BibTex RIS Kaynak Göster

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Yıl 2015, , 40 - 43, 10.05.2015
https://doi.org/10.5799/ahinjs.01.2015.01.0483

Öz

Objective: It was aimed to investigate the neutrophil, eosinophil, lymphocyte, platelet count, neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with vernal keratoconjunctivitis (VKC).Methods: The medical records of the VKC patients who admitted to ophthalmology polyclinic were evaluated. Age and sex matched control group was consisted with patients without any systemic or ocular disease except strabismus. Age and gender of all participants were recorded. Hemogram parameters such as mean platelet volume (MPV), neutrophil, eosinophil, lymphocyte, platelet count, NLR were measured by automatized analyzer. Data were compared between the groups.Results: Thirty patients and 30 control subjects were studied. There were no significant differences with respect to age and gender between groups. The mean MPV and NLR values were higher but not statistically significant in VKC group compared to control group (p=0.19, p=0.16, respectively). Conclusion: The results of the current study demonstrated that MPV and NLR values were not associated with VKC. Higher MPV and NLR results in patients with VKC although the differences were not reach statistically significances may suggest that MPV and NLR may be auxiliary parameter. J Clin Exp Invest 2015; 6 (1): 40-43

Kaynakça

  • Kanski JJ. Clinical ophthalmology. A systematic approach
  • nd ed Boston, Massachusetts: ButterworthHeinemann
  • ;629.
  • El-Asrar A.A, Al-Mansouri S, Tabbara K, et al. Immunopathogenesis
  • of conjunctival remodeling in vernal
  • keratoconjunctivitis. Eye 2005;20:71-79.
  • Bonini S, Bonini S, Lambiase A, et al. Vernal keratoconjunctivitis
  • revisited: a case series of 195 patients with
  • long-term follow up. Ophthalmology 2000;107:1157-
  • -
  • Kosrirukvongs P, Vichyanond P, Wongsawad W. Vernal
  • keratoconjunctivitis in Thailand. Asian Pac J Allergy
  • Immunol 2003;21:25-30.
  • Şahin A, Şahin M, Yüksel H, et al. The mean platelet
  • volume in patients with retinal vein occlusion. J Ophthalmol
  • ;236371.
  • Çil H, Yavuz C, İslamoğlu Y, et al. Platelet count and
  • mean platelet volume in patients with in-hospital
  • deep venous thrombosis. Clin Appl Thromb Hemost
  • ;18:650-653.
  • Giles H, Smith R, Martin J. Platelet glycoprotein IIb-IIIa
  • and size are increased in acute myocardial infarction.
  • Eur J Clin Invest. 1994;24:69-72.
  • Alkhouri N, Morris SG, Campbell C, et al. Neutrophil
  • to lymphocyte ratio: a new marker for predicting steatohepatitis
  • and fibrosis in patients with nonalcoholic
  • fatty liver disease. Liver Int 2012;32:297-302.
  • Cho SY, Lee A, Lee HJ, et al. Mean platelet volume
  • in Korean patients with hepatic diseases. Platelets
  • ;23:648-649.
  • Arikanoglu A, Yucel Y, Acar A, et al. The relationship of
  • the mean platelet volume and C-reactive protein levels
  • with mortality in ischemic stroke patients. Eur Rev
  • Med Pharmacol Sci 2013;17:1774-1777.
  • Celik T, Kaya M.G, Akpek M, et al, Predictive value
  • of admission platelet volume indices for in-hospital
  • major adverse cardiovascular events in acute STsegment
  • elevation myocardial infarction. Angiology
  • ;66:155-162
  • Ranjith M, Divya R, Mehta V, et al. Significance of
  • platelet volume indices and platelet count in ischaemic
  • heart disease. J Clin Pathol 2009;62:830-833.
  • Hourani S, Cusack N. Pharmacological receptors on
  • blood platelets. Pharmacol Rev 1991;43:243-298.
  • Baudouin C, Liang H, Bremond G.D, et al. CCR4 and
  • CCR5 expression in conjunctival specimens as differential
  • markers of T< sub> H</sub> 1/T< sub> H</
  • sub> 2 in ocular surface disorders. J Allergy Clin Immunol
  • ;116:614-619.
  • Aragona P, Romeo G, Puzzolo D, et al. Impression
  • cytology of the conjunctival epithelium in patients with
  • vernal conjunctivitis. Eye 1996;10:82-85.
  • Rifaioglu E, Şen B, Ekiz Ö, Dogramaci A. Neutrophil
  • to lymphocyte ratio in Behcet’s disease as a marker of
  • disease activity. Acta Dermatovenerol Alp Pannonica
  • Adriat 2014;23:65-67.
  • Akboğa MK, Akyel A, Şahinarslan A, et al. Neutrophil
  • to lymphocyte ratio is increased in patients with rheumatic
  • mitral valve disease. Anadolu Kardiyol Derg
  • ; [Epub ahead of print]
  • Oray M, Toker E. Tear cytokine levels in vernal keratoconjunctivitis:
  • the effect of topical 0.05% cyclosporine
  • a therapy. Cornea 2013;32:1149-1154.
  • Çatak O, Aydemir O, Üstündağ B. Vernal keratokonjonktivitte
  • gözyaşı interlökin-16 düzeyleri. Dicle Med J
  • ;40:422-425.

