Comparison to Toxic Effects of Copper Oxide Nanoparticles and Copper Sulphate on Some Serum Parameters and Enzyme Activities of Oreochromis niloticus

Yıl 2021, , 514 - 521, 31.12.2021

Mustafa Tunçsoy , Cahit Erdem

https://doi.org/10.35229/jaes.987548

Cited By: 2

Öz

Today, human effects due to industrial development and population increase caused water ecosystems to be polluted by various pollutant such as heavy metals. Serum biochemical parameters are widely used in blood analysis and these parameters are suitable indicators for monitoring physiological changes in fish. Hence, the aim of present study to the effects of waterborne copper on serum glucose, total protein, albumin and triglyceride levels and serum cholinesterase (ChE), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkalane phosphatase (ALP) and lactate dehydrogenase (LDH) activities of O. niloticus were determined after exposing the fish to 10, 50 and 100 µg/L copper applied as CuO nanoparticles (CuO NPs) and CuSO4 over 1, 7 and 15 days.
No mortality was observed during the experiments. Serum glucose and albumin levels increased while serum total protein, cholesterol and triglyceride levels decreased compared to control at the end of the 15th day. There was also a decrease in serum ChE activity whereas serum AST, ALT, ALP and LDH activities increased. Overall, CuSO4 and CuO NPs had similar effects in serum parameters of O. niloticus.

Anahtar Kelimeler

O. niloticus, Copper oxide nanoparticles, copper sulphate, serum parameters

Destekleyen Kurum

University of Çukurova, Scientific Research Projects Coordination Unit and The Scientific and Technological Research Council of Turkey (TUBITAK)

Proje Numarası

(PhD Thesis, Project Number: FEF2013D45) and (TUBITAK Project Number: 1649B031402139)

Teşekkür

We also thanks to Prof.Dr. Maria João Bebianno, Asst.Prof.Dr. Margarida Ribau Teixeira, Dr. Tânia Gomes and Vânia Sousa.

Bakır oksit nanopartikülleri ve Bakır sülfatın O. niloticus’da Serum Parametreleri ve Serum Enzim Aktiviteleri Üzerine Toksik Etkilerinin Karşılaştırılması

Öz

Günümüzde endüstriyel gelişmeler ve nüfus artışına bağlı insan etkileri su ekosistemlerinin ağır metaller gibi çeşitli kirleticiler tarafından kirletilmesine neden olmuştur. Serum biyokimyasal parametreleri kan analizinde yaygın olarak kullanılmaktadır ve bu parametreler balıklarda fizyolojik değişikliklerin izlenmesi için uygun belirteçlerdir. Bu çalışmada 10, 50 ve 100 µg/L CuO nanopartikülleri (CuO NP) ve bakır sülfatın (CuSO4) 1, 7 ve 15 günlük sürelerle etkisinde O. niloticus’ da serum glikoz, total protein, albumin, kolesterol ve trigliserit düzeyleri ile serum ChE, AST, ALT, ALP ve LDH enzim aktivitelerinin belirlenmesi amaçlanmıştır.
Deney süresince tüm derişimlerde herhangi bir mortalite gözlenmemiştir. 15 günlük deney süresi sonunda her iki ugulamada da serum glikoz ve albümin düzeyleri artış gösterirken, serum total protein, kolesterol ve trigliserit düzeylerinde azalış gösterdiği belirlenmiştir. Serum enzim aktivitelerinde ise ChE aktivitesi azalma gösterirken, serum AST, ALT, ALP ve LDH aktiviteleri deney süresi sonunda artış göstermiştir. Sonuç olarak O. niloticus serum parametreleri üzerine toksik etkileri karşılaştırıldığında her iki uygulamanın da benzer etkiler gösterdiği belirlenmiştir.

Anahtar Kelimeler

O. niloticus, Bakır oksit nanopartikülleri, Bakır sülfat, Serum parametreleri

Proje Numarası

(PhD Thesis, Project Number: FEF2013D45) and (TUBITAK Project Number: 1649B031402139)

Kaynakça

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