Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2020, Cilt: 5 Sayı: 1, 19 - 24, 01.04.2020

Öz

Proje Numarası

09D05101003

Kaynakça

  • 1-Bosch FX, de Sanjose S. Human papillomavirusandcervicalcancer—burdenandassessment of causality. J NatlCancerInstMonogr 2003; 31:3–13.
  • 2-Sand PK, Bowen LW, Blischke SO, Ostergard DR. Evaluation of maleconsortsofwomenwith genital humanpapillomavirusinfection. ObstetGynecol 1986 Nov;68(5):679–81.
  • 3-Kennedy L, Buntine DW, O'Connor D, Frazer IH. Human papillomavirus--a study of malesexualpartners. Med J Aust 1988 Sep 19;149(6):309–11.
  • 4-Bleeker MCG, Heideman DAM, Snijders PJF, Horenblas S, Dillner J, Meijer CJLM. Penilecancer: epidemiology, pathogenesisandprevention. World J Urol2009;27:141–50. http://dx.doi.org/10.1007/ s00345-008-0302-z.
  • 5-Ventimiglia E, Horenblas S, Muneer A, Salonia A. Human PapillomavirusInfectionandVaccination in Males. EurUrolFocus. 2016 Oct;2(4):355-362. doi:10.1016/j.euf.2016.08.012. Epub 2016 Sep 12. Review. PubMed PMID: 28723467.
  • 6-Taner MZ, Taskiran C, Onan MA, Uluturk A, Himmetoglu O. Genital humanpapillomavirusinfection in themalesexualpartners of womenwithisolatedvulvarlesions. Int J GynecolCancer. 2006;16(2):791–794. doi:10.1111/j.1525-1438.2006.00376.x
  • 7-Hippeläinen M, Syrjänen S, Hippeläinen M, Koskela H, Pulkkinen J, Saarikoski S, Syrjänen K. et al. Prevalance and risk factors of genital human papillomavirus (İPV) infections in healthy males. A study on Finnish conscripts. Sex Transm Dis 1993;20:321-328
  • 8-Forslund O, Hansson BG, Rymark P, Bjerre B. Human papillomavirus DNA in urine samples compared with that in simultaneously collected urethra and cervix samples. J Clin Microbiol 1993;31:1975-1979.
  • 9-Astori G, Pipan C, Muffato G, Botta GA. Detection of HPV DNA in semen, urine and urethral samples by dot blot and PCR. Microbiologica 1995;18:143-149.
  • 10-Aguilar LV, Lazcano-Ponce E, Vaccarella S, Cruz A, Hernández P, Smith JS, Muñoz N, Kornegay JR, Hernández-Avila M, Franceschi S. Human papillomavirus in men: comparison of different genital sites. Sex Transm Infect 2006;82:31-33.
  • 11-Smith JS, Moses S, Hudgens MG, Agot K, Franceschi S, Maclean IW, Ndinya-Achola JO, Parker CB, Pugh N, Meijer CJ, Snijders PJ, Bailey RC. Human Papillomavirus Detection by Penile Site in Young Men from Kenya. Sex Transm Dis. 2007 November ; 34(11): 928–934.
  • 12-Kataoka A, Claesson U, Hansson BG, Eriksson M, Lindh E. Human papillomavirus infection of the male dianosed by Southern-blot hybridization and polymerase chain reaction. Comparison between urethral samples and penile biyopsy samples. J Med Virol 1991;33:159-164.
  • 13- Della Torre G, Donghi R, de Campos Lima PO, et al. Human papillomavirus genomes in male urethral cells. Am J Pathol1992; 141:1181.
  • 14-Cecchini S, Cipparrone I, Confortini M, Scuderi A, Meini L, Piazzesi G. Urethral cytology of Cytobursh specimens. Anew technique for detecting subclinical human papilomavirus infection in men. Acta Cytol 1988;32:314-317.
  • 15-Aynaud O, Ionesco M, Barrasso R. Cytologic detection of human papillomavirus DNA in normal male urethral samples. Urology 2003;61:1098-1101.
  • 16-Gushi A, Kanekura T, Kanzaki T, Eizuru Y. Detection and sequences of human papillomavirus DNA in nongenitalseborrhoeic keratosis of immunopotent individuals. Journal of Dermatological Science. 2003; 31: 143-149.
  • 17-Ko CJ, Iftner T, Barr RJ, Binder SW. Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma . J CutanPathol 2007: 34: 44–48.
  • 18-Rombaldi RL, Serafini EP, Villa LL, Vanni AC, Baréa F, Frassini R, Xavier M, Paesi S. Infection with human papillomaviruses of sexual partners of women having cervical intraepithelial neoplasia.Braz J Med Biol Res. 2006 Feb;39(2):177-87.
  • 19-M I Hippelainen, S Syrjfnen, MJ Hippelainen, S Saarikoski, K Syrjanen. Diagnosis of genital human papillomavirus (HPV) lesions in the male: Correlation of peniscopy, histology and in situ hybridisation. Genitourin Med 1993;69:346-351.
  • 20-Bar-Am A, Niv J, Jaffo A, Peyser RM. Prevalence of human papillomavirus infection and HPV DNA among male partners of Israeli women with genital premalignant and human papillomavirus lesions. Isr J Med Sci. 1995 Jun;31(6):349-52.
  • 21-Rubin MA, Kleter B, Zhou M, Ayala G, Cubilla AL, Quint WG, Pirog EC. Detection and Typing of Human Papillomavirus DNA in Penile Carcinoma Evidence for Multiple Independent Pathways of Penile Carcinogenesis. Am J Pathol. 2001 Oct;159(4):1211
  • 22-Nielson CM, Flores R, Harris RB, Abrahamsen M, Papenfuss MR, Dunne EF, Markowitz LE, Giuliano AR. Human papillomavirusprevalenceandtypedistribution in maleanogenitalsitesand semen. CancerEpidemiolBiomarkersPrev. 2007 Jun;16(6):1107-14.

