Akut Gomerülonefritler

Öz

Akut glomerülonefrit AGN , glomerüllerdeki akut seyirli bir inflamasyonun oluşturduğu bir klinik sendromdur. Tipik başvuru bulguları, makroskopik hematüri, hipertan- siyon ve ödem üçlüsünden oluşur. Çocuklarda AGN’nin en sık nedeni poststreptokoksik glomerülonefrittir. Geçirilmiş bir streptokok enfeksiyonu kanıtı olup olmadı- ğı ve serum kompleman seviyesi AGN ayırıcı tanısında yol göstericidir. Tipik APSGN vakalarında böbrek biyopsisi endikasyonu yoktur. AGN etiyolojisine bakılmaksızın tüm hastalara öncelikle destek tedavisi uygulanır. Çocuklarda APSGN’nin kısa ve uzun dönem prognozu genellikle iyi- dir. Streptokok enfeksiyonlarına karşı etkin ve güvenli aşıların geliştirilmesi için çok sayıda klinik çalışma hâlen yürütülmektedir

Anahtar Kelimeler

• Akut glomerülonefrit,streptokok enfeksiyonu,hematüri,ASO

Acute Glomerulonephritis

Öz

Acute glomerulonephritis AGN is a clinical syndrome which is associated with an acutely coırsing glomerular inflammation. The typical triad of its presenting symptoms is macroscopic hematuria, hypertension and edema. In children, the most common cause of AGN is poststreptococ- cal glomerulonefritis. The evidence /if any of previously experienced streptoccal infection, and serum complement level provide guidance for the differential diagnosis of AGN. In cases with typical APSGN there is no indication of kidney biopsy. The primary medical care of all patients is supportive, regardless of the etiology of AGN. Short term- and long-term outcomes are generally favorable in child- ren with APSGN Many clinical trials are currently procee- ding for the development of both effective and safe vaccines against streptococcal infections

Anahtar Kelimeler

• Acute glomerulonephritis,streptococcal infection,hematuria,ASO

Kaynakça

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