake, Poland, and risk assessment for consumer's health. Ecotoxicology and Environmental Safety, 153, 60-67. DOI: 10.1016/j.ecoenv.2018.01.057
Malik, D.S., Sharma, A.K., Sharma, A.K., Thakur, R. & Sharma, M. (2020). A review on impact of water pollution on freshwater fish species and their aquatic environment. Advances in Environmental Pollution Management: WastewaterImpacts and Treatment Technologies, 1, 10-28. DOI: 10.26832/aesa-2020-aepm-02
Monserrat, J.M., Letts, R.E., Ferreira, J.L.R., VenturaLima, J., Amado, L.L., Rocha, A.M., Gorbi, S., Bocchetti, R., Benedetti, M. & Regoli, F. (2012). Biomarkers of oxidative stress: benefits and drawbacks for their application in biomonitoring of aquatic environments, In: Abele, D., Vazquez-Medina, J.P. & Zenteno-Savin, T. (Ed), Oxidative stress in aquatic ecosystems, 1st ed., 317-326p, Blackwell Publishing Ltd., Chichester, UK.
Naz, S., Hussain, R, Ullah, Q., Chatha, A.M.M., Shaheen, A. & Khan, R.U. (2021). Toxic effect of some heavy metals on hematology and histopathology of Major Carp (Catla catla). Environmental Science and Pollution Research. 28, 6533-6539. DOI: 10.1007/s11356-020-10980-0
Oliveira Ribeiro, C.A., Filipack, F., Mela, M., Silva, P.H., Randi, M.A.F., Costa, J.R.A. & Pelletier, E. (2006). Hematological findings in neotropical fish Hoplias malabaricus exposed to subchronic and dietary doses of methylmercury, inorganic lead and tributyltin chloride. Environmental Research, 101, 74-80. DOI: 10.1016/j.envres.2005.11.005
Osman, A.G.M., Abd El Reheem, A.M, AbuelFadl, K.Y. & Gad El-Rab, A.G. (2010). Enzymatic and histopathologic biomarkers as indicators of aquatic pollution in fishes. Natural Science, 2(11), 1302-1311. DOI: 10.4236/ns.2010.211158
Parente, T.E.M. & Hauser Davies, A. (2014). The use of fish biomarkers in the evaluation of water pollution In: Almeida, E.A. & Ribeiro A.O. (Ed), Pollution and fish health in tropical ecosystems, 1st ed., 164-183p, CRC Press Taylor & Francis Group, Florida, USA.
Paul, S., Mandal, A., Bhattacharjee, P., Chakraborty, S., Paul,R. & Mukhopadhyay, B.K. (2019). Evaluation of water quality and toxicity after exposure of lead nitrate in freshwater fish, major source of water pollution. Egyptian Journal of Aquatic Research, 45, 345-351. DOI: 10.1016/j.ejar.2019.09.001
Poleksic, V., Lenhardt, M., Jaric, I., Djordjevic, D., Gacic, Z., Cvijanovic, G. & Raskovic, B. (2010). Liver, gills and skin histopathology and heavy metal content of the Danube sterlet (Acipenser ruthenus Linnaeus, 1758). Environmental Toxicology and Chemistry, 29(3), 515-21. DOI: 10.1002/etc.82
Raskovic, B., Jaric, I., Koko, V., Spasic, M., Dulic, Z., Markovic, Z. & Poleksic, V. (2013). Histopathological indicators: a useful fish health monitoring tool in common carp (Cyprinus carpio Linnaeus, 1758) culture. Central European Journal of Biology, 8 (10), 975-985. DOI: 10.2478/s11535-013-0220-y
Raskovic, B. & Poleksic, V. (2017). Fish histopathology as biomarker in ecotoxicology, In: Berillis, P. (Ed), Trends in fisheries and qquatic qnimal health, 1st ed., 155-181p. Bentham Science Publishers, Sharjah, UAE.
Ratn, A., Prasad, R., Awasthi, Y., Kumar, M., Misra, A. & Trivedi, S.P. (2018). Zn2+ induced molecular responses associated with oxidative stress, DNA damage and histopathological lesions in liver and kidney of the fish, Channa punctatus (Bloch, 1793). Ecotoxicology and Environmental Safety, 151, 10-20. DOI: 10.1016/j.ecoenv.2017.12.058
Reddy P.B. (2012). Histopathogical studies as potential and direct biomarkers of pollution. Trends in Life Sciences, 1(1), 27-31.
Reddy P.B. & Rawat, S.S. (2013). Assessment of aquatic pollution using histopathology in fish as a protocol. International Research Journal of Environment Science, 2(8), 79-82.
Ribeiro, C.A.O. & Narciso, M.F. (2014). Histopathological markers in fish health assessment. In: Almeida, E.A. & Ribeiro A.O. (Ed), Pollution and fish health in tropical ecosystems, 1st ed., 206-242p, CRC Press Taylor & Francis Group, Florida, USA.
