Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin ve Pridoksin Kullanımı: Vaka Sunumu

Öz

Bir vinka alkaloidi olan vinkristin VCR , çocukluk çağı kanserlerinin tedavisinde yaygın olarak kullanılan bir kemoteropatiktir. Vinkristinin nörotoksik etkileri kullanı- mını sınırlayıcı bir faktördür. Bu nörotoksik etkiler, peri- feral nöropati, otonomik nöropati, kranial sinir felçleri ve ensefalopati olmak üzere dört gruba ayrılmaktadır. Nöropatinin ciddiyeti tedavinin süresi ve toplam doz ile ilişkilidir. Semptomların çoğu ilacın kesilmesi ile düzel- mektedir. Biz burada, daha önce bilinen kalıtsal bir nöro- patisi olmadığı halde VCR tedavisini takiben parsiyel intestinal obstrüksiyon gelişen, pridoksin ve pridostigmin ile tedavi ettiğimiz sekiz yaşında bir erkek vakayı sun- duk

Anahtar Kelimeler

• Vinkristin,nörotoksisite,parsiyel intestinal obstrüksiyon,pridoksin,pridostigmin

Pyridoxine and Pyridostigmine Use in Vincristine-Induced Partial Intestinal Obstruction: Case Report

Öz

The vinca alkoloid, vincristine VCR is a commonly used chemotherapeutic agent in the treatment of pediatric malignancies. Its neurotoxic effects are the limiting fac- tors for the use of the drug. Neurotoxic effects may be divided into four groups as peripheral neuropathy, auto- nomic neuropathy, cranial nerve neuropathy and encep- halopathy. The severity of neuropathy is related to the total dose and duration of the therapy. Most of the symptoms improves after withdrawal of the drug. We pre- sented an 8 year-old boy without hereditary neuropathy, who suffered from partial intestinal obstruction following vincristine therapy and treated by using pyridoxine and pyridostigmine

Anahtar Kelimeler

• Vincristine,neurotoxicity,partial intestinal obstruction,pyridoxine,pyridostigmine

Kaynakça

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