Vernal keratokonjonktivitli olgularda ortalama trombosit hacmi ve nötrofil/lenfosit oranı

Yıl 2015, , 40 - 43, 10.05.2015
https://doi.org/10.5799/ahinjs.01.2015.01.0483

Öz

Amaç: Bu çalışmada vernal keratokonjonktiviti (VKK) olan hastaların nötrofil, eozinofil, lenfosit, trombosit sayı- sı, nötrofil/lenfosit oranı (NLO), ortalama trombosit hacmi (MPV) değerlendirilmesi amaçlanmıştır. Yöntemler: Bu çalışmada göz hastalıkları polikliniğine başvurmuş ve VKK tanısı almış olguların dosya kayıtları retrospektif olarak incelendi. Şaşılık dışında herhangi bir sistemik ve oküler hastalığı bulunmayan yaş ve cinsiyet uyumlu olgular kontrol grubuna dahil edildi. Tüm katı- lımcıların yaş ve cinsiyet verileri kaydedildi. Hemogram değerlerinden; MPV nötrofil, eozinofil, lenfosit, trombosit sayımı, NLO otomatik analizörlerle ölçüldü. Elde edilen veriler iki grup arasında karşılaştırıldı. Bulgular: Çalışma kapsamında 30 VKK ve 30 kontrol olgusu değerlendirildi. Gruplar arasında yaş ve cinsiyet açısından anlamlı farklılık saptanmadı. MPV ve NLO, VKK grubunda kontrol grubuna oranla daha yüksek olmasına rağmen istatistiksel olarak anlamlı değildi (sırasıyla p=0,19 ve p=0,16). Sonuç: Bu çalışmanın sonucunda MPV ve NLO değerlerinin VKK hastalığıyla ilişkili olmadığını gösterilmiştir. MPV ve NLO değerlerinin VKK’da istatistiksel olarak anlamlı olmamalarına rağmen daha yüksek olması VKK için yardımcı parametre olarak kullanılabilir. Anahtar kelimeler: Nötrofil lenfosit oranı, ortalama trombosit hacmi, vernal keratokonjonktivit

Kaynakça

  • Kanski JJ. Clinical ophthalmology. A systematic approach
  • nd ed Boston, Massachusetts: ButterworthHeinemann
  • ;629.
  • El-Asrar A.A, Al-Mansouri S, Tabbara K, et al. Immunopathogenesis
  • of conjunctival remodeling in vernal
  • keratoconjunctivitis. Eye 2005;20:71-79.
  • Bonini S, Bonini S, Lambiase A, et al. Vernal keratoconjunctivitis
  • revisited: a case series of 195 patients with
  • long-term follow up. Ophthalmology 2000;107:1157-
  • -
  • Kosrirukvongs P, Vichyanond P, Wongsawad W. Vernal
  • keratoconjunctivitis in Thailand. Asian Pac J Allergy
  • Immunol 2003;21:25-30.
  • Şahin A, Şahin M, Yüksel H, et al. The mean platelet
  • volume in patients with retinal vein occlusion. J Ophthalmol
  • ;236371.
  • Çil H, Yavuz C, İslamoğlu Y, et al. Platelet count and
  • mean platelet volume in patients with in-hospital
  • deep venous thrombosis. Clin Appl Thromb Hemost
  • ;18:650-653.
  • Giles H, Smith R, Martin J. Platelet glycoprotein IIb-IIIa
  • and size are increased in acute myocardial infarction.
  • Eur J Clin Invest. 1994;24:69-72.
  • Alkhouri N, Morris SG, Campbell C, et al. Neutrophil
  • to lymphocyte ratio: a new marker for predicting steatohepatitis
  • and fibrosis in patients with nonalcoholic
  • fatty liver disease. Liver Int 2012;32:297-302.
  • Cho SY, Lee A, Lee HJ, et al. Mean platelet volume
  • in Korean patients with hepatic diseases. Platelets
  • ;23:648-649.
  • Arikanoglu A, Yucel Y, Acar A, et al. The relationship of
  • the mean platelet volume and C-reactive protein levels
  • with mortality in ischemic stroke patients. Eur Rev
  • Med Pharmacol Sci 2013;17:1774-1777.
  • Celik T, Kaya M.G, Akpek M, et al, Predictive value
  • of admission platelet volume indices for in-hospital
  • major adverse cardiovascular events in acute STsegment
  • elevation myocardial infarction. Angiology
  • ;66:155-162
  • Ranjith M, Divya R, Mehta V, et al. Significance of
  • platelet volume indices and platelet count in ischaemic
  • heart disease. J Clin Pathol 2009;62:830-833.
  • Hourani S, Cusack N. Pharmacological receptors on
  • blood platelets. Pharmacol Rev 1991;43:243-298.
  • Baudouin C, Liang H, Bremond G.D, et al. CCR4 and
  • CCR5 expression in conjunctival specimens as differential
  • markers of T< sub> H</sub> 1/T< sub> H</
  • sub> 2 in ocular surface disorders. J Allergy Clin Immunol
  • ;116:614-619.
  • Aragona P, Romeo G, Puzzolo D, et al. Impression
  • cytology of the conjunctival epithelium in patients with
  • vernal conjunctivitis. Eye 1996;10:82-85.
  • Rifaioglu E, Şen B, Ekiz Ö, Dogramaci A. Neutrophil
  • to lymphocyte ratio in Behcet’s disease as a marker of
  • disease activity. Acta Dermatovenerol Alp Pannonica
  • Adriat 2014;23:65-67.
  • Akboğa MK, Akyel A, Şahinarslan A, et al. Neutrophil
  • to lymphocyte ratio is increased in patients with rheumatic
  • mitral valve disease. Anadolu Kardiyol Derg
  • ; [Epub ahead of print]
  • Oray M, Toker E. Tear cytokine levels in vernal keratoconjunctivitis:
  • the effect of topical 0.05% cyclosporine
  • a therapy. Cornea 2013;32:1149-1154.
  • Çatak O, Aydemir O, Üstündağ B. Vernal keratokonjonktivitte
  • gözyaşı interlökin-16 düzeyleri. Dicle Med J
  • ;40:422-425.
Toplam 66 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Yazısı
Yazarlar