Salamat, N., Soleimani, Z., Safahieh, E., Savari, A. & Ronagh, M.T. (2013). Using histopathological changes as a biomarker to trace contamination loading of Musa Creeks (Persian Gulf). Toxicologic Pathology, 41, 913-920. DOI: 10.1177/0192623312468515
Salamat, N. & Zarie, M. (2016). Fish histopathology as a tool for use in marine environment monitoring: a review. Comparative Clinical Pathology, 25, 1273-1278. DOI: 10.1007/s00580-014-2037-0
Saleh, Y.S. & Marie, M.A.S. (2016). Use of Arius thalassinus fish in a pollution biomonitoring study, applying combined oxidative stress, hematology, biochemical and histopathological biomarkers: A baseline field study. Marine Pollution Bulletin, 10, 6308-322. DOI: 10.1016/j.marpolbul.2016.03.030
Saraiva, A., Costa, J., Serrão, J., Cruz, C. & Eiras, J.C. (2015). A histology based fish health assessment of farmed sea bass (Dicentrarchus labrax L.). Aquaculture, 448, 375-381. DOI: 10.1016/j.aquaculture.2015.06.028
Savassi, L.A., Paschoalini, A.L., Arantes, F.P., Rizzo, E. & Bazzoli, N. (2020). Heavy metal contamination in a highly consumed Brazilian fish: immunohistochemical and histopathological assessments. Environmental Monitoring and Assessment, 192 (542). DOI: 10.1007/s10661- 020-08515-8
Schwaiger, J., Ferling, H., Mallow, U., Wintermayr, H. & Negele, R.D. (2004). Toxic effects of the nonsteroidal anti-inflammatory drug diclofenac. Part I. histopathological alterations and bioaccumulation in Rainbow trout. Aquatic Toxicology, 68, 141-150. DOI: 10.1016/j.aquatox.2004.03.014
Steckert, L.D., Cardoso, L., Jeronimo, G.T., Padua, S.B. & Martins, M.L. (2018). Investigation of farmed Nile tilapia health through histopathology. Aquaculture, 486, 161-169. DOI: 10.1016/j.aquaculture.2017.12.021
Stentiford, G.D., Massoud, M.S., Al-Mudhhi, S., AlSarawi, M.A., Al-Enezi, M. & Lyons, B.P. (2014). Histopathological survey of potential biomarkers for the assessment of contaminant related biological effects in species of fish and shellfish collected from Kuwait Bay, Arabian Gulf. Marine Environmental Research, 98, 60-67. DOI: 10.1016/j.marenvres.2014.03.005
Strzyzewska, E., Szarek, J. & Babinska, I. (2016). Morphologic evaluation of the gills as a tool in the diagnostics of pathological conditions in fish and pollution in the aquatic environment: a review. Veterinarni Medicina, 61(3), 123-132. DOI: 10.17221/8763-VETMED
Sweidan, A.H., El Bendary, N., Hegazy, O.M., Hassanien, A.E. & Snasel, V. (2015). Water Pollution Detection System based on Fish Gills as a Biomarker. Procedia Computer Science, 65, 601- 611. DOI: 10.1016/j.procs.2015.09.004
Van der Oost, R., Beyer, J. & Vermeulen, N.P.E. (2003). Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Environmental Toxicology and Pharmacology, 13(2), 57-149. Doi: 10.1016/S1382- 6689(02)00126-6
Van Dyk, J.C., Cochrane, M.J. & Wagenaar, G.M. (2012). Liver histopathology of the sharptooth catfish Clarias gariepinus as a biomarker of aquatic pollution. Chemosphere, 87, 301-311. DOI: 10.1016/j.chemosphere.2011.12.002
Vörösmarty, C.J., McIntyre, P.B., Gessner, M.O., Dudgeon, D., Prusevich, A., Green, P., Glidden, S., Bunn, S.E., Sullivan, C.A., Reidy Liermann, C., Davies, P.M. (2010) Global threats to human water security and river biodiversity. Nature, 467, 555-561. DOI: 10.1038/nature09440.
Wright, D.A. & Welbourn, P. (2002). Environmental toxicology. 1st ed., Cambridge University Press, Cambridge, UK, 630p.
Yancheva, V., Velcheva, I., Stoyanova, S. & Georgieva, E. (2016). Histological biomarkers in fish as a tool in ecological risk assessment and monitoring programs: a review. Applied Ecology and Environmental Research, 14(1), 47-75. DOI: 10.15666/aeer/1401_047075
Zeitoun M.M. & Mehana, E.E. (2014). Impact of water pollution with heavy metals on fish health: overview and updates. Global Veterinaria, 12(2), 219-231. DOI: 10.5829/idosi.gv.2014.12.02.82219.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Ahmet Erdem Dönmez ^*
0000-0001-5460-1811
Türkiye

