The Effect of Secondary Bacterial Infections on Hemogram Values and Behavior in Dogs with Distemper
Yıl 2025,
Cilt: 10 Sayı: 1, 40 - 47
Derya Karataş Yeni
,
Yavuzkan Paksoy
,
Duygu Arslan
,
Muhammed Can Gökmen
Öz
The aim of this study was to investigate the negative effects of secondary bacterial infections on animal behaviour and prognosis in puppies infected with canine distemper virus infection. The study was conducted in Hatay Alfa Vet Veterinary Clinic between June 2023 and June 2024 and some behaviours of 35 puppies were followed. In the study, the mortality rate of puppies infected with canine distemper virus infection was determined as 28.6%. The involvement of secondary bacterial infections increased the mortality rate (43%). It was determined that age and breed positively affected the mortality rate in addition to increasing the possibility of contracting bacterial and viral diseases. Central nervous system disorders and abnormal behaviour have been observed in dogs with viral infections. Secondary bacterial infections have been found to increase the severity of the disease, symptoms and behavioural disorders. It was determined that bacterial and viral infections can be prevented with appropriate care, feeding, hygiene, individual housing and regular vaccination programmes. In conclusion, it was determined that secondary bacterial infections increase the severity and mortality rate of viral infections, animals with infections develop abnormal behaviours and prevention of diseases is more important than treatment.
Kaynakça
- Atalay Vural, S. & Alcıgır, M.E. (2010). Distemper
virus-induced apoptotic changes in cerebellum.
Ankara Üniversitesi Veteriner Fakültesi Dergisi,
57, 83-86.
- Beadling, C. & Slifka, M.K. (2004). How do viral
infections predispose patients to bacterial
infections? Current opinion in infectious diseases.
17(3), 185-191.
- Beineke, A., Puff, C., Seehusen, F. & Baumgärtner, W.
(2009). Pathogenesis and immunopathology of
systemic and nervous canine distemper.
Veterinary Immunology and Immunopathology,
127(1-2), 1-18.
- Blancou, J. (2004). Dog distemper: imported into Europe
from South America. Historia Medicinae
Veterinariae, 29(2), 35-41.
- Carmichael, L.E. & Binn, L.N. (1981). New canine
enteric viral infection. Adv. Vet. Sci., 25, 1-37.
- Carvalho, O.V., Botelho, C.V., Torres Ferreira, C.G. &
Scherer, P.O. (2012). Immunopathogenic and
neurological mechanisms of canine distemper
virus. Advances in Virology, 2012(1), 163860.
- Cho, H. & Park, N. (2005). Detection of canine distemper
virus in blood samples by reverse transcription
loop‐mediated isothermal amplification. Journal
of Veterinary Medicine, Series B, 52(9), 410-413.
- Costa, V.G.D., Saivish, M.V., Rodrigues, R.L., Lima
Silva, R.F.D., Moreli, M.L. & Krüger, R.H.
(2019). Molecular and serological surveys of
canine distemper virus: A meta-analysis of cross-
sectional studies. PloS One, 14(5), e0217594.
DOI: 10.1371/journal.pone.0217594
- Elia, G., Camero, M., Losurdo, M., Lucente, M.S.,
Larocca, V., Martella, V., Decaro, N. &
Buonavoglia, C. (2015). Virological and
serological findings in dogs with naturally
occurring distemper. Journal of Virological
Methods, 213, 127-130.
- Gámiz, C., Martella, V., Ulloa, R., Fajardo, R.,
Quijano-Hernandéz, I. & Martínez, S. (2011).
Identification of a new genotype of canine
distemper virus circulating in America.
Veterinary Research Communications, 35, 381-
390.
- Greene, C.E.& Appel, M.J. (2006). Canine Distemper.
In: Infectious diseases of dog and cat., 3rd ed.
Greene, C.E. Saunders Elsevier, St. Louis,
Missouri, 25-41pp.
- Harper, E.J., Hackett, R.M., Wilkinson, J. & Heaton,
P.R. (2003). Age-related variations in
hematologic and plasma biochemical test results
in Beagles and Labrador Retrievers. J Am Vet Med
Assoc., 223(10), 1436-42. DOI:
10.2460/javma.2003.223.1436 PMID: 14627092.
- Hart, B.L. & Hart, L.A. (2019). Sickness behavior in
animals: implications for health and wellness.
Encyclopedia of Animal Behavior, 1.
- Headley, S.A., Graça, D.L., Matiuzzi da Costa, M. &
Castagna de Vargas, A. (1999). Infecção pelo
virus da cinomose com pneumonia secundária por
Bordetella bronchiseptica em cães. Ciência Rural,
29, 741-743.
