Araştırma Makalesi
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Acetaminophen İlaç Hammaddelerinin Elektron Paramanyetik Rezonans Spektroskopisi ile Dozimetrik İncelenmesi

Yıl 2024, , 75 - 82, 12.12.2024

Fırat Akbalık

https://doi.org/10.5281/zenodo.14344267

Öz

Bu çalışmada genellikle orta seviyedeki ağrıların tedavisinde kullanılmasına rağmen ameliyat sonrası ağrıların şiddetlerinin azaltılmasında ve kanser hastalarında kemoterapi amacı ile de kullanıldığı bilinen ilaç etkin maddesi Acetaminophen toz kristalleri gama radyasyonuna maruz bırakılarak oluşan paramanyetik bozukluk Elektron Paramanyetik Rezonans (EPR) spektroskopisi ile çalışılmıştır. Örneğin dozimetrik malzeme olarak kullanıma uygunluğu, radikal sönüm bilgileri, mikrodalga güç değerlerinde doyum bilgileri ve doz-cevap eğrisi oda sıcaklığında araştırılmıştır. Gama radyasyonuna maruz bırakılmayan örnekte EPR sinyali gözlenmemiştir. Spektrum simülasyonu (benzetişimi) yapılarak radyasyon sonucunda oluşan spektroskopik özellikleri belirlenmiştir.

Anahtar Kelimeler

Dosimetry Gamma Radiation Drug sample EPR Radicals Irradiated

Etik Beyan

"Fen 15-0001" Dicle Üniversitesi Fen Bilimleri Enstitüsü'nün desteğiyle geliştirilen ve doktora makalemden üretilen araştırma makalemdir.

Destekleyen Kurum

Dicle Üniversitesi Fen Bilimleri Enstitüsü.

Proje Numarası

FEN 15-001

Teşekkür

Prof. Dr. Şemsettin OSMANOĞLU'na ve Dicle Üniversitesi Fen Bilimleri Enstitüsü'ne teşekkür ediyorum.

Kaynakça

  • Abbar, J. C., Lamani, S. D., & Nandibewoor, S. T. (2011). Ruthenium(III) Catalyzed Oxidative Degradation of Amitriptyline-A Tricyclic Antidepressant Drug by Permanganate in Aqueous Acidic Medium. Journal of Solution Chemistry, 40(3), 502–520. https://doi.org/10.1007/s10953-011-9655-9
  • Akbalık, F. (2016). Analysis of structural defects caused by gamma radiation on some medicines through electron paramagnetic resonance and simulation techniques. PhD thesis, Dicle University.
  • Basly, J., & Bernard, M. (1997). Radio sterilization dosimetry by ESR spectroscopy: Ritodrine hydrochloride and comparison with other sympathomimetics. International Journal of Pharmaceutics, 149(1), 85–91. https://doi.org/10.1016/s0378-5173(96)04855-7
  • Basly, J., Longy, I., & Bernard, M. (1997). ESR identification of radiosterilized pharmaceuticals: latamoxef and ceftriaxone. International Journal of Pharmaceutics, 158(2), 241–245. https://doi.org/10.1016/s0378-5173(97)00257-3
  • Bhat, R., & Sridhar, K. (2011). Influence of ionizing radiation and conventional food processing treatments on the status of free radicals in lotus seeds: An ESR study. Journal of Food Composition and Analysis, 24(4–5), 563–567. https://doi.org/10.1016/j.jfca.2010.12.008
  • Damian, G. (2003). EPR investigation of γ-irradiated anti-emetic drugs. Talanta, 60(5), 923–927. https://doi.org/10.1016/s0039-9140(03)00153-x
  • Finčur, N. L., Grujić-Brojčin, M., Šćepanović, M. J., Četojević-Simin, D. D., Maletić, S. P., Stojadinović, S., & Abramović, B. F. (2021). UV-driven removal of tricyclic antidepressive drug amitriptyline using TiO2 and TiO2/WO3 coatings. Reaction Kinetics Mechanisms and Catalysis, 132(2), 1193–1209. https://doi.org/10.1007/s11144-021-01936-7
  • Ghasemi, A., & Bagheri, A. (2019). Effects of alkyl chain length on synergetic interaction and micelle formation between a homologous series of n-alkyltrimethylammonium bromides and amphiphilic drug propranolol hydrochloride. Journal of Molecular Liquids, 298, 111948. https://doi.org/10.1016/j.molliq.2019.111948
  • Gibella, M., Crucq, A., & Tilquin, B. (1993). Détection RPE de l’irradiation de médicaments. Journal De Chimie Physique, 90, 1041–1053. https://doi.org/10.1051/jcp/1993901041
  • Jeon, M., Jun, B., Kim, S., Cho, J., Park, C. M., Choong, C. E., Jang, M., & Yoon, Y. (2021). Sonodegradation of amitriptyline and ibuprofen in the presence of Ti3C2Tx MXene. Journal of Hazardous Materials Letters, 2, 100028. https://doi.org/10.1016/j.hazl.2021.100028
  • Osawa, R. A., Barrocas, B. T., Monteiro, O. C., Oliveira, M. C., & Florêncio, M. H. (2019). Visible light photocatalytic degradation of amitriptyline using cobalt doped titanate nanowires: Kinetics and characterization of transformation products. Journal of Environmental Chemical Engineering, 8(1), 103585. https://doi.org/10.1016/j.jece.2019.103585
  • Polat, M., & Korkmaz, M. (2006). Effect of radiation on solid paracetamol: ESR identification and dosimetric features of γ -irradiated paracetamol. Radiation Effects and Defects in Solids, 161(1), 51–62. https://doi.org/10.1080/10420150500467471
  • Proelss, H. F., Lohmann, H. J., & Miles, D. G. (1978). High-performance liquid-chromatographic simultaneous determination of commonly used tricyclic antidepressants. Clinical Chemistry, 24(11), 1948–1953. https://doi.org/10.1093/clinchem/24.11.1948
  • Smyth, W. F., Leslie, J. C., McClean, S., Hannigan, B., McKenna, H. P., Doherty, B., Joyce, C., & O’Kane, E. (2006). The characterisation of selected antidepressant drugs using electrospray ionisation with ion trap mass spectrometry and with quadrupole time‐of‐flight mass spectrometry and their determination by high‐performance liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 20(11), 1637–1642. https://doi.org/10.1002/rcm.2485