Ürogenital Kondilom Lezyonu Olan Erkek Hastalarda Lezyonda ve Üretral Sürüntü Örneğinde İPV Tanısı ve Tiplendirmesi

Yıl 2020, Cilt: 5 Sayı: 1, 19 - 24, 01.04.2020

Öz

Amaç: Ürogenital kondilomu olan erkek hastalarda İnsan Papilloma Virus (İPV) enfeksiyon varlığının tespitinde üretral sürüntü örneklerinin etkinliğini değerlendirmek ve mevcut olan bu enfeksiyonlarının sık görülen onkolojik tip olan İPV–16 ile olan ilişkisini ortaya koymak amaçlanmıştır.
Materyal-Metot: Kliniğimize ürogenital siğil şikâyeti ile başvuran cinsel olarak aktif, immunsupresif tedavi veya kemoterapi öyküsü olmayan erkek hastalar dahil edildi. Eksternal meatusda tespit edilen lezyonlar eksize edildi. Üretroskopi yapılarak üretrada başka lezyon olmadığı gösterildi. Kutanöz lezyonların belirgin olanları dokuda eksize edildi. Küçük lezyonlar elektrokoter ile koterize edildi. Tüm hastalardan viral tanı ve tiplendirme amacıyla üretral sürüntü örneği alındı. Elde edilen dokular virolojik çalışma ve patolojik incelemeye gönderilmek üzere ikiye ayrıldı. İPV tanısı için dokuda ve sürüntü örneklerinde polimeraz zincir reaksiyonu uygulandı.
Bulgular: Ortalama yaşı 34,9±9 yıl olan 34 hasta çalışmaya dahil edildi. 3 hastada eksternal meatusda verrüköz leyzon tespit edildi. 30 hastada patolojik inceleme sonucunda kondilom tespit edildi.1 hastada eşlik eden karsinoma in situ mevcuttu. 4 hastada ise seboreikkeratoz (2) ve akantoz (2) tespit edildi. Dokulardan yapılan virolojik çalışmalarda 18 hastada İPV varlığı gösterildi. İPV 16 mikst enfeskiyon gözlenen 6 örnekte gösterildi. İPV-16 varlığı malign ve benign lezyonlarda gösterildi (karsinoma in situ 1 hasta, akantoz 1 hasta). Üretral sürüntü örneklerinde ise 6 hastada İPV varlığı gösterildi. Üretral sürüntüde İPV (+) olan 2 hastanın doku örneğinde İPV(-)'ti.
Sonuç: İPV tanısında ve tiplendirmede üretral sürüntü örnekleri doku örnekleri kadar yeterli görünmemektedir.

