Dosimetric Investigation of Acetaminophen Drug Raw Materials by Electron Paramgangnetic Resonance Spectroscopy

Öz

In the present study, the active pharmaceutical ingredient Acetaminophen, which is used in the treatment of moderate pain, chemotherapy and relief of postoperative pain, was exposed to gamma radiation and the resulting paramagnetic disorder was studied by Electron Paramagnetic Resonance (EPR) spectroscopy. The suitability of the drug sample for use as a dosimetric material, radical extinction data, saturation information occurring at microwave power values and parameters related to dose-response data were investigated at room temperature. No EPR signal was observed in the sample which was not exposed to gamma radiation. Spectroscopic properties generated as a result of radiation were determined via spectrum simulation.

Anahtar Kelimeler

• Dosimetry
• Gamma Radiation
• Drug sample
• EPR
• Radicals
• Irradiated

Destekleyen Kurum

Dicle University Institute of Science and Technology.

Proje Numarası

FEN 15-001

Etik Beyan

"Science15-0001" is my research article developed with the funding of Dicle University Institute of Science and Technology and produced from my doctoral article.

Teşekkür

I would like to thank Prof. Dr. Semsettin OSMANOĞLU and Dicle University Institute of Science.

Acetaminophen İlaç Hammaddelerinin Elektron Paramanyetik Rezonans Spektroskopisi ile Dozimetrik İncelenmesi

Öz

Bu çalışmada genellikle orta seviyedeki ağrıların tedavisinde kullanılmasına rağmen ameliyat sonrası ağrıların şiddetlerinin azaltılmasında ve kanser hastalarında kemoterapi amacı ile de kullanıldığı bilinen ilaç etkin maddesi Acetaminophen toz kristalleri gama radyasyonuna maruz bırakılarak oluşan paramanyetik bozukluk Elektron Paramanyetik Rezonans (EPR) spektroskopisi ile çalışılmıştır. Örneğin dozimetrik malzeme olarak kullanıma uygunluğu, radikal sönüm bilgileri, mikrodalga güç değerlerinde doyum bilgileri ve doz-cevap eğrisi oda sıcaklığında araştırılmıştır. Gama radyasyonuna maruz bırakılmayan örnekte EPR sinyali gözlenmemiştir. Spektrum simülasyonu (benzetişimi) yapılarak radyasyon sonucunda oluşan spektroskopik özellikleri belirlenmiştir.

Anahtar Kelimeler

• Dosimetry
• Gamma Radiation
• Drug sample
• EPR
• Radicals
• Irradiated

Destekleyen Kurum

Dicle Üniversitesi Fen Bilimleri Enstitüsü.

Proje Numarası

FEN 15-001

Etik Beyan

"Fen 15-0001" Dicle Üniversitesi Fen Bilimleri Enstitüsü'nün desteğiyle geliştirilen ve doktora makalemden üretilen araştırma makalemdir.

Teşekkür

Prof. Dr. Şemsettin OSMANOĞLU'na ve Dicle Üniversitesi Fen Bilimleri Enstitüsü'ne teşekkür ediyorum.

Kaynakça

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