Cistus Incanus Bitki Özünün Anti-Enfektif Özellikleri

Öz

Dünyada en yaygın hastalık olan üst solunum yolu enfeksi- yonları ÜSYE yüksek morbidite, mortalite ve ekonomik kayıplara yol açmaktadır. ÜSYE etiyolojisinde en sık sapta- nan patojenler viruslardır. Korunma ve tedavi amaçlı bir- çok antiviral özellikte madde geliştirilmiştir. Cystus052, Cistus incanus bitkisinden elde edilen bir bitki özütü olup, polimerik polifenollerden zengindir ve antiviral etkinliği gösterilmiştir. Bu makalede Cistus incanus bitki özütünün özellikleri ve etkinliği değerlendirilmektedir

Anahtar Kelimeler

• Cistus,polifenoller,üst solunum yolu enfeksiyonları,antiviral ajanlar

Anti-infective Properties of Cistus Incanus, a Plant Extract

Öz

The most common diseases in the world are upper respira- tory tract infections, resulting in substantial morbidity, mortality, and financial loss. Viruses are reported to be the most important pathogens involved in URT etiology. Several antiviral compounds have been developed for tre- atment, and prophylaxis. Cystus052, a an extract from a special variety of Cistus incanus plant that is rich in poly- meric polyphenols, has been shown to exhibit antiviral activity. In this article, the properties and efficacy of Cistus incanus are reviewed

Anahtar Kelimeler

• Cistus,polyphenols,upper respiratory infections,antiviral agents

Kaynakça

1. Cos P, De Bruyne T, Hermans N, Apers S, Vanden Berghe D, Vlietinck AJ. Proanthocyanidins in health care: current and new trends. Curr Med Chem 2004;11:1345-59. http://dx.doi.org/10.2174/0929867043365288
2. Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shimamura T. Inhibition of the infectivity of influenza virus by tea polyphenols. Antiviral Res 1993;21:289-99. http://dx.doi.org/10.1016/0166-3542(93)90008-7
3. Urquiaga I, Leighton F. Plant polyphenol antioxidants and oxidative stress. Biol Res 2000;33:55-64. http://dx.doi.org/10.4067/S0716-97602000000200004
4. Ehrhardt C, Hrincius, ER, Korte V, Mazur I, Droebner K, et al. A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance. Antiviral Res 2007;76:38-47. http://dx.doi.org/10.1016/j.antiviral.2007.05.002
5. Kalusa U, Grigorova A, Kadeckib O, Jansenc JP, Kiesewettera H, Radtkea H. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract A prospective, randomised, placebo-controlled clinical study. Antiviral Research 2009;84:267-71. http://dx.doi.org/10.1016/j.antiviral.2009.10.001
6. Kalus U, Kiesewetter H, Radtke H. Effect of CYSTUS052 and green tea on subjective symptoms in patients with infection of the upper respiratory tract. Phytother Res 2010;24:96-100. http://dx.doi.org/10.1002/ptr.2876
7. Kiesewetter H. Cystussud zur lokalen Behandlung der Tonsillopharyngitis. Erfahrungsheilkunge 2002;11:792- 93.
8. Rebensburg S, Helfer M, Schneider M, Herwig Koppensteiner H, Eberle J, et al. Potent in vitro anti- viral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins. Scientific Reports 2016;6:20394. http://dx.doi.org/10.1038/srep20394

9. Wittpahl G, Kölling-Speer I, Basche S, Herrmann E, Hannig M, Speer K, et al. The polyphenolic com- position of Cistus incanus herbal tea and its antibacte- rial and anti-adherent activity against Streptococcus mutans. Planta Med 2015;81:1727-35. http://dx.doi.org/10.1055/s-0035-1557822
10. Kalliomaki M, Antoine JM, Herz U, Rijkers GT, Wells JM, Mercenier A. Guidance for substantiating the evidence for beneficial effects of probiotics: pre- vention and management of allergic diseases by probi- otics. J Nutr 2010;140:713-21. http://dx.doi.org/10.3945/jn.109.113761
11. Singh A, Holvoet S, Mercenier A. Dietary polyphenols in the prevention and treatment of allergic diseases. Clinical & Experimental Allergy 2011;41:1346-59. http://dx.doi.org/10.1111/j.1365-2222.2011.03773.x