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Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection

Yıl 2020, Cilt: 5 Sayı: 2, 118 - 124, 30.06.2020
https://doi.org/10.35229/jaes.690811

Öz

A pretreatment albumin (ALB)-to-globulin (GLB) ratio (AGR) with a predictive significance has been used as an indispensable marker among cancer types for recurrence and prognosis in human patients. This study aims to determine whether the pretreatment AGR and total calcium (tCa), magnesium (Mg), ionised phosphorus (iP), total protein (TP), and haematology parameters—as bedside markers—differs in dogs with naturally occurring parvovirus infection (PVI). Fourteen client-owned dogs aged 2-8 months that were naturally infected with parvovirus (PV) were enrolled as the study group. Seven client-owned, healthy dogs of the same age formed the control group. Pretreatment mean complete blood counts, serum tCa, Mg, iP, TP, ALB, globulin GLB and AGR values, were compared between groups. The pretreatment mean WBC, NEU, LYM, EOS, GLB, and TP levels were found to be significantly lower (P < 0.05) in the study group, when compared to the control group. On the other hand, pretreatment AGR with iP was found to be statistically higher (P < 0.05) in the study group, when compared to the control group. There was a significant positive correlation between mean serum GLB and WBC levels in the current study. A significant positive correlation between mean serum TP and WBC levels was also found. This preliminary study demonstrates that pretreatment serum GLB levels and the AGR—as easy, inexpensive, objective, and non-invasive biomarkers—could be the new prognostic marker candidates in dogs with naturally occurring PVI.

Teşekkür

The authors are especially thankful to Murat Bayazit and Merve Parmaksiz from Istar Consultancy, Turkey for performing the statistical analyses of this study.

