BibTex RIS Kaynak Göster

Models of experimental epilepsy

Yıl 2011, , 118 - 123, 01.03.2011
https://doi.org/10.5799/ahinjs.01.2011.01.0224

Öz

Epilepsy is the most common serious neurological condition in the world, with an estimated prevalence of 1% of the population. A large number of experimental models of seizure and epilepsy have been developed. These experimental models are elicited by chemical convulsants, electrical stimulation, genetic models, structural lesions, physical stimuli (cold, pressure, hyperthermia, electrical) in animals. Well-characterized animal models may allow the understanding of the basic mechanisms underlying epileptogenesis (it refers to the alteration of a normal neuronal network into a hyperexcitable network in which recurrent, spontaneous seizures occur). Moreover, these models might also prove useful in identifying novel therapeutic approaches to treatment of epilepsy.

Kaynakça

  • Seino M. Classification criteria of epileptic seizures and syndromes. Epilepsy Res 2006;70(Suppl 1):27-33.
  • Zupec-Kania BA, Spellman E. An overview of the keto- genic diet for pediatric epilepsy. Nutr Clin Pract 2009;23:589-596.
  • Bertram EH. Temporal lobe epilepsy: where do the seizures really begin? Epilepsy Behav 2009;14(Suppl 1):32-37.
  • Cloix JF, Hévor T. Epilepsy, regulation of brain energy me- tabolism and neurotransmission. Curr Med Chem 2009;16:841-853.
  • Lehnertz K, Bialonski S, Horstmann MT, et al. Synchroni- zation phenomena in human epileptic brain networks. J Neurosci Methods 2009;183:42-48.
  • Artieda J, Alegre M, Valencia M, et al. Brain oscillations: pathophysiological and potentially therapeutic role in some neurological and psychiatric diseases. An Sist Sanit Navar 2009;32(Suppl 3):45-60.
  • Postnova S, Finke C, Jin W, Schneider H, Braun HA. A computational study of the interdependencies between neuronal impulse pattern, noise effects and synchroniza- tion. J Physiol Paris 2010;104:176-189.
  • Altay EE, Bilir E. Demans ve epilepsi. Demans Dizisi 1999;4:116-128.
  • Commission on Classification and Terminology of the In- ternational League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epi- lepsia 1989;30:389–399.
  • Garcia Garcia ME, Garcia Morales I, Matías Guiu J. Ex- perimental models in epilepsy. Neurologia 2010;25:181-8.
  • Galanopoulou AS, Moshé SL. The epileptic hypothesis: developmentally related arguments based on animal mod- els. Epilepsia 2009;50(Suppl 7):37-42.
  • Engel JJ, Schwartzkroin PA. What Should Be Modeled? In: Pitkanen A, Schwartzkroin PA, Moshe SL, (eds): Models of Seizures and Epilepsy. San Diego, Elsevier Academic Press, 2006;1-14.
  • Contreras D. Experimental models in epilepsy. Elsevier Academic Press, 2000;30:370-376. Revista de Neurologia
  • Fisher RS. Animal models of the epilepsies. Brain Res Brain Res Rev 1989;14:245-278.
  • McCandless DW, FineSmith RB. Chemically induced models of seizures. Animal Models of Neurological Dis- ease, II Metabolic Encephalopathies and the Epilepsies. 1992: Vol 22.
  • Sarkisian MR. Overview of the current animal models for human seizure and epileptic disorders. Epilepsy Behavior 2001;2:201–216.
  • Onat F. Epilepsinin deneysel modelleri. Epilepsi. Nobel Tıp Kitabevleri 2008;4:37-43.
  • Coppola G, Arcieri S, D’Aniello A, et al. Levetiracetam in submaximal subcutaneous pentylentetrazol-induced sei- zures in rats. Seizure 2010;19:296-299.
  • Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog Neurobiol 1998;55:27- 57.
  • Manning JP, Richards DA, Bowery NG. Pharmacology of absence epilepsy. Trends Pharmacol Sci 2003;24:542-549.
  • Morimoto K, Fahnestock M, Racine RJ. Kindling and sta- tus epilepticus models of epilepsy: rewiring the brain. Prog Neurobiol 2004;73:1-60.
  • Bethmann K, Fritschy JM, Brandt C, Löscher W. Antiepi- leptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of tempo- ral lobe epilepsy. Neurobiol Dis 2008;31:169-187.
  • Majores M, Eils J, Wiestler OD, Becker AJ. Molecular profiling of temporal lobe epilepsy: comparison of data from human tissue samples and animal models. Epilepsy Res 2004;60:173-178.
  • Goddard GV, McIntyre DC, Leech CK. A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 1969;25:295–330.
  • Bertram E. The relevance of kindling for human epilepsy. Epilepsia 2007;48(Suppl 2):65–74.
  • Nolte MW, Löscher W, Herden C, Freed WJ, Gernert M. Benefits and risks of intranigral transplantation of GABA- producing cells subsequent to the establishment of kin- dling-induced seizures. Neurobiol Dis 2008;31:342-354.
  • Kalynchuk LE, Pinel JP, Meaney MJ. Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled rats. Neurosci Lett 2006;396:38- 43.
  • Carçak N, Ferrandon A, Koning E, et al. Effect of stage 2 kindling on local cerebral blood flow rates in rats with ge- netic absence epilepsy. Epilepsia 2009;50:33-43.
  • Engel J, Pedley TA, Aicardi J, Dichter MA. Epilepsy: A Comprehensive Textbook. Second edition.Volume one. Lippincott Williams & Wilkins, USA 2008.
  • Karabekiroğlu K. Antenatal dönemde steroidlerin fötal beyin üzerine etkileri ve psikiyatrik sonuçları. Yeni Sem- pozyum 2007;45-56.
  • Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972;32;281–294.
  • Post RM. Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms? Epi- lepsy Res 2002;50:203-219.
  • Pitkänen A, Schwartzkroin PA, Moshé SL, (Eds). Models of seizures and epilepsy. Elsevier Academic Press 2006:345-350.

