Evaluation of Hematologic Parameters in Patients with Obstructive Sleep Apnea Syndrome; Single Center Experience

Öz

Aim: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by complete or partial obstruction of the upper airways and impaired airflow, resulting in pauses in breathing or decreased airflow. The aim of our study was to evaluate the hematologic parameters of patients who applied to the Sleep Center and underwent polysomnography for OSAS. Materials and Methods: In this study, we reviewed the files of 351 patients aged 18 years and older who applied to the Sleep Center and underwent polysomnography for OSAS. Patients were grouped as simple snoring or OSAS according to ApneaHypopnea index. Hematologic parameters of the patients were recorded from their files. Changes in these parameters with the presence of OSAS were evaluated. Results: 271 patients were diagnosed with OSAS, while 78 patients were considered to have simple snoring. The mean age of the patients diagnosed with OSAS was 50.46±11.08 years. There were statistically significant differences between the groups in white blood cell count, mean platelet volume and erythrocyte distribution width, but not in hemoglobin level, neutrophil count, lymphocyte count and neutrophil to lymphocyte ratio. Conclusion: OSAS is a chronic disease that may cause changes in hematologic findings. Prospective study of changes in hematologic findings in a larger group of patients may allow us to determine the answer to the question of who should prioritize a difficult to access test such as polysomnography with a cheaper and easily accessible test.

Anahtar Kelimeler

• mean platelet volume
• neutrophils
• sleep apnea

Obstruktif Uyku Apne Sendromu Tanılı Hastalarda Hematolojik Parametrelerin Değerlendirilmesi; Tek Merkez Deneyimi

Öz

Amaç: Obstruktif uyku apne sendromu (OUAS), üst solunum yollarında tam veya kısmi tıkanma ile hava akışının bozulması ile solunumda duraksama veya hava akışında azalmayla karakterize bir hastalıktır. OUAS’ta sistemik inflamatuvar belirteçlerin arttığı ve buna bağlı hematolojik parametrelerde değişiklik olabileceği bilinmektedir. Çalışmamızda amacımız Uyku Merkezine başvuran ve OUAS düşünülerek polisomnografi yapılan hastaların hematolojik parametrelerini değerlendirmektir. Gereç ve Yöntemler: Bu çalışmada Uyku Merkezine başvuran ve OUAS düşünülerek polisomnografi yapılan, 18 yaş ve üzeri 351 hastanın dosyası tarandı. Hastalar Apne-Hipopne indeksine göre basit horlama veya OUAS olarak gruplandı. Hastaların hematolojik parametreleri dosyalarından kaydedildi. OUAS varlığı ile bu parametrelerdeki değişiklikler değerlendirildi. Bulgular: 271 hasta OUAS tanısı alırken, 78 hasta basit horlama kabul edildi. OUAS tanısı alan hastaların yaş ortalaması 50,46±11,08 idi. Beyaz küre sayısı, ortalama trombosit hacmi ve eritrosit dağılım genişliği açısından gruplar arasında istatistiksel olarak anlamlı fark saptanırken, hemoglobin düzeyi, nötrofil sayısı, lenfosit sayısı ve nötrofil lenfosit oranı açısından fark yoktu. Sonuç: OUAS hematolojik bulgularda değişikliklere neden olabilecek kronik bir hastalıktır. Hematolojik bulgularda oluşabilecek değişikliklerin daha büyük hasta grubunda, prospektif olarak yapılması, polisomnografi gibi zor ulaşılan bir tetkiki kimlere daha öncelikli yapalım sorusunun yanıtını daha ucuz ve kolay ulaşılabilir bir testle belirlememize olanak verebilir.

Anahtar Kelimeler

• Uyku apne
• Ortalama Trombosit Hacmi
• Nötrofil

Kaynakça

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