Destekleyen Kurum

Hacettepe Üniversitesi, Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

09D05101003

Kaynakça

  • 1-Bosch FX, de Sanjose S. Human papillomavirusandcervicalcancer—burdenandassessment of causality. J NatlCancerInstMonogr 2003; 31:3–13.
  • 2-Sand PK, Bowen LW, Blischke SO, Ostergard DR. Evaluation of maleconsortsofwomenwith genital humanpapillomavirusinfection. ObstetGynecol 1986 Nov;68(5):679–81.
  • 3-Kennedy L, Buntine DW, O'Connor D, Frazer IH. Human papillomavirus--a study of malesexualpartners. Med J Aust 1988 Sep 19;149(6):309–11.
  • 4-Bleeker MCG, Heideman DAM, Snijders PJF, Horenblas S, Dillner J, Meijer CJLM. Penilecancer: epidemiology, pathogenesisandprevention. World J Urol2009;27:141–50. http://dx.doi.org/10.1007/ s00345-008-0302-z.
  • 5-Ventimiglia E, Horenblas S, Muneer A, Salonia A. Human PapillomavirusInfectionandVaccination in Males. EurUrolFocus. 2016 Oct;2(4):355-362. doi:10.1016/j.euf.2016.08.012. Epub 2016 Sep 12. Review. PubMed PMID: 28723467.
  • 6-Taner MZ, Taskiran C, Onan MA, Uluturk A, Himmetoglu O. Genital humanpapillomavirusinfection in themalesexualpartners of womenwithisolatedvulvarlesions. Int J GynecolCancer. 2006;16(2):791–794. doi:10.1111/j.1525-1438.2006.00376.x
  • 7-Hippeläinen M, Syrjänen S, Hippeläinen M, Koskela H, Pulkkinen J, Saarikoski S, Syrjänen K. et al. Prevalance and risk factors of genital human papillomavirus (İPV) infections in healthy males. A study on Finnish conscripts. Sex Transm Dis 1993;20:321-328
  • 8-Forslund O, Hansson BG, Rymark P, Bjerre B. Human papillomavirus DNA in urine samples compared with that in simultaneously collected urethra and cervix samples. J Clin Microbiol 1993;31:1975-1979.
  • 9-Astori G, Pipan C, Muffato G, Botta GA. Detection of HPV DNA in semen, urine and urethral samples by dot blot and PCR. Microbiologica 1995;18:143-149.
  • 10-Aguilar LV, Lazcano-Ponce E, Vaccarella S, Cruz A, Hernández P, Smith JS, Muñoz N, Kornegay JR, Hernández-Avila M, Franceschi S. Human papillomavirus in men: comparison of different genital sites. Sex Transm Infect 2006;82:31-33.
  • 11-Smith JS, Moses S, Hudgens MG, Agot K, Franceschi S, Maclean IW, Ndinya-Achola JO, Parker CB, Pugh N, Meijer CJ, Snijders PJ, Bailey RC. Human Papillomavirus Detection by Penile Site in Young Men from Kenya. Sex Transm Dis. 2007 November ; 34(11): 928–934.
  • 12-Kataoka A, Claesson U, Hansson BG, Eriksson M, Lindh E. Human papillomavirus infection of the male dianosed by Southern-blot hybridization and polymerase chain reaction. Comparison between urethral samples and penile biyopsy samples. J Med Virol 1991;33:159-164.
  • 13- Della Torre G, Donghi R, de Campos Lima PO, et al. Human papillomavirus genomes in male urethral cells. Am J Pathol1992; 141:1181.
  • 14-Cecchini S, Cipparrone I, Confortini M, Scuderi A, Meini L, Piazzesi G. Urethral cytology of Cytobursh specimens. Anew technique for detecting subclinical human papilomavirus infection in men. Acta Cytol 1988;32:314-317.
  • 15-Aynaud O, Ionesco M, Barrasso R. Cytologic detection of human papillomavirus DNA in normal male urethral samples. Urology 2003;61:1098-1101.
  • 16-Gushi A, Kanekura T, Kanzaki T, Eizuru Y. Detection and sequences of human papillomavirus DNA in nongenitalseborrhoeic keratosis of immunopotent individuals. Journal of Dermatological Science. 2003; 31: 143-149.
  • 17-Ko CJ, Iftner T, Barr RJ, Binder SW. Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma . J CutanPathol 2007: 34: 44–48.
  • 18-Rombaldi RL, Serafini EP, Villa LL, Vanni AC, Baréa F, Frassini R, Xavier M, Paesi S. Infection with human papillomaviruses of sexual partners of women having cervical intraepithelial neoplasia.Braz J Med Biol Res. 2006 Feb;39(2):177-87.
  • 19-M I Hippelainen, S Syrjfnen, MJ Hippelainen, S Saarikoski, K Syrjanen. Diagnosis of genital human papillomavirus (HPV) lesions in the male: Correlation of peniscopy, histology and in situ hybridisation. Genitourin Med 1993;69:346-351.
  • 20-Bar-Am A, Niv J, Jaffo A, Peyser RM. Prevalence of human papillomavirus infection and HPV DNA among male partners of Israeli women with genital premalignant and human papillomavirus lesions. Isr J Med Sci. 1995 Jun;31(6):349-52.
  • 21-Rubin MA, Kleter B, Zhou M, Ayala G, Cubilla AL, Quint WG, Pirog EC. Detection and Typing of Human Papillomavirus DNA in Penile Carcinoma Evidence for Multiple Independent Pathways of Penile Carcinogenesis. Am J Pathol. 2001 Oct;159(4):1211
  • 22-Nielson CM, Flores R, Harris RB, Abrahamsen M, Papenfuss MR, Dunne EF, Markowitz LE, Giuliano AR. Human papillomavirusprevalenceandtypedistribution in maleanogenitalsitesand semen. CancerEpidemiolBiomarkersPrev. 2007 Jun;16(6):1107-14.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Makale
Yazarlar

Şevket Tolga Tombul 0000-0002-5398-4088

Bülent Akdoğan 0000-0001-6717-7677

Koray Ergünay 0000-0001-5422-1982

Dilek Ertoy Baydar 0000-0003-0784-8605

İlhan Erkan 0000-0003-1932-3849

Proje Numarası 09D05101003
Yayımlanma Tarihi 1 Nisan 2020
Kabul Tarihi 16 Mart 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 5 Sayı: 1

Kaynak Göster

Vancouver Tombul ŞT, Akdoğan B, Ergünay K, Ertoy Baydar D, Erkan İ. Ürogenital Kondilom Lezyonu Olan Erkek Hastalarda Lezyonda ve Üretral Sürüntü Örneğinde İPV Tanısı ve Tiplendirmesi. JAMER. 2020;5(1):19-24.