Models of experimental epilepsy

Yıl 2011, , 118 - 123, 01.03.2011
https://doi.org/10.5799/ahinjs.01.2011.01.0224

Öz

Epilepsi, % 1 prevelansa sahip olduğu tahmin edilen, dünyada en yaygın görülen ciddi nörololojik durumdur. Birçok sayıda, deneysel epilepsi ve nöbet modeli geliştirilmiştir. Bu deneysel modeller hayvanlarda elektrik uyarımı, kimyasal konvülsanlar, genetik modeller, yapısal lezyonlar, fiziksel uyaranlar (soğuk, basınç, hipertermi, elektriksel) ile oluşturulmaktadır. İyi karakterize edilmiş hayvan modelleri epileptogenezisin (normal nöronal bir ağın spontan, hipereksitabilite ağına değişmesi) altında yatan temel mekanizmaların anlaşılmasına olanak sağlayabilmektedir. Üstelik bu modeller epilepsi tedavisinde yeni tedavi edici yaklaşımların belirlenmesinde de yararlı olabilmektedir. Klin Den Ar Derg 2011; 2(1): 118-123

Kaynakça

  • Seino M. Classification criteria of epileptic seizures and syndromes. Epilepsy Res 2006;70(Suppl 1):27-33.
  • Zupec-Kania BA, Spellman E. An overview of the keto- genic diet for pediatric epilepsy. Nutr Clin Pract 2009;23:589-596.
  • Bertram EH. Temporal lobe epilepsy: where do the seizures really begin? Epilepsy Behav 2009;14(Suppl 1):32-37.
  • Cloix JF, Hévor T. Epilepsy, regulation of brain energy me- tabolism and neurotransmission. Curr Med Chem 2009;16:841-853.
  • Lehnertz K, Bialonski S, Horstmann MT, et al. Synchroni- zation phenomena in human epileptic brain networks. J Neurosci Methods 2009;183:42-48.
  • Artieda J, Alegre M, Valencia M, et al. Brain oscillations: pathophysiological and potentially therapeutic role in some neurological and psychiatric diseases. An Sist Sanit Navar 2009;32(Suppl 3):45-60.
  • Postnova S, Finke C, Jin W, Schneider H, Braun HA. A computational study of the interdependencies between neuronal impulse pattern, noise effects and synchroniza- tion. J Physiol Paris 2010;104:176-189.
  • Altay EE, Bilir E. Demans ve epilepsi. Demans Dizisi 1999;4:116-128.
  • Commission on Classification and Terminology of the In- ternational League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epi- lepsia 1989;30:389–399.
  • Garcia Garcia ME, Garcia Morales I, Matías Guiu J. Ex- perimental models in epilepsy. Neurologia 2010;25:181-8.
  • Galanopoulou AS, Moshé SL. The epileptic hypothesis: developmentally related arguments based on animal mod- els. Epilepsia 2009;50(Suppl 7):37-42.
  • Engel JJ, Schwartzkroin PA. What Should Be Modeled? In: Pitkanen A, Schwartzkroin PA, Moshe SL, (eds): Models of Seizures and Epilepsy. San Diego, Elsevier Academic Press, 2006;1-14.
  • Contreras D. Experimental models in epilepsy. Elsevier Academic Press, 2000;30:370-376. Revista de Neurologia
  • Fisher RS. Animal models of the epilepsies. Brain Res Brain Res Rev 1989;14:245-278.
  • McCandless DW, FineSmith RB. Chemically induced models of seizures. Animal Models of Neurological Dis- ease, II Metabolic Encephalopathies and the Epilepsies. 1992: Vol 22.
  • Sarkisian MR. Overview of the current animal models for human seizure and epileptic disorders. Epilepsy Behavior 2001;2:201–216.
  • Onat F. Epilepsinin deneysel modelleri. Epilepsi. Nobel Tıp Kitabevleri 2008;4:37-43.
  • Coppola G, Arcieri S, D’Aniello A, et al. Levetiracetam in submaximal subcutaneous pentylentetrazol-induced sei- zures in rats. Seizure 2010;19:296-299.
  • Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog Neurobiol 1998;55:27- 57.
  • Manning JP, Richards DA, Bowery NG. Pharmacology of absence epilepsy. Trends Pharmacol Sci 2003;24:542-549.
