Prematüre Retinopatisi Tarama Sonuçlarımız

Öz

Amaç: Çalışma Prematüre Retinopatisinin PR sıklığını ve risk faktörlerini saptamak amacıyla yapıldı. Yöntem: Çalışmaya Mersin Üniversitesi Tıp Fakültesi Yenidoğan Yoğun Bakım Ünitesi’nde, Ocak ve Aralık 2007 tarihleri arasında yatırılarak izlenen ve PR taraması yapılan 52 bebek alındı. Bulgular: Bebeklerin ortalama doğum ağırlığı 1327±378 g 690-2350 , ortalama gebelik yaşı 30.1±2.8 hafta 23-36 idi. Elli iki bebeğin dördünde % 7.6 PR saptandı. PR’li dört bebeğin ağırlığı 1280 g ve altındaydı. Bronkopulmoner displazi sıklığı PR’li bebeklerde daha yüksek bulundu. PR’li bebeklerin olduğu gruplarda bronkopulmoner displazi, düşük doğum ağırlığı, küçük gebelik yaşı, düşük Apgar skoru, kan transfüzyonu sıklığı ve oksijen tedavisi süresi uzunluğu daha yüksek bulundu. Sonuç: PR çok etkenli bir hastalık olarak bilinmektedir. Düzenli tarama ve olası risk faktörlerinden kaçınma PR’nin neden olduğu körlüğü azaltabili

Anahtar Kelimeler

• Retinopati,prematürite,risk faktörleri,sıklık

Results of Screening for Retinopathy of Prematurity

Öz

Objective: This study was designed to determine the frequency and risk factors for retinopathy of prematurity ROP . Methods: Between January and December 2007, fifty-two preterm babies who were hospitalized in Neonatal Intensive Care Unit of Mersin University were evaluated for ROP. Results: The mean birth weight was 1327±378 grams 690-2350 , the mean gestational age was 30.1±2.8 weeks 23-36 . ROP was detected in four, out of 52 preterm babies 7.6 % . Birth weights of all 4 infants were less than 1280 grams. The rate of bronchopulmonary dysplasia was higher in the infants who have ROP. The rate of bronchopulmonary dysplasia, low birth weight, low gestational age, low Apgar scores, blood transfusion and longer durations of oxygen therapy were higher in babies with ROP. Conclusions: ROP is known as a multifactorial disease. Regular screening and avoiding from possible risk factors may reduce the blindness caused by ROP

Anahtar Kelimeler

• Retinopathy,prematurity,risk factors,incidence

Kaynakça

1. 1. Chow L, Wright K, Sola A. Can changes in clinical practice decrease the incidence of severe retinopathy. Pediatrics 2003; 111:339-45.
2. 2. Fleck B, Mclntosh N. Pathogenesis of retinopathy of prematurity and possible preventive strategies. Early Hum Dev 2008; 84:83-8.
3. 3. Section on Ophthalmology, American Academy of Pediatrics, American Academy of Ophthalmology and American Association for Pediatric Ophthalmology and Strabismus. Screening Examination of Premature Infants for Retinopathy of Prematurity. Pediatrics 2006; 117:572-6.
4. 4. Gilbert C. Retinopathy of prematurity: A global perspective of the epidemics, population of babies at risk and implications for control. Early Hum Dev 2008; 84:77-82.
5. 5. Fielder AR, Posner EJ. Neonatal ophthalmology. In: Rennie JM (ed). Roberton’s textbook of Neonatology. 4th ed. London: Elsevier 2005: 835-50.
6. 6. Chawla D, Agarwal R, Deorari A, Paul V. Retinopathy of prematurity. Indian J Pediatr 2008; 75:73-6.
7. 7. Bullard S, Donahue S, Feman S, Sinatra R, Walsh W. The decreasing ıncidence and severity of retinopathy of prematu- rity. Journal of AAPOS 1999; 3:46-52.
8. 8. Englert J, Saunders R, Purohit D, Hulsey T, Ebeling M. The effect of anemia on retinopathy of prematurity in extremely low birth weight infants. Journal of Perinatology 2001; 21:21-6.

