Atopik Dermatit Tedavisinde Biyolojik İlaçlar: Literatür Taraması

Öz

Atopik dermatit; kronik, kaşıntılı, inflamatuar bir deri hastalığıdır. Pediatrik dönemde ve erişkinlik döneminde görülebilen atopik dermatit; kaşıntı, kaşıntıya bağlı uyku bozuklukları, sosyal geri çekilme ve tedavi maliyetleri açısından hastanın yaşam kalitesini doğrudan etkilemektedir. Topikal tedaviler, fototerapi yöntemleri, sistemik immünsupresif ilaçlar ve biyolojik ajanlar atopik dermatit tedavisinde kullanılmaktadır. Biyolojik ajanlar; hızlı etki başlangıçları ve kaşıntının sürdürülebilir kontrolünde oldukça önemli bir rol üstlenmektedir. Semptomların kontrolünde etkili ilaçlar olmaları ve konvansiyonel immünsupresif ilaçlara göre daha az yan etkiye sahip olmaları sebebiyle biyolojik ajanlar atopik dermatit tedavisinde gelecekte daha sık kullanılabilir. Atopik dermatit tedavisi ile ilgili araştırmalar sürdükçe yeni biyolojik ilaçlar üretilmeye ve kullanılmaya devam edecektir. Atopik dermatit tedavisinde kullanılan biyolojik ajanların faz çalışmalarının sonuçlarını ve gerçek yaşam verilerini sentezleyerek paylaşmak istiyoruz. Farklı mekanizmalar üzerinden ilaçların etkilerini, vaka sonuçlarını, karşılaşılan yan etkileri, tedavi sürdürülebilirliğini ve uzun dönem risklerini bir bütün olarak ortaya koymayı ve tartışmayı amaçlıyoruz.

Anahtar Kelimeler

• Atopik
• antikorlar
• dermatit
• monoklonal

Biological Drugs in the Treatment of Atopic Dermatitis: A Literature Review

Öz

Atopic dermatitis is a chronic, pruritic, inflammatory skin condition that affects both children and adults, significantly impacting patients’ quality of life due to itching, sleep disturbances caused by itching, social withdrawal, and treatment expenses. The treatment of atopic dermatitis involves various approaches, including topical therapies, phototherapy, systemic immunosuppressants, and biological agents. Biologics are particularly noteworthy for their rapid onset of action and sustained ability to manage pruritus. Given their effectiveness in symptom control and lower incidence of adverse effects compared to traditional immunosuppressive medications, biological drugs are likely to see increased utilization in the future for treating atopic dermatitis. Ongoing research in this field is expected to lead to the development and utilization of novel biologics. This study aims to provide a comprehensive overview of phase studies and real-world data on the use of biological agents in atopic dermatitis treatment. The objective is to analyze and discuss the drugs’ effects based on their mechanisms of action, clinical outcomes, side effect profiles, treatment durability, and long-term safety considerations.

Anahtar Kelimeler

• Atopic
• antibodies
• dermatitis
• monoclonal

Kaynakça

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