Coexistance of JAK2V617F mutation and BCR/ABL translocation in one patient

Yıl 2010, , 138 - 140, 01.06.2010

Osman Yokuş Fatih Kurnaz Özlem Şahin Balçık Burak Uz Murat Albayrak

https://doi.org/10.5799/ahinjs.01.2010.02.0029

Öz

Anahtar Kelimeler

JAK2V617F mutasyonu, BCR/ABL translokasyonu, miyeloproliferatif bozukluklar, miyelofibroz

Coexistance of JAK2V617F mutation and BCR/ABL translocation in one patient

Öz

liland DG. Expression of Jak2V617F causes a polycthemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 2006;107:4274–81. 4. Jelinek J, Oki Y, Gharibyan V et al. JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Phil- adelphia chromosome-negative CML, and megakaryocytic leukemia. Blood 2005;106:3370–3

Anahtar Kelimeler

JAK2V617F mutation, BCR/ABL translocation, miyeloproliferative disorders, myelofibrosis

Kaynakça

• Tefferi A. Classification, diagnosis and management of myeloproliferative disorders in the JAK2V617F era. Hematology Am Soc Hematol Educ Program 2006;240–5.
• James C, Ugo V, Le Couedic JP et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005;434:1144–8.
• Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG. Expression of Jak2V617F causes a polycthemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 2006;107:4274–81.
• Jelinek J, Oki Y, Gharibyan V et al. JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood 2005;106:3370–3.
• Bock O, Büsche G, Koop C, Schröter S, Buhr T, Kreipe H. Detection of the single hotspot mutation in the JH2 pseudokinase domain of janus kinase 2 in bone marrow trephine biopsies derived from chronic myeloproliferative disorders. Journal of Molecular Diagnostics 2006; 8:170-7.
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