Dosimetric Investigation of Acetaminophen Drug Raw Materials by Electron Paramgangnetic Resonance Spectroscopy

Yıl 2024, , 75 - 82, 12.12.2024

Fırat Akbalık

https://doi.org/10.5281/zenodo.14344267

Öz

In the present study, the active pharmaceutical ingredient Acetaminophen, which is used in the treatment of moderate pain, chemotherapy and relief of postoperative pain, was exposed to gamma radiation and the resulting paramagnetic disorder was studied by Electron Paramagnetic Resonance (EPR) spectroscopy. The suitability of the drug sample for use as a dosimetric material, radical extinction data, saturation information occurring at microwave power values and parameters related to dose-response data were investigated at room temperature. No EPR signal was observed in the sample which was not exposed to gamma radiation. Spectroscopic properties generated as a result of radiation were determined via spectrum simulation.

Anahtar Kelimeler

Dosimetry Gamma Radiation Drug sample EPR Radicals Irradiated

Etik Beyan

"Science15-0001" is my research article developed with the funding of Dicle University Institute of Science and Technology and produced from my doctoral article.

Destekleyen Kurum

Dicle University Institute of Science and Technology.

Proje Numarası

FEN 15-001

Teşekkür

I would like to thank Prof. Dr. Semsettin OSMANOĞLU and Dicle University Institute of Science.

