KEMİK İLİĞİNDE SPLENİK MARJİNAL ZON LENFOMA: BİR OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ

Öz

Marjinal zon lenfomalar (MZL), sekonder lenfoid foliküllerin marjinal bölgesinde B lenfositlerinden kaynaklanan nadir görülen düşük dereceli B lenfomalarıdır. Nodüler Hodgkin lenfomalarının (NHL) %1'inden azını oluştururlar. Dünya Sağlık Örgütü'nün sınıflamasına göre marjinal bölge lenfomalar üç gruba ayrılır: ekstranodal MALT lenfoma, dalak MZL (SMZL) ve nodal MZL. Her üç grupta da kromozomal, genetik ve immünfenotibik benzerlikler vardır. SMZL genellikle kemik iliği ve dalak hilar lenf düğümleri tutan bir lenfomadır. Dalak periferik kan ve bazen karaciğer infiltrasyon gösterir, ve genellikle yaşamın altıncı on yılında ortaya çıkar. Tedavi için standart bir yaklaşım yoktur. Hastaların üçte ikisi tanı sırasında asemptomatiktir ve hastaların önemli bir kısmı başarılı bir şekilde splenektomi ile tedavi edilir.

Anahtar Kelimeler

• Splenik marjinal zon lenfoma
• kemik iliği

Splenic Marginal Zone Lymphoma In Bone Marrow:A Case Report And Review Of The Literature

Öz

Marginal zone lymphomas (MZL) are rare low-grade B lymphomas that originate from B lymphocytes in the marginal zone of the secondary lymphoid follicles. They comprise less than 1% of Nodular Hodgkin lymphomas (NHL). According to the World Health Organization’s classification, marginal zone lymphomas are divided into three groups: extranodal MALT lymphoma, splenic MZL (SMZL), and nodal MZL. All three groups have chromosomal, genetic, and immunophenotypic similarities. SMZL is a lymphoma that typically involves the bone marrow and hilar lymph nodes of the spleen. The spleen shows infiltration to peripheral blood and sometimes the liver, and usually occurs in the sixth decade of life. There is no standardized approach for treatment. Two-thirds of patients are asymptomatic during diagnosis, anda significant proportion of patients are successfully treated with a splenectomy.

Anahtar Kelimeler

• Splenic Marginal Zone Lymphoma
• bone marrow
• review

Kaynakça

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