BibTex RIS Kaynak Göster

The relationship between level of anti-CCP, clinical activity and quality of life in patients with psoriatic arthritis

Yıl 2011, , 187 - 191, 01.06.2011
https://doi.org/10.5799/ahinjs.01.2011.02.0236

Öz

Objectives: Psoriatic arthritis (PsA) is an inflammatory joint disease. The aim of this study was to investigate the titers of Anti-syclic citrullinated protein (anti-CCP antibodies) in PsA and assess their associations with clinical characteristics and quality of life. Materials and methods: Fourty two patients with PsA and 38 healthy control subjects were included. Demographic data and clinical characteristics including age, gender, disease duration, and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-CCP antibodies and rheumatoid factor were assessed. Visual analog scale (VAS), Nottingham Health Profile (NHP) and short form-36 (SF-36) were used to evaluate QOL in both groups. Results: The demographic data of the subjects were not different between the groups. Patients with PsA had higher anti-CCP levels compared to healthy controls (56.3±73.0 U vs. 0.9±0.5 U, respectively, p=0.01) Thirteen (33.3%) patients with PsA had positive anti-CCP, while no anti-CCP positivity was found in the control group (p

Kaynakça

  • Salaffi F, Carotti M, Gasparini S, Intorcia M, Grassi W. The health-related quality of life in rheumatoid arthritis, ankylo- sing spondylitis, and psoriatic arthritis: a comparison with a selected sample of healthy people. Health Qual Life Out- comes 2009;7(1):25-9.
  • Schellekens GA, Visser H, de Jong BA, et al. The diag- nostic properties of rheumatoid arthritis antibodies rec- ognizing a cyclic citrullinated peptide. Arthritis Rheum 2000;43(1):155-63.
  • Bogliolo L, Alpini C, Caporali R, Scire CA, Moratti R, Mon- tecucco C. Antibodies to cyclic citrullinated peptides in psoriatic arthritis. J Rheumatol 2005;32(3):511-5.
  • Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H. Classification criteria for psoriatic arthritis: de- velopment of new criteria from a large international study. Arthritis Rheum 2006;54(8):2665-73.
  • Goldbach-Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen JS, et al. Rheumatoid arthritis associated autoan- tibodies in patients with synovitis of recent onset. Arthritis Res 2000;2(3):236-43.
  • Korendowych E, Owen P, Ravindran J, Carmichael C, McHugh N. The clinical and genetic associations of anti- cyclic citrullinated peptide antibodies in psoriatic arthritis. Rheumatology (Oxford) 2005;44(8):1056-60.
  • Torre Alonso JC, Rodriguez Perez A, Arribas Castrillo JM, Ballina Garcia J, Riestra Noriega JL, Lopez Larrea C. Pso- riatic arthritis (PA): a clinical, immunological and radiolog- ical study of 180 patients. Br J Rheumatol 1991;30(4):245- 50.
  • Abdel Fattah NS, Hassan HE, Galal ZA, El Okda el SE. As- sessment of anti-cyclic citrullinated peptide in psoriatic ar- thritis. BMC Res Notes 2009;2(1):44-5.
  • Alenius GM, Jidell E, Nordmark L, Rantapaa Dahlqvist S. Disease manifestations and HLA antigens in psoriatic ar- thritis in northern Sweden. Clin Rheumatol 2002;21(5):357- 62.
  • Zink A, Thiele K, Huscher D, et al. Healthcare and burden of disease in psoriatic arthritis. A comparison with rheu- matoid arthritis and ankylosing spondylitis. J Rheumatol 2006;33(1):86-90.
  • Sokoll KB, Helliwell PS. Comparison of disability and quality of life in rheumatoid and psoriatic arthritis. J Rheu- matol 2001;28(8):1842-6.
  • Borman P, Toy GG, Babaoglu S, Bodur H, Ciliz D, Alli N. A comparative evaluation of quality of life and life satisfac- tion in patients with psoriatic and rheumatoid arthritis. Clin Rheumatol 2007;26(3):330-4.
  • Husted JA, Gladman DD, Farewell VT, Cook RJ. Health- related quality of life of patients with psoriatic arthritis: a comparison with patients with rheumatoid arthritis. Arthri- tis Rheum 2001;45(2):151-8.
  • Husted JA, Tom BD, Schentag CT, Farewell VT, Gladman DD. Occurrence and correlates of fatigue in psoriatic arthri- tis. Ann Rheum Dis 2009;68(10):1553-8.
  • Gladman DD, Mease PJ, Krueger G, van der Heidje DM, Antoni C, Helliwell PS, et al. Outcome measures in psori- atic arthritis. J Rheumatol 2005;32(11):2262-9.
  • Alenius GM, Berglin E, Rantapaa Dahlqvist S. Antibodies against cyclic citrullinated peptide (CCP) in psoriatic pa- tients with or without joint inflammation. Ann Rheum Dis 2006;65(3):398-400.
  • Candia L, Marquez J, Gonzalez C, et al. Low frequency of anticyclic citrullinated peptide antibodies in psoriatic arthritis but not in cutaneous psoriasis. J Clin Rheumatol 2006;12(5):226-9.
  • Inanc N, Dalkilic E, Kamali S, et al. Anti-CCP antibodies in rheumatoid arthritis and psoriatic arthritis. Clin Rheumatol 2007;26(1):17-23.
  • Setty AR, Curhan G, Choi HK. Smoking and the risk of psoriasis in women: Nurses’ Health Study II. Am J Med 2007;120(11):953-9.
  • Vander Cruyssen B, Hoffman IE, Zmierczak H, Van den Berghe M, Kruithof E, De Rycke L, et al. Anti-citrullinated peptide antibodies may occur in patients with psoriatic ar- thritis. Ann Rheum Dis 2005;64(8):1145-9.