Kaynakça

  • Abate, O., Zanatta, R., Malisano, T. & Dotta, U. (2000). Canine serum protein patterns using high-resolution electrophoresis (HRE). The Veterinary Journal., 159, 150-154.
  • Alberghina, D., Giannetto, C., Vazzana, I., Ferrantelli, V. & Piccione, G. (2011). Reference intervals for total protein concentration, serum protein fractions, and albumin/globulin ratios in clinically healthy dairy cows. Journal of Veterinary Diagnostic Investigation., 23, 111-114.
  • Appel, M.J.G., Cooper, B.J., Greisen, H. & Carmicheal, L.E. (1978). Status report: canine viral enteritis. Journal of the American Veterinary Medical Association., 173, 1516-1518.
  • Bossuyt, X. (2006). Advances in serum protein electrophoresis. Advances in Clinical Chemistry., 42, 43-80.
  • Castro, T.X., Rita de Cassia, N., Goncalves, L.P., Costa, E.M. & Marcello, G.C. (2013). Clinical, hematological, and biochemical findings in puppies with coronavirus and parvovirus enteritis. Canadian Veterinary Journal., 54, 885-888.
  • Chen, W.Z., Yu, S.T., Xie, R., Lv, Y.X., Xu, D.B. & Yu, J.C. (2017). Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma. Oncotarget., 8, 48240-48247.
  • Eckersall, P.D. (2008). Proteins, proteomics, and the dysproteinemias, In: Kaneko, J.J., Harvey, J.W. & Bruss, M.L. (Ed), Clinical Biochemistry of Domestic Animals. 6th ed., 117-155p, Elsevier Academic Press, California, USA.
  • Escuela, M.P., Guerra, M., Anon, J.M., Martínez-Vizcaíno, V., Zapatero, M.D., Jalon, A.G. & Celeya, S. (2005). Total and ionized serum magnesium in critically ill patients. Intensive Care Medicine., 31, 151-156.
  • Goddard, A., Leisewitz, A., Christopher, M., Duncan, N.M. & Becker, P.J. (2008). Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis. Journal of Veterinary Internal Medicine., 22, 309-316.
  • Goddard, A. & Leisewitz, A.L. (2010). Canine parvovirus. Veterinary Clinics of North America: Small Animal Practice., 40, 1041-1053.
  • He, X., Guo, S., Chen, D., Chen, X., Zhang, Y., He, Q., Quin, Z., Liu, Z., Xue, Y., Zhang, M., Liu, R., Zhou, F., Han, H. & Yao, K. (2017). Preoperative albumin to globulin ratio (AGR) as prognostic factor in renal cell carcinoma. Journal of Cancer., 8, 258-265.
  • Hoskins, J.D. (2001). Canine Viral Enteritis, In: Ettinger, S.J. (Ed), Pocket Companion to Text Book of Veterinary Internal Medicine. 5th ed., 214-218p, WB Saunders Company, Philadelphia, USA.
  • Hoskins, J.D. (1998). Canine Viral Enteritis, In: Greene, C.E. (Ed), Infectious Diseases of the Dog and Cat. 2nd ed., 40-45p, WB Saunders Company, Toronto, Ontario, USA.
  • Jacobs, R.M., Weiser, M.G., Hall, R.L. & Kowalski, J.J. (1980). Clinicopathologic features of canine parvoviral enteritis. Journal of the American Animal Hospital Association., 16, 809-814.
  • Kalli, I., Leontides, L.S., Mylonakis, M.E., Adamama-Moraitou, K., Rallis, T. & Kouitinas, A.F. (2010). Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Research in Veterinary Science., 89, 174-178.
  • Kaneko, J.J. (1997). Serum proteins and the dysproteinemias, In: Kaneko, J.J. (Ed), Clinical Biochemistry of Domestic Animals. 5th ed,. 117-138p, Academic Press, London, UK.
  • Krimer, P.M. (2011). Generating and interpreting test results: test validity, quality control, reference values, and basic epidemiology, In: Latimer, K.S. (Ed), Duncan and Prasse’s Veterinary Laboratory Medicine: Clinical Pathology. 5th ed., 365-382p, Wiley-Blackwell, Chichester.
  • Lin, Q., Lin, Z., Chen, J., Lin, J.X., Li, X., Jiang J.R., Ma, X.K., Wu, D.H., Chen, Z.H., Dong, M., Wei, L., Wang, T.T., Ruan, D.Y., Lin, Z.X., Wen, J.Y., Wu, X.Y. & Huang, M.S. (2017). Prognostic significance of preoperative albumin-to-globulin ratio in patients with cholangiocarcinoma. Current Research in Translational Medicine., 65, 83-87.