Erken Görünüm Tarihi

13 Haziran 2023

Yayımlanma Tarihi

30 Haziran 2023

Gönderilme Tarihi

1 Şubat 2023

Kabul Tarihi

23 Mayıs 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 8 Sayı: 2

DOI

https://doi.org/10.35229/jaes.1245431

IZ

https://izlik.org/JA78MJ89YZ

APA

Dönmez, A. E. (2023). Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji. Journal of Anatolian Environmental and Animal Sciences, 8(2), 183-190. https://doi.org/10.35229/jaes.1245431

AMA

1.Dönmez AE. Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji. Journal of Anatolian Environmental and Animal Sciences. 2023;8(2):183-190. doi:10.35229/jaes.1245431

Chicago

Dönmez, Ahmet Erdem. 2023. “Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji”. Journal of Anatolian Environmental and Animal Sciences 8 (2): 183-90. https://doi.org/10.35229/jaes.1245431.

EndNote

Dönmez AE (01 Haziran 2023) Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji. Journal of Anatolian Environmental and Animal Sciences 8 2 183–190.

IEEE

[1]A. E. Dönmez, “Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji”, Journal of Anatolian Environmental and Animal Sciences, c. 8, sy 2, ss. 183–190, Haz. 2023, doi: 10.35229/jaes.1245431.

ISNAD

Dönmez, Ahmet Erdem. “Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji”. Journal of Anatolian Environmental and Animal Sciences 8/2 (01 Haziran 2023): 183-190. https://doi.org/10.35229/jaes.1245431.

JAMA

1.Dönmez AE. Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji. Journal of Anatolian Environmental and Animal Sciences. 2023;8:183–190.

MLA

Dönmez, Ahmet Erdem. “Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji”. Journal of Anatolian Environmental and Animal Sciences, c. 8, sy 2, Haziran 2023, ss. 183-90, doi:10.35229/jaes.1245431.

Vancouver

1.Ahmet Erdem Dönmez. Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji. Journal of Anatolian Environmental and Animal Sciences. 01 Haziran 2023;8(2):183-90. doi:10.35229/jaes.1245431

JAES, 2016- 11.yıl

Histopathology as a Biomarker for Monitoring Aquatic Environments

Öz

Anahtar Kelimeler

Sucul Ortamların İzlenmesinde Biyobelirteç Olarak Histopatoloji

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Erken Görünüm Tarihi

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster