Günümüzde Sefalosporinler ve Antibiyotik Direnci

Öz

Sefalosporinler günümüzde yaygın olarak kullanılan bir antibiyotik grubudur. Birinci ve ikinci kuşlak sefalospo- rinlerin gram pozitif etkinlikleri fazla iken, üçüncü kuşak sefalosporinlerde gram negatif etkinlik hâkimdir. Sefalosporinler ayaktan parenteral tedavi prensiplerine de uygundur. Solunum yolu enfeksiyonları, üriner sistem enfeksiyonları, yumuşak doku enfeksiyonları, kemik ve iskelet sistemi enfeksiyonları, merkez sinir sistemi enfek- siyonları, bakteriyemi ve gonorede etkindir. Sefalosporinler bakterisidal, beta-laktamaza dirençli, vücut dokularına dağılımı iyi olan hem oral hem de parenteral kullanılabi- len ilaçlardır

Anahtar Kelimeler

• Antibiyotik,sefalosporin,direnç

Cephalosporin Antibiotics and Antibiotic Resistance in Daily Practice

Öz

Nowadays, cephalosporins are commonly used antibiotics in pediatrics. First and second- generation cephalosporins have been used for infectious diseases caused by gram posi- tive bacteria but third- generation cephalosporins are pre- ferred for gram negative bacterial infections. Cephalosporins are also suitable for outpatient parenteral treatment They are effective in respiratory tract infections, urinary system infections, soft tissue infections, skeletal infections, central nervous system infections, bacteremia, and gonorrhea. Cephalosporins can be used through both oral, and parente- ral routes. They are bactericidal, and resistant to β-lactamase with good distribution into tissues

Anahtar Kelimeler

• Antibiotic,cephalosporin,resistance

Kaynakça

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