Psoriatik artritli hastalarda anti-CCP düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişki

Yıl 2011, , 187 - 191, 01.06.2011
https://doi.org/10.5799/ahinjs.01.2011.02.0236

Öz

Amaç: Psoriatik artrit (PsA); psoriasis ile ilişkili bir kronik inflamatuar eklem hastalığıdır. Bu çalışmada PsA'lı hastalarda Anti-siklik sitrülenmiş protein (anti-CCP) düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve yöntem: Çalışmaya 42 PsA hastası çalışma grubu ve 38 sağlıklı birey kontrol grubu olarak alındı. Demografik ve klinik özellikler; yaş, cinsiyet, hastalık süresi, Eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP), anti-CCP antikorları, RF ve vizual ağrı skalası (VAS) ile periferik eklem ağrısı değerlendirildi. Nottingham Sağlık Profili (NHP) ve Short form-36 (SF-36) her iki grupta yaşam kalitesini değerlendirmek için kullanıldı. Bulgular: Gruplar arasındaki demografik özellikler farklı değildi. Anti-CCP antikor düzeyleri PsA hastalarında (56.3±73.0 Ünite) kontrol grubuyla (0.9±0.5 Ünite) karşılaştırıldığında anlamlı yüksek bulundu (p=0.01). Anti-CCP antikoru pozitif birey sayısı PsA'li hasta grubunda kontrol grubuna göre anlamlı olarak yüksekti (%33.3 hastaya karşılık %0) (p

Kaynakça

  • Salaffi F, Carotti M, Gasparini S, Intorcia M, Grassi W. The health-related quality of life in rheumatoid arthritis, ankylo- sing spondylitis, and psoriatic arthritis: a comparison with a selected sample of healthy people. Health Qual Life Out- comes 2009;7(1):25-9.
  • Schellekens GA, Visser H, de Jong BA, et al. The diag- nostic properties of rheumatoid arthritis antibodies rec- ognizing a cyclic citrullinated peptide. Arthritis Rheum 2000;43(1):155-63.
  • Bogliolo L, Alpini C, Caporali R, Scire CA, Moratti R, Mon- tecucco C. Antibodies to cyclic citrullinated peptides in psoriatic arthritis. J Rheumatol 2005;32(3):511-5.
  • Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H. Classification criteria for psoriatic arthritis: de- velopment of new criteria from a large international study. Arthritis Rheum 2006;54(8):2665-73.
  • Goldbach-Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen JS, et al. Rheumatoid arthritis associated autoan- tibodies in patients with synovitis of recent onset. Arthritis Res 2000;2(3):236-43.
  • Korendowych E, Owen P, Ravindran J, Carmichael C, McHugh N. The clinical and genetic associations of anti- cyclic citrullinated peptide antibodies in psoriatic arthritis. Rheumatology (Oxford) 2005;44(8):1056-60.
  • Torre Alonso JC, Rodriguez Perez A, Arribas Castrillo JM, Ballina Garcia J, Riestra Noriega JL, Lopez Larrea C. Pso- riatic arthritis (PA): a clinical, immunological and radiolog- ical study of 180 patients. Br J Rheumatol 1991;30(4):245- 50.
  • Abdel Fattah NS, Hassan HE, Galal ZA, El Okda el SE. As- sessment of anti-cyclic citrullinated peptide in psoriatic ar- thritis. BMC Res Notes 2009;2(1):44-5.
  • Alenius GM, Jidell E, Nordmark L, Rantapaa Dahlqvist S. Disease manifestations and HLA antigens in psoriatic ar- thritis in northern Sweden. Clin Rheumatol 2002;21(5):357- 62.
  • Zink A, Thiele K, Huscher D, et al. Healthcare and burden of disease in psoriatic arthritis. A comparison with rheu- matoid arthritis and ankylosing spondylitis. J Rheumatol 2006;33(1):86-90.
  • Sokoll KB, Helliwell PS. Comparison of disability and quality of life in rheumatoid and psoriatic arthritis. J Rheu- matol 2001;28(8):1842-6.
  • Borman P, Toy GG, Babaoglu S, Bodur H, Ciliz D, Alli N. A comparative evaluation of quality of life and life satisfac- tion in patients with psoriatic and rheumatoid arthritis. Clin Rheumatol 2007;26(3):330-4.
  • Husted JA, Gladman DD, Farewell VT, Cook RJ. Health- related quality of life of patients with psoriatic arthritis: a comparison with patients with rheumatoid arthritis. Arthri- tis Rheum 2001;45(2):151-8.
  • Husted JA, Tom BD, Schentag CT, Farewell VT, Gladman DD. Occurrence and correlates of fatigue in psoriatic arthri- tis. Ann Rheum Dis 2009;68(10):1553-8.
  • Gladman DD, Mease PJ, Krueger G, van der Heidje DM, Antoni C, Helliwell PS, et al. Outcome measures in psori- atic arthritis. J Rheumatol 2005;32(11):2262-9.
  • Alenius GM, Berglin E, Rantapaa Dahlqvist S. Antibodies against cyclic citrullinated peptide (CCP) in psoriatic pa- tients with or without joint inflammation. Ann Rheum Dis 2006;65(3):398-400.
  • Candia L, Marquez J, Gonzalez C, et al. Low frequency of anticyclic citrullinated peptide antibodies in psoriatic arthritis but not in cutaneous psoriasis. J Clin Rheumatol 2006;12(5):226-9.
  • Inanc N, Dalkilic E, Kamali S, et al. Anti-CCP antibodies in rheumatoid arthritis and psoriatic arthritis. Clin Rheumatol 2007;26(1):17-23.
  • Setty AR, Curhan G, Choi HK. Smoking and the risk of psoriasis in women: Nurses’ Health Study II. Am J Med 2007;120(11):953-9.
  • Vander Cruyssen B, Hoffman IE, Zmierczak H, Van den Berghe M, Kruithof E, De Rycke L, et al. Anti-citrullinated peptide antibodies may occur in patients with psoriatic ar- thritis. Ann Rheum Dis 2005;64(8):1145-9.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Yazısı
Yazarlar

