Momordica Charantia'nın Sıçan Ayak İltihabı ve Davranışı Üzerine Etkilerinin İncelenmesi; deneysel Model.

Yıl 2021, , 112 - 119, 31.03.2021

Aybike Turkmen Ali Taghizadehghalehjoughi , Maryam Mohammadzadeh , Sıdıka Genç , Ahmet Hacimuftuoglu

https://doi.org/10.35229/jaes.835178

Öz

Arka plan: Ağrı, vücudun herhangi bir yerinden kaynaklanan, gerçek veya olası doku hasarı ile ilişkilendirilen ve insanın geçmiş deneyimleriyle bağlantılı hoş olmayan bir his olan yaygın deneyimlerden biridir. Momordica Charantia (MC) veya acı kavun, güçlü biyolojik etkiye sahip birçok biyoaktif bileşenin varlığından dolayı, dünyanın her yerinde başlıca diyabet, kanser ve iltihaplanma ile ilişkili durumların tedavisinde kullanılmaktadır. Çalışmamızın amacı, düşük ve yüksek dozda MC bitkisinin ayak iltihabını ve hayvan davranışını nasıl etkilediğini araştırmaktır.
Gereç ve Yöntemler: On altı erkek sıçan rastgele 4 deney grubuna ayrıldı. Ağrı modelini indüklemek için formaldehit (arka pençe formalin enjeksiyonu) uygulandı. 24 saat sonra MC (50 mg / kg, 200 mg / kg), beş gün boyunca her gün uygulandı. Deney sırasında ağrı eşikleri, motor korteks ölçümleri ve iltihaplı ayak hacmi, Lokomotor Aktivite Testi ve Su Taşma Yöntemi sırayla.
Bulgular: Sonucumuza göre kontrol grubumuzun ayak hacmi, ağrı eşiği ve motor korteks verilerini dikkate aldığımızda başlangıç ​​ile son gün arasında anlamlı bir fark yokken, 7. günde ağrı eşiği düşmeye devam ediyor Pozitif kontrol grubumuzdaki hayvanlarımızın ayak hacmi azalmadığı için. 200 mg MC konsantrasyonu artan ayak hacmini azaltarak aynı zamanda ağrı eşiğini azaltarak harika bir tedavi sağlamıştır ve motor aktivite 4. günde en yüksek seviyededir.
Sonuç: Deneyimiz, MC'nin (200 mg / ml MC) yüksek analjezik aktiviteye sahip olduğunu, belirgin ağrı azalması ve semptomlarda iyileşme sağladığını göstermektedir.

Anahtar Kelimeler

Formaldehit, Momordica charantia, Enflamasyon, motor korteks

Destekleyen Kurum

yok

Proje Numarası

yok

Investigation Of Momordica Charantia Effects On The Rat Foot Inflammation And Behavior; experimental Model.

Öz

Background: Pain is one of the common experiences which is unpleasant feeling that originates from any part of the body, is associated with real or possible tissue damage and linked to human past experiences. Momordica Charantia (MC) or bitter melon mainly is used all around the world for the treatment of diabetes, cancer and inflammation- associated conditions due to the existence of many bioactive ingredients which have vigorous biologic effect. The aim of our study is to investigate how low and high doses of MC plant affect foot inflammation and animal's behavior.
Materials and Methods: Sixteen male rats randomly divided into 4 experimental groups. Formaldehyde was (hind-paw formalin injection) administered for inducing pain model. After 24 hours MC (50 mg/kg, 200 mg/kg) was administered every day for five days. During the experiment, the pain thresholds, motor cortex measurements and inflamed foot volume, Locomotor Activity Test and Water Overflow Method in sequence.
Results: According to our result, when we consider the foot volume, pain threshold and motor cortex data of our control group, there is no significant difference between the beginning and the last day, while On the 7th day, the pain threshold continues to decrease as the foot volume of our animals in our positive control group does not decrease. 200 mg concentration of MC has provided a great treatment by reducing the increasing foot volume at the same time pain threshold and motor activity was in highest level at 4th day.
Conclusion: Our experiment shows that MC (200 mg/ml MC ) has high analgesic activity provides significant pain reduction and improvement in symptoms

Anahtar Kelimeler

Formaldehyde, Inflammation, motor cortex, Momordica Charantia

Proje Numarası

yok

Kaynakça

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