  • Ling, M., Norris, J.M., Kelman, M. & Ward, M.P. (2012). Risk factors for death from canine parvoviral related disease in Australia. Veterinary Microbiology., 158, 280-290.
  • Mann, F., Boon, G., Wagner-Mann, C., Ruben, D.S. & Harrington, D.P. (1998). Ionized and total magnesium concentrations in blood from dogs with naturally acquired parvoviral enteritis. Journal of the American Veterinary Medical Association., 212, 1398-1401.
  • Mazzaferro, E.M., Rudloff, E. & Kirby, R. (2002). The role of albumin replacement in the critically ill veterinary patient. Journal of Veterinary Emergency and Critical Care., 12, 113-124.
  • McCaw, D.L. & Hoskins, J.D. (2006). Canine viral enteritis, In: Greene, C.E. (Ed), Infectious Diseases of the Dog and Cat. 3trd ed., 63-73p, Saunders Elsevier, St. Louis.
  • McClure, V., Schoor, M.. Thompson, P.N., Kjelgaard-Hansen, M. & Goddard, A. (2013). Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus. Journal of the American Veterinary Medical Association., 243, 361-366.
  • Mohr, A.J., Leisewitz, A.L., Jacobson, L.S., Steiner, J.M., Ruaux, C.G. & Williams, D.A. (2003). Effect of early enteral nutrition on intestinal permeability, intestinal protein loss, and outcome in dogs with severe parvoviral enteritis. Journal of Veterinary Internal Medicine., 17, 791-798.
  • Okutucu, B., Dincer, A., Habib, O. & Zihnioglu, F. (2007). Comparison of five methods for determination of total plasma protein concentration. Journal of Biochemical and Biophysical Methods., 70, 709-711.
  • Otto, C.M., Rieser, T.M., Brooks, M.B. & Russell, M.W. (2000). Evidence of hypercoagulability in dogs with parvoviral enteritis. Journal of the American Veterinary Medical Association., 217, 1500-1504.
  • Prittie, J. (2004). Canine parvoviral enteritis: a review of diagnosis, management, and prevention. Journal of Veterinary Internal Medicine., 14, 167-176.
  • Rørtveit, R., Sævik, B.K., Eggertsdottir, A.V., Skancke, E. & Lingaas, F. (2015). Age-related changes in hematologic and serum biochemical variables in dogs aged 16–60 days. Veterinary Clinical Pathology., 44, 47-57.
  • Schoeman, J.P., Goddard, A. & Leisewitz, A.L. (2013). Biomarkers in canine parvovirus enteritis. New Zealand Veterinary Journal., 61, 217-222.
  • Shibutani, M., Maeda, K., Nagahara, H., Ohtani, H., Iseki, Y., Ikeya, T., Sugano, K. & Hirakawa, K. (2015). The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer. BMC Cancer., 15, 347.
  • Sugimoto, K., Komiyama, H., Kojima, Y., Goto, M., Tomiki, Y. & Sakamoto, K. (2012). Glasgow prognostic score as a prognostic factor in patients undergoing curative surgery for colorectal cancer. Digestive Surgery., 29, 503-509.
  • Tothova, C., Nagy, O. & Kovac, G. (2016). Serum proteins and their diagnostic utility in veterinary medicine: A review. Veterinární Medicína., 61, 475-496.
  • Van den Broek, A.H.M. (1990). Serum protein electrophoresis in canine parvovirus enteritis. British Veterinary Journal., 146, 255-259.
  • Weaver, D.M., Tyler, J.W., Van Metre, D.C., Hostetler, D.E. & Barrington, G.M. (2000). Passive transfer of colostral immunoglobulins in calves. Journal of Veterinary Internal Medicine., 14, 569-577.
  • Yilmaz, Z. & Senturk, S. (2007). Characterization of lipid profiles in dogs with parvoviral enteritis. Journal of Small Animal Practice., 48, 643-650.
  • Zhou T, He X, Fang W, Zhan J, Hong S, Qin, T., Ma, Y., Sheng, J., Zhou, N., Zhao, Y., Huang, Y. & Zhang, L. (2016). Pretreatment albumin/globulin ratio predicts the prognosis for small-cell lung cancer. Medicine (Baltimore)., 95, e3097.
Yıl 2020, Cilt: 5 Sayı: 2, 118 - 124, 30.06.2020
https://doi.org/10.35229/jaes.690811