- Headley, S.A. & Graça, D.L. (2000). Canine distemper:
epidemiological findings of 250 cases. Brazilian
Journal of Veterinary Research and Animal
Science, 37, 136-140.
- Jones, T. & Hunt, R. (1983). Veterinary pathology. Lea
and Febiger. Inc., Philadelphia. 904-905.
- Horzinek, M.C. (2010). Vaccination protocols for
companion animals: the veterinarian's
perspective. Journal of Comparative Pathology,
142, 129-132.
- Hoskins, J.D. (2010). Canine Viral Disease. In: Ettinger
SJ, Feldman EC, editors. Textbook of Veterinary
İnternal Medicine: Disease of the Dog and Cat.
7th ed. Canada, Elsevier, 961-2.
- Elgalfy, G.E., El-Raof, A., Mahmoud, Y., Ghanem,
M.M. & El-khaiat, H.M. (2022). Clinical,
Hematological, Acute phase proteins and
Radiographic changes in different respiratory
affections in dogs and cats. Benha Veterinary
Medical Journal, 42(1), 80-85.
- Karataş Yeni, D., Paksoy, Y. & Koluman, N. (2024).
Hayvan Davranışları ve Hastalık Belirteçleri.
Bidge Yayınları, 1. Baskı.
- Kim, D., Jeoung, Y., Ahn, J., Lee, H., Pak, S. & Kwon,
H. (2006). Comparision of tissue and fluid
samples for the early detection of canine
distemper virus in experimentally infected dogs.
Journal of Veterinary Medical Science, 68(8),
877-879.
- Koutinas, A.F., Baumgärtner, W., Tontis, D. &
Polizopoulou, Z. (2004). Histopathology and
immunohistochemistry of canine distemper virus-
induced footpad hyperkeratosis (hard pad disease)
in dogs with natural canine distemper. Veterinary
Pathology, 41(1), 2-9.
- Lechner, E.S., Crawford, P.C., Levy, J.K., Edinboro,
C.H., Dubovi, E.J. & Caligiuri, R. (2010).
Prevalence of protective antibody titers for canine
distemper virus and canine parvovirus in dogs
entering a Florida animal shelter. Journal of the
American Veterinary Medical Association,
236(12), 1317-1321.
- Martella, V., Elia, G. & Buonavoglia, C. (2008). Canine
distemper virus. Veterinary Clinics of North
America: Small Animal Practice, 38(4), 787-797.
Martínez-Gutierrez, M. & Ruiz-Saenz, J. (2016).
- Diversity of susceptible hosts in canine distemper
virus infection: a systematic review and data
synthesis. BMC Veterinary Research, 12, 78.
- Mahajan, S., Dey, S., Kumar, A., Panigrahi, P. &
Karunanithy, M. (2018). Association and risk of
canine distemper with respect to age, sex and
breed of dogs suffering from demyelinating
neuropathies. Int. J. Livest. Res., 8, 164-171.
- Moritz, A., Frisk, A.L. & Baumgärtner, W. (2000). The
evaluation of diagnostic procedures for the
detection of canine distemper virus infection. The
European Journal of Companion Animal
Practice, 10, 37-47.
- Newbury, S. (2021). Canine distemper virus. Infectious
Disease Management in Animal Shelters, 256-73.
- Nikolic, S., Belic, B., Cincovic, M., Novakov, N., Plavsa,
N. & Savic, S. (2022). The effects of biological
and health characteristics of dogs on
intraindividual variabilityof blood parameters.
Turkish Journal of Veterinary & Animal Sciences:
46(3), Article 3.
- Pekmezci, D., Konaçoğlu, G.N. & Çolak Z.N. (2022). A
Preliminary Study for Determination of
Neutrophil to Lymphocyte, Monocyte to
Lymphocyte and Platelet to Lymphocyte Ratios in
Dogs with Canine Distemper Virus Infection.
Journal of Anatolian Environmental and Animal
Sciences. 7(4), 437-443.
- Reddy, H.T. & Shenoy, B. (2023). Mechanisms of
secondary bacterial infections in viral infections.
Pediatric Infectious Disease, 5(4),. 126-128.
- Rendon-Marin, S., Budaszewski, R.F., Canal, C.W. &
Ruiz-Saenz, J. (2019). Tropism and molecular
pathogenesis of canine distemper virus. Virology
Journal. 16, 1-15.
- Rikula, U.K. (2008). Canine distemper in Finland:
vaccination and epidemiology.
- Rossiter, P., Williams, E.S., Munson, L. & Kennedy, S.