Kaynakça

  • Abbar, J. C., Lamani, S. D., & Nandibewoor, S. T. (2011). Ruthenium(III) Catalyzed Oxidative Degradation of Amitriptyline-A Tricyclic Antidepressant Drug by Permanganate in Aqueous Acidic Medium. Journal of Solution Chemistry, 40(3), 502–520. https://doi.org/10.1007/s10953-011-9655-9
  • Akbalık, F. (2016). Analysis of structural defects caused by gamma radiation on some medicines through electron paramagnetic resonance and simulation techniques. PhD thesis, Dicle University.
  • Basly, J., & Bernard, M. (1997). Radio sterilization dosimetry by ESR spectroscopy: Ritodrine hydrochloride and comparison with other sympathomimetics. International Journal of Pharmaceutics, 149(1), 85–91. https://doi.org/10.1016/s0378-5173(96)04855-7
  • Basly, J., Longy, I., & Bernard, M. (1997). ESR identification of radiosterilized pharmaceuticals: latamoxef and ceftriaxone. International Journal of Pharmaceutics, 158(2), 241–245. https://doi.org/10.1016/s0378-5173(97)00257-3
  • Bhat, R., & Sridhar, K. (2011). Influence of ionizing radiation and conventional food processing treatments on the status of free radicals in lotus seeds: An ESR study. Journal of Food Composition and Analysis, 24(4–5), 563–567. https://doi.org/10.1016/j.jfca.2010.12.008
  • Damian, G. (2003). EPR investigation of γ-irradiated anti-emetic drugs. Talanta, 60(5), 923–927. https://doi.org/10.1016/s0039-9140(03)00153-x
  • Finčur, N. L., Grujić-Brojčin, M., Šćepanović, M. J., Četojević-Simin, D. D., Maletić, S. P., Stojadinović, S., & Abramović, B. F. (2021). UV-driven removal of tricyclic antidepressive drug amitriptyline using TiO2 and TiO2/WO3 coatings. Reaction Kinetics Mechanisms and Catalysis, 132(2), 1193–1209. https://doi.org/10.1007/s11144-021-01936-7
  • Ghasemi, A., & Bagheri, A. (2019). Effects of alkyl chain length on synergetic interaction and micelle formation between a homologous series of n-alkyltrimethylammonium bromides and amphiphilic drug propranolol hydrochloride. Journal of Molecular Liquids, 298, 111948. https://doi.org/10.1016/j.molliq.2019.111948
  • Gibella, M., Crucq, A., & Tilquin, B. (1993). Détection RPE de l’irradiation de médicaments. Journal De Chimie Physique, 90, 1041–1053. https://doi.org/10.1051/jcp/1993901041
  • Jeon, M., Jun, B., Kim, S., Cho, J., Park, C. M., Choong, C. E., Jang, M., & Yoon, Y. (2021). Sonodegradation of amitriptyline and ibuprofen in the presence of Ti3C2Tx MXene. Journal of Hazardous Materials Letters, 2, 100028. https://doi.org/10.1016/j.hazl.2021.100028
  • Osawa, R. A., Barrocas, B. T., Monteiro, O. C., Oliveira, M. C., & Florêncio, M. H. (2019). Visible light photocatalytic degradation of amitriptyline using cobalt doped titanate nanowires: Kinetics and characterization of transformation products. Journal of Environmental Chemical Engineering, 8(1), 103585. https://doi.org/10.1016/j.jece.2019.103585
  • Polat, M., & Korkmaz, M. (2006). Effect of radiation on solid paracetamol: ESR identification and dosimetric features of γ -irradiated paracetamol. Radiation Effects and Defects in Solids, 161(1), 51–62. https://doi.org/10.1080/10420150500467471
  • Proelss, H. F., Lohmann, H. J., & Miles, D. G. (1978). High-performance liquid-chromatographic simultaneous determination of commonly used tricyclic antidepressants. Clinical Chemistry, 24(11), 1948–1953. https://doi.org/10.1093/clinchem/24.11.1948
  • Smyth, W. F., Leslie, J. C., McClean, S., Hannigan, B., McKenna, H. P., Doherty, B., Joyce, C., & O’Kane, E. (2006). The characterisation of selected antidepressant drugs using electrospray ionisation with ion trap mass spectrometry and with quadrupole time‐of‐flight mass spectrometry and their determination by high‐performance liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 20(11), 1637–1642. https://doi.org/10.1002/rcm.2485
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Doğrusal Olmayan Optik ve Spektroskopi
Bölüm Araştırma Makaleleri
Yazarlar

Fırat Akbalık 0000-0002-7506-379X

Proje Numarası FEN 15-001
Erken Görünüm Tarihi 10 Aralık 2024
Yayımlanma Tarihi 12 Aralık 2024
Gönderilme Tarihi 27 Haziran 2024
Kabul Tarihi 18 Kasım 2024
Yayımlandığı Sayı Yıl 2024

Kaynak Göster

APA Akbalık, F. (2024). Dosimetric Investigation of Acetaminophen Drug Raw Materials by Electron Paramgangnetic Resonance Spectroscopy. Journal of Anatolian Physics and Astronomy, 3(2), 75-82. https://doi.org/10.5281/zenodo.14344267