Öz

Kaynakça

  • Abate, O., Zanatta, R., Malisano, T. & Dotta, U. (2000). Canine serum protein patterns using high-resolution electrophoresis (HRE). The Veterinary Journal., 159, 150-154.
  • Alberghina, D., Giannetto, C., Vazzana, I., Ferrantelli, V. & Piccione, G. (2011). Reference intervals for total protein concentration, serum protein fractions, and albumin/globulin ratios in clinically healthy dairy cows. Journal of Veterinary Diagnostic Investigation., 23, 111-114.
  • Appel, M.J.G., Cooper, B.J., Greisen, H. & Carmicheal, L.E. (1978). Status report: canine viral enteritis. Journal of the American Veterinary Medical Association., 173, 1516-1518.
  • Bossuyt, X. (2006). Advances in serum protein electrophoresis. Advances in Clinical Chemistry., 42, 43-80.
  • Castro, T.X., Rita de Cassia, N., Goncalves, L.P., Costa, E.M. & Marcello, G.C. (2013). Clinical, hematological, and biochemical findings in puppies with coronavirus and parvovirus enteritis. Canadian Veterinary Journal., 54, 885-888.
  • Chen, W.Z., Yu, S.T., Xie, R., Lv, Y.X., Xu, D.B. & Yu, J.C. (2017). Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma. Oncotarget., 8, 48240-48247.
  • Eckersall, P.D. (2008). Proteins, proteomics, and the dysproteinemias, In: Kaneko, J.J., Harvey, J.W. & Bruss, M.L. (Ed), Clinical Biochemistry of Domestic Animals. 6th ed., 117-155p, Elsevier Academic Press, California, USA.
  • Escuela, M.P., Guerra, M., Anon, J.M., Martínez-Vizcaíno, V., Zapatero, M.D., Jalon, A.G. & Celeya, S. (2005). Total and ionized serum magnesium in critically ill patients. Intensive Care Medicine., 31, 151-156.
  • Goddard, A., Leisewitz, A., Christopher, M., Duncan, N.M. & Becker, P.J. (2008). Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis. Journal of Veterinary Internal Medicine., 22, 309-316.
  • Goddard, A. & Leisewitz, A.L. (2010). Canine parvovirus. Veterinary Clinics of North America: Small Animal Practice., 40, 1041-1053.
  • He, X., Guo, S., Chen, D., Chen, X., Zhang, Y., He, Q., Quin, Z., Liu, Z., Xue, Y., Zhang, M., Liu, R., Zhou, F., Han, H. & Yao, K. (2017). Preoperative albumin to globulin ratio (AGR) as prognostic factor in renal cell carcinoma. Journal of Cancer., 8, 258-265.
  • Hoskins, J.D. (2001). Canine Viral Enteritis, In: Ettinger, S.J. (Ed), Pocket Companion to Text Book of Veterinary Internal Medicine. 5th ed., 214-218p, WB Saunders Company, Philadelphia, USA.
  • Hoskins, J.D. (1998). Canine Viral Enteritis, In: Greene, C.E. (Ed), Infectious Diseases of the Dog and Cat. 2nd ed., 40-45p, WB Saunders Company, Toronto, Ontario, USA.
  • Jacobs, R.M., Weiser, M.G., Hall, R.L. & Kowalski, J.J. (1980). Clinicopathologic features of canine parvoviral enteritis. Journal of the American Animal Hospital Association., 16, 809-814.
  • Kalli, I., Leontides, L.S., Mylonakis, M.E., Adamama-Moraitou, K., Rallis, T. & Kouitinas, A.F. (2010). Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Research in Veterinary Science., 89, 174-178.
  • Kaneko, J.J. (1997). Serum proteins and the dysproteinemias, In: Kaneko, J.J. (Ed), Clinical Biochemistry of Domestic Animals. 5th ed,. 117-138p, Academic Press, London, UK.
  • Krimer, P.M. (2011). Generating and interpreting test results: test validity, quality control, reference values, and basic epidemiology, In: Latimer, K.S. (Ed), Duncan and Prasse’s Veterinary Laboratory Medicine: Clinical Pathology. 5th ed., 365-382p, Wiley-Blackwell, Chichester.
  • Lin, Q., Lin, Z., Chen, J., Lin, J.X., Li, X., Jiang J.R., Ma, X.K., Wu, D.H., Chen, Z.H., Dong, M., Wei, L., Wang, T.T., Ruan, D.Y., Lin, Z.X., Wen, J.Y., Wu, X.Y. & Huang, M.S. (2017). Prognostic significance of preoperative albumin-to-globulin ratio in patients with cholangiocarcinoma. Current Research in Translational Medicine., 65, 83-87.
  • Ling, M., Norris, J.M., Kelman, M. & Ward, M.P. (2012). Risk factors for death from canine parvoviral related disease in Australia. Veterinary Microbiology., 158, 280-290.