Remziye Akçalı Bu kişi benim

Mehtap Bozkurt Bu kişi benim

Kemal Nas Bu kişi benim

İbrahim Yardımeden Bu kişi benim

Demet Uçar Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2011
Yayımlandığı Sayı Yıl 2011

Kaynak Göster

APA Akçalı, R., Bozkurt, M., Nas, K., Yardımeden, İ., vd. (2011). Psoriatik artritli hastalarda anti-CCP düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişki. Journal of Clinical and Experimental Investigations, 2(2), 187-191. https://doi.org/10.5799/ahinjs.01.2011.02.0236
AMA Akçalı R, Bozkurt M, Nas K, Yardımeden İ, Uçar D. Psoriatik artritli hastalarda anti-CCP düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişki. J Clin Exp Invest. Haziran 2011;2(2):187-191. doi:10.5799/ahinjs.01.2011.02.0236
Chicago Akçalı, Remziye, Mehtap Bozkurt, Kemal Nas, İbrahim Yardımeden, ve Demet Uçar. “Psoriatik Artritli Hastalarda Anti-CCP düzeyi Ile Klinik Aktivite Ve yaşam Kalitesi arasındaki ilişki”. Journal of Clinical and Experimental Investigations 2, sy. 2 (Haziran 2011): 187-91. https://doi.org/10.5799/ahinjs.01.2011.02.0236.
EndNote Akçalı R, Bozkurt M, Nas K, Yardımeden İ, Uçar D (01 Haziran 2011) Psoriatik artritli hastalarda anti-CCP düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişki. Journal of Clinical and Experimental Investigations 2 2 187–191.
IEEE R. Akçalı, M. Bozkurt, K. Nas, İ. Yardımeden, ve D. Uçar, “Psoriatik artritli hastalarda anti-CCP düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişki”, J Clin Exp Invest, c. 2, sy. 2, ss. 187–191, 2011, doi: 10.5799/ahinjs.01.2011.02.0236.
ISNAD Akçalı, Remziye vd. “Psoriatik Artritli Hastalarda Anti-CCP düzeyi Ile Klinik Aktivite Ve yaşam Kalitesi arasındaki ilişki”. Journal of Clinical and Experimental Investigations 2/2 (Haziran 2011), 187-191. https://doi.org/10.5799/ahinjs.01.2011.02.0236.
JAMA Akçalı R, Bozkurt M, Nas K, Yardımeden İ, Uçar D. Psoriatik artritli hastalarda anti-CCP düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişki. J Clin Exp Invest. 2011;2:187–191.
MLA Akçalı, Remziye vd. “Psoriatik Artritli Hastalarda Anti-CCP düzeyi Ile Klinik Aktivite Ve yaşam Kalitesi arasındaki ilişki”. Journal of Clinical and Experimental Investigations, c. 2, sy. 2, 2011, ss. 187-91, doi:10.5799/ahinjs.01.2011.02.0236.
Vancouver Akçalı R, Bozkurt M, Nas K, Yardımeden İ, Uçar D. Psoriatik artritli hastalarda anti-CCP düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişki. J Clin Exp Invest. 2011;2(2):187-91.