Çocuklarda Besin Allerjisi ve D Vitamini İlişkisi

Yıl 2013, , 55 - 60, 01.04.2013

Serap Özmen Şennur Keleş

https://doi.org/10.5222/j.child.2013.055

Öz

Allerjik hastalıkların prevalansının son yıllarda tüm dünyada artışının yanı sıra D vitamini eksikliği veya yetersizliği de yaygın olarak görülmektedir. Vitamin D eksikliğinin atopik dermatit, astım ve yineleyen vizing ile ilişkisi çeşitli çalışmalarla araştırılmıştır. Besin allerjisi ile vitamin D arasındaki olası birliktelik ilk kez epidemi- yolojik çalışmalarda dikkati çekmiştir. Gebelikte D vita- mini alımı, maternal veya kordon kanında vit D düzeyi- nin besin allerjisi üzerinde koruyucu, arttırıcı veya etkisiz olduğuna sonuçlar elde edilmiştir. Çocuklarda yapılan az sayıdaki çalışmada vit D eksikliğinde besin yerfıstığı ve yumurta allerjisinin arttığı saptanmıştır. Besin duyarlanması-vitamin D ve gen etkileşimi incelen- diğinde, vit D eksikliğinin belirli genotiplerde besin duyarlanmasını arttırdığı bulunmuştur. Sonuç olarak, besin allerjisi ve vit D arasındaki ilişkiyi araştıran çalış- malar olmasına rağmen, sonuçları çelişkilidir. Bu neden- le çocuklardaki besin allerjisinde çocuk sağlığındaki geçerli bilgiler eşliğinde doğru vitamin uygulaması yapılmalıdır

Anahtar Kelimeler

Besin allerjisi, besin duyarlanması, çocuk, vitamin D, vitamin D eksikliği

The Relationship Between Food Allergy and Vitamin D in Children

Öz

Vitamin D deficiency or insufficiency as well as an increase in the prevalence of allergic diseases has been widely observed all over the world in recent years. The relations- hip between vitamin D deficiency and atopic dermatitis, asthma, and recurrent wheezing has been investigated in several studies. The probable coexistence of food allergy and vitamin D has drawn attention to the first time in the epidemiological studies. Vitamin D intake during preg- nancy and maternal or cord blood levels of vitamin D have been found to be protective, relatively more effective or ineffective in food allergy. A few studies have been determi- ned that food peanut and egg allergies increased with the deficiency of vitamin D in children. An analysis of food sensitization-vitamin D and gene interaction has shown that vitamin D deficiency increases food sensitization in specific genotypes. As a result, although there are some studies investigating the relationship between food allergy and vitamin D, the results of these studies are conflicting. For this reason, correct vitamin supplementation with regard to current available information about child health should be applied in children with food allergy