  • Mann, F., Boon, G., Wagner-Mann, C., Ruben, D.S. & Harrington, D.P. (1998). Ionized and total magnesium concentrations in blood from dogs with naturally acquired parvoviral enteritis. Journal of the American Veterinary Medical Association., 212, 1398-1401.
  • Mazzaferro, E.M., Rudloff, E. & Kirby, R. (2002). The role of albumin replacement in the critically ill veterinary patient. Journal of Veterinary Emergency and Critical Care., 12, 113-124.
  • McCaw, D.L. & Hoskins, J.D. (2006). Canine viral enteritis, In: Greene, C.E. (Ed), Infectious Diseases of the Dog and Cat. 3trd ed., 63-73p, Saunders Elsevier, St. Louis.
  • McClure, V., Schoor, M.. Thompson, P.N., Kjelgaard-Hansen, M. & Goddard, A. (2013). Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus. Journal of the American Veterinary Medical Association., 243, 361-366.
  • Mohr, A.J., Leisewitz, A.L., Jacobson, L.S., Steiner, J.M., Ruaux, C.G. & Williams, D.A. (2003). Effect of early enteral nutrition on intestinal permeability, intestinal protein loss, and outcome in dogs with severe parvoviral enteritis. Journal of Veterinary Internal Medicine., 17, 791-798.
  • Okutucu, B., Dincer, A., Habib, O. & Zihnioglu, F. (2007). Comparison of five methods for determination of total plasma protein concentration. Journal of Biochemical and Biophysical Methods., 70, 709-711.
  • Otto, C.M., Rieser, T.M., Brooks, M.B. & Russell, M.W. (2000). Evidence of hypercoagulability in dogs with parvoviral enteritis. Journal of the American Veterinary Medical Association., 217, 1500-1504.
  • Prittie, J. (2004). Canine parvoviral enteritis: a review of diagnosis, management, and prevention. Journal of Veterinary Internal Medicine., 14, 167-176.
  • Rørtveit, R., Sævik, B.K., Eggertsdottir, A.V., Skancke, E. & Lingaas, F. (2015). Age-related changes in hematologic and serum biochemical variables in dogs aged 16–60 days. Veterinary Clinical Pathology., 44, 47-57.
  • Schoeman, J.P., Goddard, A. & Leisewitz, A.L. (2013). Biomarkers in canine parvovirus enteritis. New Zealand Veterinary Journal., 61, 217-222.
  • Shibutani, M., Maeda, K., Nagahara, H., Ohtani, H., Iseki, Y., Ikeya, T., Sugano, K. & Hirakawa, K. (2015). The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer. BMC Cancer., 15, 347.
  • Sugimoto, K., Komiyama, H., Kojima, Y., Goto, M., Tomiki, Y. & Sakamoto, K. (2012). Glasgow prognostic score as a prognostic factor in patients undergoing curative surgery for colorectal cancer. Digestive Surgery., 29, 503-509.
  • Tothova, C., Nagy, O. & Kovac, G. (2016). Serum proteins and their diagnostic utility in veterinary medicine: A review. Veterinární Medicína., 61, 475-496.
  • Van den Broek, A.H.M. (1990). Serum protein electrophoresis in canine parvovirus enteritis. British Veterinary Journal., 146, 255-259.
  • Weaver, D.M., Tyler, J.W., Van Metre, D.C., Hostetler, D.E. & Barrington, G.M. (2000). Passive transfer of colostral immunoglobulins in calves. Journal of Veterinary Internal Medicine., 14, 569-577.
  • Yilmaz, Z. & Senturk, S. (2007). Characterization of lipid profiles in dogs with parvoviral enteritis. Journal of Small Animal Practice., 48, 643-650.
  • Zhou T, He X, Fang W, Zhan J, Hong S, Qin, T., Ma, Y., Sheng, J., Zhou, N., Zhao, Y., Huang, Y. & Zhang, L. (2016). Pretreatment albumin/globulin ratio predicts the prognosis for small-cell lung cancer. Medicine (Baltimore)., 95, e3097.
Toplam 36 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Didem Pekmezci 0000-0003-2072-8165

Kübra Çakır 0000-0001-7488-1400

Yayımlanma Tarihi 30 Haziran 2020
Gönderilme Tarihi 19 Şubat 2020
Kabul Tarihi 3 Nisan 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 5 Sayı: 2

Kaynak Göster

APA Pekmezci, D., & Çakır, K. (2020). Evaluation of Pretreatment Serum Albumin-to-Globulin Ratio in Dogs with Naturally Occurring Parvovirus Infection. Journal of Anatolian Environmental and Animal Sciences, 5(2), 118-124. https://doi.org/10.35229/jaes.690811


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