(2001). Morbilliviral diseases. Infectious
Diseases of Wild Mammals. 37-76 p.
- Sayın, Y. & Erol, N. (2021). Investigation of canine
distemper virus infection in dogs in the Antalya
province. Animal Health Production and
Hygiene. 10(2), 45-51.
- Sykes, J.E. & Vandevelde, M. (2021). Canine distemper
virus infection, in Greene's infectious diseases of
the dog and cat. Elsevier. 271-288p.
- Şahna, K.C., Atalay, Ö. & Gencay Göksu, A. (2008).
Viral etilogy of diarrhoea in puppies from a same
shelter in Turkey, presence of mixed infections.
Revue de Mèdecine Vètèrinaire. 159, 345-347.
- Shabbir, M.Z., Rabbani, M., Ahmad, A., Ahmed, A.,
Muhammad, K. & Anwar, I. (2010).
Comparative evaluation of clinical samples from
naturally infected dogs for early detection of
canine distemper virus. Turkish Journal of
Veterinary & Animal Sciences, 34(6), 547-552.
- Tipold, A., Vandevelde, M. & Jaggy, A. (1992).
Neurological manifestations of canine distemper
virus infection. Journal of Small Animal Practice,
33(10), 466-470.
- Willi, B., Spiri, M., Grimm, F. & Meri, M.L. (2015).
Clinical and molecular investigation of a canine
distemper outbreak and vector-borne infections in
a group of rescue dogs imported from Hungary to
Switzerland. BMC Veterinary Research. 16, 114-
154.
- Zacarias, J., Dimande, A., Acha, S., Dias, P.T., Leonal,
E.M., Messa, A., Macucule, B., Junior, J.L. &
Bila, C.G. (2016). Severe canine distemper
outbreak in unvaccinated dogs in Mozambique.
Journal of South African Veterinary Assocciation,
87(1), 1350.
Distemperli Köpeklerde Sekonder Bakteriyel Enfeksiyonların Hemogram Değerleri ve Davranışlar Üzerine Etkisi
Yıl 2025,
Cilt: 10 Sayı: 1, 40 - 47
Derya Karataş Yeni
,
Yavuzkan Paksoy
,
Duygu Arslan
,
Muhammed Can Gökmen
Öz
Bu çalışma, canine distemper virüs enfeksiyonuna yakalanmış yavru köpeklerde sekonder bakteriyel enfeksiyonların hayvan davranışları üzerine olumsuz etkileri ve hastalığın prognozuna etkisinin incelenmesi amacı ile yapılmıştır. Araştırma, Hatay Alfa Vet Veteriner Kliniği’nde Haziran 2023 - Haziran 2024 tarihleri arasında yürütülmüş olup toplam 35 yavru köpeğin bazı davranışları takip edilmiştir. Çalışmada canin distemper virüs enfeksiyonuna yakalanan yavru köpeklerde ölüm oranı % 28,6 olarak belirlenmiştir. Sekonder bakteriyel enfeksiyonların olaya müdahil olması ölüm oranını arttırmıştır (% 43). Yaş ve ırkın bakteriyel ve viral hastalıklara yakalanma ihtimalini arttırmasına ek olarak ölüm oranını pozitif etkilediği tespit edilmiştir. Viral enfeksiyona sahip köpeklerde merkezi sinir sistemi rahatsızlıkları ve anormal davranışlar gözlenmiştir. Sekonder bakteriyel enfeksiyonların hastalığın şiddetini, semptomlarını ve davranış bozukluklarını arttırdığı tespit edilmiştir. Uygun bakım besleme, hijyen kurallarına uyma, bireysel barındırma ve düzenli aşı programları ile bakteriyel ve viral enfeksiyonların önüne geçilebileceği belirlenmiştir. Sonuç olarak, sekonder bakteriyel enfeksiyonların viral enfeksiyonların şiddetini ve ölüm oranını arttırdığı, enfeksiyonlara sahip olan hayvanların anormal davranışlar geliştirdiği ve hastalıklardan korunmanın tedaviden daha önemli olduğu belirlenmiştir.
Kaynakça
- Atalay Vural, S. & Alcıgır, M.E. (2010). Distemper
virus-induced apoptotic changes in cerebellum.
Ankara Üniversitesi Veteriner Fakültesi Dergisi,
57, 83-86.
- Beadling, C. & Slifka, M.K. (2004). How do viral
infections predispose patients to bacterial
infections? Current opinion in infectious diseases.
17(3), 185-191.
- Beineke, A., Puff, C., Seehusen, F. & Baumgärtner, W.