  • Morimoto K, Fahnestock M, Racine RJ. Kindling and sta- tus epilepticus models of epilepsy: rewiring the brain. Prog Neurobiol 2004;73:1-60.
  • Bethmann K, Fritschy JM, Brandt C, Löscher W. Antiepi- leptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of tempo- ral lobe epilepsy. Neurobiol Dis 2008;31:169-187.
  • Majores M, Eils J, Wiestler OD, Becker AJ. Molecular profiling of temporal lobe epilepsy: comparison of data from human tissue samples and animal models. Epilepsy Res 2004;60:173-178.
  • Goddard GV, McIntyre DC, Leech CK. A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 1969;25:295–330.
  • Bertram E. The relevance of kindling for human epilepsy. Epilepsia 2007;48(Suppl 2):65–74.
  • Nolte MW, Löscher W, Herden C, Freed WJ, Gernert M. Benefits and risks of intranigral transplantation of GABA- producing cells subsequent to the establishment of kin- dling-induced seizures. Neurobiol Dis 2008;31:342-354.
  • Kalynchuk LE, Pinel JP, Meaney MJ. Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled rats. Neurosci Lett 2006;396:38- 43.
  • Carçak N, Ferrandon A, Koning E, et al. Effect of stage 2 kindling on local cerebral blood flow rates in rats with ge- netic absence epilepsy. Epilepsia 2009;50:33-43.
  • Engel J, Pedley TA, Aicardi J, Dichter MA. Epilepsy: A Comprehensive Textbook. Second edition.Volume one. Lippincott Williams & Wilkins, USA 2008.
  • Karabekiroğlu K. Antenatal dönemde steroidlerin fötal beyin üzerine etkileri ve psikiyatrik sonuçları. Yeni Sem- pozyum 2007;45-56.
  • Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972;32;281–294.
  • Post RM. Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms? Epi- lepsy Res 2002;50:203-219.
  • Pitkänen A, Schwartzkroin PA, Moshé SL, (Eds). Models of seizures and epilepsy. Elsevier Academic Press 2006:345-350.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derleme
Yazarlar

Gönül Bambal Bu kişi benim

Duygu Çakıl Bu kişi benim

Fatih Ekici Bu kişi benim

Yayımlanma Tarihi 1 Mart 2011
Yayımlandığı Sayı Yıl 2011

Kaynak Göster

APA Bambal, G., Çakıl, D., & Ekici, F. (2011). Models of experimental epilepsy. Journal of Clinical and Experimental Investigations, 2(1), 118-123. https://doi.org/10.5799/ahinjs.01.2011.01.0224
AMA Bambal G, Çakıl D, Ekici F. Models of experimental epilepsy. J Clin Exp Invest. Mart 2011;2(1):118-123. doi:10.5799/ahinjs.01.2011.01.0224
Chicago Bambal, Gönül, Duygu Çakıl, ve Fatih Ekici. “Models of Experimental Epilepsy”. Journal of Clinical and Experimental Investigations 2, sy. 1 (Mart 2011): 118-23. https://doi.org/10.5799/ahinjs.01.2011.01.0224.
EndNote Bambal G, Çakıl D, Ekici F (01 Mart 2011) Models of experimental epilepsy. Journal of Clinical and Experimental Investigations 2 1 118–123.
IEEE G. Bambal, D. Çakıl, ve F. Ekici, “Models of experimental epilepsy”, J Clin Exp Invest, c. 2, sy. 1, ss. 118–123, 2011, doi: 10.5799/ahinjs.01.2011.01.0224.
ISNAD Bambal, Gönül vd. “Models of Experimental Epilepsy”. Journal of Clinical and Experimental Investigations 2/1 (Mart 2011), 118-123. https://doi.org/10.5799/ahinjs.01.2011.01.0224.
JAMA Bambal G, Çakıl D, Ekici F. Models of experimental epilepsy. J Clin Exp Invest. 2011;2:118–123.
MLA Bambal, Gönül vd. “Models of Experimental Epilepsy”. Journal of Clinical and Experimental Investigations, c. 2, sy. 1, 2011, ss. 118-23, doi:10.5799/ahinjs.01.2011.01.0224.
Vancouver Bambal G, Çakıl D, Ekici F. Models of experimental epilepsy. J Clin Exp Invest. 2011;2(1):118-23.