Influenza Infection in Infants Under One Year of Age

Yıl 2022, , 21 - 24, 18.05.2022

Mustafa Gençeli , Ozge Metin , Sevgi Pekcan , Yasemin Derya Gülseren , Mehmet Özdemir , Şükrü Güner , Ensar Karakaş

https://doi.org/10.26650/jchild.2022.890911

Öz

Objective: Influenza virus infections are infectious agents which lead to epidemics and pandemics, are associated with severe morbidity and mortality, and still maintain their importance worldwide. This study was planned due to the fact that influenza virus infections are associated with complications and hospitalizations in infants under 1 year of age. Material and Method: 56 infants diagnosed with influenza between October 2017 and February 2018 were retrospectively evaluated. Results: Mean age of the patients was 5.6±2.1 (2-11) months. Of the patients; 46.5% were followed-up in an inpatient setting and 53.5% in an outpatient setting. 22 patients were diagnosed by polymerase chain reaction method and 34 by rapid antigen test. Of the patients; 53.5% (n=30) were followed-up with diagnosis of upper respiratory tract infections, 33.9% (n=19) with pneumonia, 10.7% (n=6) with sepsis and 1.7% (n=1) with encephalitis. Mean duration of hospital stay was determined to be 8.32 (2-38) days. Conclusion: Influenza virus infections cause a high rate of hospitalizations in infants younger than one year old, it is necessary to determine with fast and accurate diagnostic methods, to arrange their treatment and to provide appropriate isolation measures.

Anahtar Kelimeler

Influenza, infant, polymerase chain reaction, rapid antigen testing

Destekleyen Kurum

NO SUPPORTING INSTITUTION

Bir Yaş Altı İnfantlarda İnfluenza Enfeksiyonu

Öz

Amaç: İnfluenza virüs enfeksiyonları epidemi ve pandemilerle seyreden, ciddi morbidite ve mortalite ile ilişkilendirilen, halen dünya genelinde önemini koruyan bir enfeksiyon etkenidir. Bir yaş altı infantlarda influenza virüs enfeksiyonlarının hospitalizasyon ve komplikasyonlarla ilişkisi olması sebebiyle bu çalışma planlanmıştır. Gereç ve Yöntem: Ekim 2017- Şubat 2018 tarihleri arasında influenza tanısı alan 56 infant retrospektif olarak değerlendirilmiştir. Bulgular: Hastaların ortalama yaşı 5,6±2,1 (2-11) ay idi. Hastaların %46,5’i hastaneye yatırılarak, %53,5’i ayaktan takip edildi. 22 hastaya polimeraz sincir reaksiyonu yöntemiyle, 34 hastaya hızlı antijen testi ile tanı konuldu. Hastaların %53,5’i (n=30) üst solunum yolu enfeksiyonu, %33,9’u (n=19) pnömoni, %10,7’si (n=6) sepsis, %1,7’si (n=1) ensefalit tanısıyla takip edildi. Ortalama yatış süresi 8,32 (2-38) gün olarak saptandı. Sonuç: İnfluenza virüs enfeksiyonları bir yaş altı infantlarda yüksek oranda hospitalizasyona sebep olmaktadır, hızlı ve doğru tanı yöntemleri ile belirlenerek tedavisinin düzenlenmesi ve uygun izolasyon önlemleri sağlanması gerekmektedir.

Anahtar Kelimeler

infant, polimeraz zincir reaksiyonu, hızlı antijen testi

Kaynakça

• 1. Fiore AE, Shay DK, Broder K, Iskander JK, Uyeki TM, Mootrey G, et al. Centers for Disease Control and Prevention (CDC); Advisory Committee on Immunization Practices (ACIP). Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). M. M. W. R. Recomm Rep 2008;57(7):1-60. google scholar
• 2. Ruf BR, Szucs T. Reducing the burden of influenza-associated complicationswithantiviraltherapy.Infection2009;37(3):186-196 google scholar
• 3. Poehling KA, Edwards KM, Weinberg GA, Szilagyi P, Staat MA, Iwane MK, et al. The underrecognized burden of influenza in young children. N Engl J Med 2006;355(1):31-40. google scholar
• 4. Viasus D, Revuelta JAO, Martı'nez-Montauti J, Carratalâ J. Influenza A(H1N1)pdm09-related pneumonia and other complications. Enferm Infecc Microbiol Clin 2012;4:43-8. google scholar
• 5. United States Centers for Disease Control and Prevention. H1N1 early outbreakand disease Characteristics http:// cdc.gov/h1n1flu/ surveillanceqa.htm, 2009. google scholar
• 6. Chaves SS, Perez A, Farley MM, Miller L, Schaffner W, Lindegren ML, et al. The burden of influenza hospitalizations in infants from 2003 to 2012, United States. Pediatr Infect Dis J 2014;33(9):912-9. google scholar
• 7. Uyeki TM. Oseltamivir Treatment of Influenza in Children. Clin Infect Dis 2018;2:66(10):1501-3. google scholar
• 8. Theo A, Tempia S, Cohen AL, Simusika P, Chentulo E, Chikamukwa CM, et al. The national burden of influenza-associated severe acute respiratory illness hospitalization in Zambia, 2011-2014. Influenza Other Respir Viruses 2018;12(1):46-53. google scholar
• 9. Hall CB. Clinical features and diagnosis of influenza in children. In: Basow DS (ed). UpToDate. version 18.3. Waltham, MA: UpToDate, Inc, 2011. google scholar
• 10. Okuno H, Yahata Y, Tanaka-Taya K, Arai S, Satoh H, Morino S, et al. Characteristics and Outcomes of Influenza- Associated Encephalopathy Cases Among Children and Adults in Japan, 20102015. Clin Infect Dis 2018;1;66(12):1831-7. google scholar
• 11. Paksu MS, Aslan K, Kendirli T, Akyildiz BN, Yener N, Yildizdas RD, et al. Neuroinfluenza: evaluation of seasonal influenza associated severe neurological complications in children (a multicenter study). Childs Nerv Syst 2018;34(2):335-47. google scholar
• 12. Unal S, Gökçe M, Aytaç-Elmas S, Karabulut E, Altan I, Ozkaya-Parlakay A, et al. Hematological consequences of pandemic influenza H1N1 infection: a single center experience. Turk J Pediatr 2010;52(6):570-5. google scholar
• 13. Cinemre H, Karacer C, Yücel M, Öğütlü A, Cinemre FB, Tamer A, et al. Viral etiology in adult influenza-like illness/acute respiratory infection and predictivity of C- reactive protein. J Infect Dev Ctries 2016;2;10(7):741-6. google scholar
• 14. Whitley RJ, Hayden FG, Reisinger KS, Young N, Dutkowski R, Ipe D, et al. Oral oseltamivir treatment of influenza in children. Pediatr Infect Dis J 2001;20(2):127-33. google scholar
• 15. Appiah GD, Chaves SS, Kirley PD, Miller L, Meek J, Anderson E, et al. Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010-2015. Clin Infect Dis 2017;1;64(3):364-7. google scholar