(2009). Pathogenesis and immunopathology of
systemic and nervous canine distemper.
Veterinary Immunology and Immunopathology,
127(1-2), 1-18.
- Blancou, J. (2004). Dog distemper: imported into Europe
from South America. Historia Medicinae
Veterinariae, 29(2), 35-41.
- Carmichael, L.E. & Binn, L.N. (1981). New canine
enteric viral infection. Adv. Vet. Sci., 25, 1-37.
- Carvalho, O.V., Botelho, C.V., Torres Ferreira, C.G. &
Scherer, P.O. (2012). Immunopathogenic and
neurological mechanisms of canine distemper
virus. Advances in Virology, 2012(1), 163860.
- Cho, H. & Park, N. (2005). Detection of canine distemper
virus in blood samples by reverse transcription
loop‐mediated isothermal amplification. Journal
of Veterinary Medicine, Series B, 52(9), 410-413.
- Costa, V.G.D., Saivish, M.V., Rodrigues, R.L., Lima
Silva, R.F.D., Moreli, M.L. & Krüger, R.H.
(2019). Molecular and serological surveys of
canine distemper virus: A meta-analysis of cross-
sectional studies. PloS One, 14(5), e0217594.
DOI: 10.1371/journal.pone.0217594
- Elia, G., Camero, M., Losurdo, M., Lucente, M.S.,
Larocca, V., Martella, V., Decaro, N. &
Buonavoglia, C. (2015). Virological and
serological findings in dogs with naturally
occurring distemper. Journal of Virological
Methods, 213, 127-130.
- Gámiz, C., Martella, V., Ulloa, R., Fajardo, R.,
Quijano-Hernandéz, I. & Martínez, S. (2011).
Identification of a new genotype of canine
distemper virus circulating in America.
Veterinary Research Communications, 35, 381-
390.
- Greene, C.E.& Appel, M.J. (2006). Canine Distemper.
In: Infectious diseases of dog and cat., 3rd ed.
Greene, C.E. Saunders Elsevier, St. Louis,
Missouri, 25-41pp.
- Harper, E.J., Hackett, R.M., Wilkinson, J. & Heaton,
P.R. (2003). Age-related variations in
hematologic and plasma biochemical test results
in Beagles and Labrador Retrievers. J Am Vet Med
Assoc., 223(10), 1436-42. DOI:
10.2460/javma.2003.223.1436 PMID: 14627092.
- Hart, B.L. & Hart, L.A. (2019). Sickness behavior in
animals: implications for health and wellness.
Encyclopedia of Animal Behavior, 1.
- Headley, S.A., Graça, D.L., Matiuzzi da Costa, M. &
Castagna de Vargas, A. (1999). Infecção pelo
virus da cinomose com pneumonia secundária por
Bordetella bronchiseptica em cães. Ciência Rural,
29, 741-743.
- Headley, S.A. & Graça, D.L. (2000). Canine distemper:
epidemiological findings of 250 cases. Brazilian
Journal of Veterinary Research and Animal
Science, 37, 136-140.
- Jones, T. & Hunt, R. (1983). Veterinary pathology. Lea
and Febiger. Inc., Philadelphia. 904-905.
- Horzinek, M.C. (2010). Vaccination protocols for
companion animals: the veterinarian's
perspective. Journal of Comparative Pathology,
142, 129-132.
- Hoskins, J.D. (2010). Canine Viral Disease. In: Ettinger
SJ, Feldman EC, editors. Textbook of Veterinary
İnternal Medicine: Disease of the Dog and Cat.
7th ed. Canada, Elsevier, 961-2.
- Elgalfy, G.E., El-Raof, A., Mahmoud, Y., Ghanem,
M.M. & El-khaiat, H.M. (2022). Clinical,
Hematological, Acute phase proteins and
Radiographic changes in different respiratory
affections in dogs and cats. Benha Veterinary
Medical Journal, 42(1), 80-85.
- Karataş Yeni, D., Paksoy, Y. & Koluman, N. (2024).
Hayvan Davranışları ve Hastalık Belirteçleri.
Bidge Yayınları, 1. Baskı.
- Kim, D., Jeoung, Y., Ahn, J., Lee, H., Pak, S. & Kwon,
H. (2006). Comparision of tissue and fluid
samples for the early detection of canine
distemper virus in experimentally infected dogs.
Journal of Veterinary Medical Science, 68(8),
877-879.
- Koutinas, A.F., Baumgärtner, W., Tontis, D. &
Polizopoulou, Z. (2004). Histopathology and
immunohistochemistry of canine distemper virus-
induced footpad hyperkeratosis (hard pad disease)
in dogs with natural canine distemper. Veterinary
Pathology, 41(1), 2-9.