Bilal Elbey Bu kişi benim

Ümit Yazgan Bu kişi benim

Adnan Yıldırım Bu kişi benim

Ümit Karaalp Bu kişi benim

Alparslan Şahin Bu kişi benim

Yayımlanma Tarihi 10 Mayıs 2015
Yayımlandığı Sayı Yıl 2015

Kaynak Göster

APA Elbey, B., Yazgan, Ü., Yıldırım, A., Karaalp, Ü., vd. (2015). Vernal keratokonjonktivitli olgularda ortalama trombosit hacmi ve nötrofil/lenfosit oranı. Journal of Clinical and Experimental Investigations, 6(1), 40-43. https://doi.org/10.5799/ahinjs.01.2015.01.0483
AMA Elbey B, Yazgan Ü, Yıldırım A, Karaalp Ü, Şahin A. Vernal keratokonjonktivitli olgularda ortalama trombosit hacmi ve nötrofil/lenfosit oranı. J Clin Exp Invest. Mayıs 2015;6(1):40-43. doi:10.5799/ahinjs.01.2015.01.0483
Chicago Elbey, Bilal, Ümit Yazgan, Adnan Yıldırım, Ümit Karaalp, ve Alparslan Şahin. “Vernal Keratokonjonktivitli Olgularda Ortalama Trombosit Hacmi Ve nötrofil/Lenfosit Oranı”. Journal of Clinical and Experimental Investigations 6, sy. 1 (Mayıs 2015): 40-43. https://doi.org/10.5799/ahinjs.01.2015.01.0483.
EndNote Elbey B, Yazgan Ü, Yıldırım A, Karaalp Ü, Şahin A (01 Mayıs 2015) Vernal keratokonjonktivitli olgularda ortalama trombosit hacmi ve nötrofil/lenfosit oranı. Journal of Clinical and Experimental Investigations 6 1 40–43.
IEEE B. Elbey, Ü. Yazgan, A. Yıldırım, Ü. Karaalp, ve A. Şahin, “Vernal keratokonjonktivitli olgularda ortalama trombosit hacmi ve nötrofil/lenfosit oranı”, J Clin Exp Invest, c. 6, sy. 1, ss. 40–43, 2015, doi: 10.5799/ahinjs.01.2015.01.0483.
ISNAD Elbey, Bilal vd. “Vernal Keratokonjonktivitli Olgularda Ortalama Trombosit Hacmi Ve nötrofil/Lenfosit Oranı”. Journal of Clinical and Experimental Investigations 6/1 (Mayıs 2015), 40-43. https://doi.org/10.5799/ahinjs.01.2015.01.0483.
JAMA Elbey B, Yazgan Ü, Yıldırım A, Karaalp Ü, Şahin A. Vernal keratokonjonktivitli olgularda ortalama trombosit hacmi ve nötrofil/lenfosit oranı. J Clin Exp Invest. 2015;6:40–43.
MLA Elbey, Bilal vd. “Vernal Keratokonjonktivitli Olgularda Ortalama Trombosit Hacmi Ve nötrofil/Lenfosit Oranı”. Journal of Clinical and Experimental Investigations, c. 6, sy. 1, 2015, ss. 40-43, doi:10.5799/ahinjs.01.2015.01.0483.
Vancouver Elbey B, Yazgan Ü, Yıldırım A, Karaalp Ü, Şahin A. Vernal keratokonjonktivitli olgularda ortalama trombosit hacmi ve nötrofil/lenfosit oranı. J Clin Exp Invest. 2015;6(1):40-3.