9. 9. Özkan H, Köksal N. Prematüre retinopatisi. Güncel Pediatri 2005; 2:24-8.
10. 10. Palmer E. The factor of time in retinopathy of prematurity. J AAPOS 2006; 10:500-6.
11. 11. Wilkinson AR, Haines L, Head K, Fielder AR. UK retinopathy of prematurity guideline. Early Hum Dev 2008; 84:71-4.
12. 12. Fierson W, Palmer E, Biglan A, Flynn J, Petersen R and Phelps D. Screening Examination of Premature Infants for Retinopathy of Prematurity. A Joint Statement of the American Academy of Pediatrics, the American Association for Pediatric Ophthalmology and Strabismus, and the American Academy of Ophthalmology. Pediatrics 1997; 100:273-4.
13. 13. Vinekar A, Dogra M, Sangtam T, Narang A, Gupta A. Retinopathy of prematurity in Asian Indian babies weighing greater than 1250 grams at birth: Ten year data from a tertiary care center in a developing country. Indian J Ophthalmol 2007; 55:331-6.
14. 14. Drack A. Retinopathy of prematurity. Advances in Pediatrics 2006; 53:211-26.
15. 15. International Committee. An international classification of retinopathy of prematurity. Br J Ophthalmol 1984;68:690-7.
16. 16. O’Conner A, Fielder A. Long term ophtalmic sequelae of prematurity. Early Hum Dev 2008; 84:101-6.
17. 17. Wright Kh W, Sami D, Lisa T, Ramanathan R, Joseph R, Farzavandi S. A physiologic reduced oxygen protocol decreases the incidence of threshold retinopathy of prematurity. Trans Am Ophthalmol Soc 2006; 104:78-84.
18. 18. Rodriguez FJ, Canizares JM. Screening For Retinopathy Of Prematurity. Our experience about limits of birth weight, Postconceptional age and others risk factors. Arch Soc Esp Oftalmol 2006; 81:275-80.
19. 19. Akkoyun I, Oto S, Yilmaz G, Gurakan B, Tarcan A, Anuk D, Akgun S, Akova Y. Risk factors in the development of mild and severe retinopathy of prematurity. Journal of AAPOS 2006; 10:449-53.
20. 20. Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis 2007; 10:133-40.
21. 21. Kulaçoğlu D, Sertöz A, Ateş O, Baykal O. Prematüre retinopatisinde risk faktörleri ve tarama sonuçları. Ret – Vit 2005; 13:33-7.
22. 22. Gaynon M. Rethinking STOP-ROP: Is it worthwhile trying to modulate excessive VEGF levels in prethreshold rop eyes by systemic intervention?: A Review of the Role of Oxygen, Light Adaptation State, and Anemia in Prethreshold ROP. The Ophthalmic Communications Society 2006; 26:18-23.
23. 23. Italian multicentre study on retinopathy of prematurity. The Italian ROP Study Group. Eur J Pediatr 1997; 156:939-43.
24. 24. Patz A, Hoeck LE, DeLaCruz E. Studies on the effect of high oxygen administration in retrolental fibroplasia. Am J Ophthalmol 1952; 35:1248-52.
25. 25. Crosse VM. The problem of retrolental fibroplasia in the City of Birmingham. Trans Ophthalmol Soc UK 1951; 71:609-12.
26. 26. Lin HJ, Lin CC, Tsai SW, Lin HC, Su BH. Risk factors for retinopathy of prematurity in very low birth weight infants. J Chin Med Assoc 2003; 66:662-8.
27. 27. Yalaz M, Arslanoğlu S, Erakgün E, Yurtsever S, Akisü M, Akkın C, Menteş J, Kültürsay N. Prematüre retinopatisi risk faktörleri ve koruyucu önlemler. T Klin Pediatr 2003; 12:1-8.
28. 28. Türkmen M, Altıncık A, Acar Ç, Tosun A, Aydoğdu A. Adnan Menderes Üniversitesi Tıp Fakültesi Yenidoğan Yoğun Bakım Ünitesinde izlenen çok düşük doğum ağırlıklı bebeklerin değerlendirilmesi. ADÜ Tıp Fakültesi Dergisi 2006; 7:3-6.
29. 29. Kavuncuoğlu S, Karaçorlu M, Arıdaşır Ö, Arası C, Yılmaz Ç, Arslan G, Palabıyık M, Öztürk H. Riskli prematürelerde retinopati taraması ve sonuçları. Türk Pediatri Arşivi 2002; 37:10-4.
30. 30. Öner A, Özkırış A, Güneş T, Karaküçük S, Erkılıç K, Çetin N. Prematüre retinopatisi: 2 yıllık tarama sonuçlarımız. Erciyes Tıp Dergisi 2005; 27:104-9.
31. 31. Özbek E, Genel F, Güngör İ, Füsun A, Malatyalı R, Menteş J, Berk T. Prematüre servisimizde izlenen hastalarda prematüre retinopatisi sonuçları. 50. Milli Pediatri Kongresi, PP-072.