- Lechner, E.S., Crawford, P.C., Levy, J.K., Edinboro,
C.H., Dubovi, E.J. & Caligiuri, R. (2010).
Prevalence of protective antibody titers for canine
distemper virus and canine parvovirus in dogs
entering a Florida animal shelter. Journal of the
American Veterinary Medical Association,
236(12), 1317-1321.
- Martella, V., Elia, G. & Buonavoglia, C. (2008). Canine
distemper virus. Veterinary Clinics of North
America: Small Animal Practice, 38(4), 787-797.
Martínez-Gutierrez, M. & Ruiz-Saenz, J. (2016).
- Diversity of susceptible hosts in canine distemper
virus infection: a systematic review and data
synthesis. BMC Veterinary Research, 12, 78.
- Mahajan, S., Dey, S., Kumar, A., Panigrahi, P. &
Karunanithy, M. (2018). Association and risk of
canine distemper with respect to age, sex and
breed of dogs suffering from demyelinating
neuropathies. Int. J. Livest. Res., 8, 164-171.
- Moritz, A., Frisk, A.L. & Baumgärtner, W. (2000). The
evaluation of diagnostic procedures for the
detection of canine distemper virus infection. The
European Journal of Companion Animal
Practice, 10, 37-47.
- Newbury, S. (2021). Canine distemper virus. Infectious
Disease Management in Animal Shelters, 256-73.
- Nikolic, S., Belic, B., Cincovic, M., Novakov, N., Plavsa,
N. & Savic, S. (2022). The effects of biological
and health characteristics of dogs on
intraindividual variabilityof blood parameters.
Turkish Journal of Veterinary & Animal Sciences:
46(3), Article 3.
- Pekmezci, D., Konaçoğlu, G.N. & Çolak Z.N. (2022). A
Preliminary Study for Determination of
Neutrophil to Lymphocyte, Monocyte to
Lymphocyte and Platelet to Lymphocyte Ratios in
Dogs with Canine Distemper Virus Infection.
Journal of Anatolian Environmental and Animal
Sciences. 7(4), 437-443.
- Reddy, H.T. & Shenoy, B. (2023). Mechanisms of
secondary bacterial infections in viral infections.
Pediatric Infectious Disease, 5(4),. 126-128.
- Rendon-Marin, S., Budaszewski, R.F., Canal, C.W. &
Ruiz-Saenz, J. (2019). Tropism and molecular
pathogenesis of canine distemper virus. Virology
Journal. 16, 1-15.
- Rikula, U.K. (2008). Canine distemper in Finland:
vaccination and epidemiology.
- Rossiter, P., Williams, E.S., Munson, L. & Kennedy, S.
(2001). Morbilliviral diseases. Infectious
Diseases of Wild Mammals. 37-76 p.
- Sayın, Y. & Erol, N. (2021). Investigation of canine
distemper virus infection in dogs in the Antalya
province. Animal Health Production and
Hygiene. 10(2), 45-51.
- Sykes, J.E. & Vandevelde, M. (2021). Canine distemper
virus infection, in Greene's infectious diseases of
the dog and cat. Elsevier. 271-288p.
- Şahna, K.C., Atalay, Ö. & Gencay Göksu, A. (2008).
Viral etilogy of diarrhoea in puppies from a same
shelter in Turkey, presence of mixed infections.
Revue de Mèdecine Vètèrinaire. 159, 345-347.
- Shabbir, M.Z., Rabbani, M., Ahmad, A., Ahmed, A.,
Muhammad, K. & Anwar, I. (2010).
Comparative evaluation of clinical samples from
naturally infected dogs for early detection of
canine distemper virus. Turkish Journal of
Veterinary & Animal Sciences, 34(6), 547-552.
- Tipold, A., Vandevelde, M. & Jaggy, A. (1992).
Neurological manifestations of canine distemper
virus infection. Journal of Small Animal Practice,
33(10), 466-470.
- Willi, B., Spiri, M., Grimm, F. & Meri, M.L. (2015).
Clinical and molecular investigation of a canine
distemper outbreak and vector-borne infections in
a group of rescue dogs imported from Hungary to
Switzerland. BMC Veterinary Research. 16, 114-
154.
- Zacarias, J., Dimande, A., Acha, S., Dias, P.T., Leonal,
E.M., Messa, A., Macucule, B., Junior, J.L. &
Bila, C.G. (2016). Severe canine distemper
outbreak in unvaccinated dogs in Mozambique.
Journal of South African Veterinary Assocciation,
87(1), 1350.