Anahtar Kelimeler

Children, food allergy, food sensitivity, vitamin D, vitamin D deficiency

Kaynakça

• misra m, Pacaud D, Petryk A, Collett-Solberg PF, Kappy m. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Pediatrics 2008;122(2):398. http://dx.doi.org/10.1542/peds.2007-1894 PMid:18676559
• Cm, Hanley DA, Haeney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine society clinical practise guideline. J Clin Endocrinol Metab 2011;96: 30. http://dx.doi.org/10.1210/jc.2011-0385 PMid:21646368 global perspective of current status. J Nutr 2005;135(2): 6. PMid:15671233
• Hughes B, eisman JA et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009;20: 20. http://dx.doi.org/10.1007/s00198-009-0954-6 PMid:19543765 (3):266-81.
• Ann Allergy Asthma Immunol 2010;105:191-9. http://dx.doi.org/10.1016/j.anai.2010.01.013 PMid:20800785
• Ahonen S, Nevalainen J, et al. Maternal vitamin D intake during pregnancy is inversly associated with asthma and aller- gic rhinitis in 5 –year-old children. Clin Exp Allergy 2009;39: 82. http://dx.doi.org/10.1111/j.1365-2222.2009.03234.x PMid:19522996 edwards JW, Weiss ST, Gold DR, et al. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr 2007;85:788-95. PMid:17344501
• G, Martindale S, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr ;85:853-9. PMid:17344509
• Henderson J, lawlor DA. Prospective association of hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis. Epidemiology ;24(2):310-9. http://dx.doi.org/10.1097/EDE.obo13e318280dd5e PMid:23377091
• Camargo CA Jr, Clark S, Kaplan MS, lieberman P, Wood RA. Regional differences in EpiPen prescriptions in the United States: The potential role of vitamin D. J Allergy Clin Immunol 2007;120:131-6.
• Mullins RJ, Clark S, Camargo CA Jr. Regional variation in epinephrine autoinjector prescriptions in Australia: more evi- dence for the vitamin D-anaphylaxis hypothesis. Ann Allergy Asthma Immunol 2009;103(6):488-95. http://dx.doi.org/10.1016/S1081-1206(10)60265-7 rences in US emercency department visits for acute allergic reactions. Ann Allergy Asthma Immunol 2010;104:413-6. http://dx.doi.org/10.1016/j.anai.2010.01.022 PMid:20486331
• Prevalence of eczema and food allergy is accociated with lat- titude in Australia. J Allergy Clin Immunol 2012;129(3): 7. http://dx.doi.org/10.1016/j.jaci.2012.01.037 PMid:22305679
• Camargo CA Jr. Season of Birth is Associated with Food Allergy in Children. Ann Allergy Asthma Immunol 2010; (4):307-13. http://dx.doi.org/10.1016/j.anai.2010.01.019 PMid:20408340 PMCid:PMC2941399 risk factors of immediate type food allergy during the first year of life in Korean infants: a birth cohort study. Pediatr Allergy 2011;22(7):715-9. http://dx.doi.org/10.1111/j.1399-3038.2011.01163.x PMid:21539613
• Mullins RJ, Clark S, Katelaris C, Smith V, Solley G, Camargo CA Jr. Season birth and childhood food allergy in Australia. Pediatr Allergy Immunol 2011;22(6):583-9. http://dx.doi.org/10.1111/j.1399-3038.2011.01151.x PMid:21342281
• Skripak J, Peng RD, Wood RA. Potential mechanisms for the association between fall birth and food allergy. Allergy ;67:775-82. http://dx.doi.org/10.1111/j.1398-9995.2012.02823.x PMid:22515802 PMCid:PMC3349789
• T, Nishikomori R, Heike T. Effect of eczema on the associa- tion between season of birth and food allergy in Japanese children. Pediatr Int 2013;55(1):7-10. http://dx.doi.org/10.1111/j.1442-200X.2012.03725.x PMid:22978473
• Kronberg-Kippila C, et al. Maternal diet during pregnancy and allergic sensitization in the offsprings by 5 yrs of age: a prospective cohort study. Pediatr Allergy Immunol 2010;21:29- http://dx.doi.org/10.1111/j.1399-3038.2009.00949.x PMid:20003068
• G, Martindale S, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr ;85:853-9. Hydroxyvitamin D3 and allergic disease during infancy. Pediatrics 2012;130:e1128-1135. http://dx.doi.org/10.1542/peds.2012-1172 PMid:23090338
• Fahrlander C, et al. Maternal vitamin d intake during preg- nancy increases gene expression of ILT3 and ILT4 in cord blood. Clin Exp Allergy 2010;40(5):786-94. http://dx.doi.org/10.1111/j.1365-2222.2009.03428.x PMid:20030662
• Neonatal vitamin D status and childhood peanut allergy: a pilot study. Ann Allergy Asthma Immunol 2012;109(5): 8. http://dx.doi.org/10.1016/j.anai.2012.07.009 PMid:23062387
• Rothers J, Wright Al, Stern DA, Halonen M, Camargo CA Jr. Cord blood 25-hydroxyvitamin D levels are associated with aeroallergen sensitization in children from Tuscon, Arizona. J Allergy Clin Immunol 2011;128(5):1093-9. http://dx.doi.org/10.1016/j.jaci.2011.07.015 PMid:21855975 PMCid:PMC3205280 m, et al. Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy 2013;68:220-8. http://dx.doi.org/10.1111/all.12081 PMid:23253182
• Vitamin D levels and food and environmental allergies in the United States: Results from the National Health and Nutrition Examination survey 2005-2006. J Allergy Clin Immunol 2011; (5):1195-1202. http://dx.doi.org/10.1016/j.jaci.2011.01.017 PMid:21329969 PMCid:PMC3085636
• Vuillermin P, et al. Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol 2013;131(4):1109-16. http://dx.doi.org/10.1016/j.jaci.2013.01.017 PMid:23453797 lementation and allergic conditions in adulthood: northern
• Finland birth cohort 1966. Ann N Y Acad Scie 2004;1037: 95. http://dx.doi.org/10.1196/annals.1337.013 PMid:15699498
• Milner JD, Stein DM, McCarter R, Moon RY. Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics 2004;114:27-32. http://dx.doi.org/10.1542/peds.114.1.27 PMid:15231904
• Kull I, Bergström A, Melen e, lilja G, van Hage M, Pershagen G, et al. Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood. J Allergy Clin Immunol 2006; :1299-304. liu X, Wang G, Hong X, et al. Gene-vitamin D interactions on food sensitization: a prospective birth cohort study. Allergy ;66:1442-48. http://dx.doi.org/10.1111/j.1398-9995.2011.02681.x PMid:21819409 PMCid:PMC3189275
• Meurs JB, Berry D, Kiel DP, et al. Common genetic deter- minants of vitamin D insufficiency: a genome-wide associati- on study. Lancet 2010;17;376(9736):180-8.
• Clinton SK, et al. The 2011 report on dietary reference inta- kes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011; (1):53-8. http://dx.doi.org/10.1210/jc.2010-2704 PMid:21118827 PMCid:PMC3046611
• Endorsement: Dietary reference intakes for calcium and vita- min D. Pediatrics 2012;130:5 e1424.
• S, et al. Vitamin D deficiency in Turkish mothers and their neonates and in women of reproductive age. J Clin Res Pediatr Endocrinol 2009;1(6):266-9. http://dx.doi.org/10.4274/jcrpe.v1i6.266 PMid:21274307 PMCid:PMC3005757
• Yaprak I, et al. Vitamin D deficiency in pregnant women and their neonates in spring time in western Turkey. Paediatr Perinat Epidemiol 2012;26(1):53-60. http://dx.doi.org/10.1111/j.1365-3016.2011.01238.x PMid:22150708