BibTex RIS Kaynak Göster

PFAPA Sendromunda Prokalsitonin Düzeyleri

Yıl 2017, Cilt: 17 Sayı: 3, 122 - 126, 01.07.2017
https://doi.org/10.5222/j.child.2017.122

Öz

Amaç: PFAPA sendromu tanısı konan çocuklarda febril atak sırasında prokalsitonin PCT düzeylerinin araştırılması. Gereç ve Yöntem: Çalışmaya 91 ateşli atak geçiren toplam 39 vaka ile bakteriyel septisemi tanısı konan 35 vaka kontrol grubu olarak alındı. Demografik, klinik ve laboratuvar bulguları kaydedildi. Her iki grupta hemogram, CRP ve PCT değerleri araştırıldı. Bulgular: Çalışma grubunda atak süresi ort 4,6 ±0,45 gün olup atak sıklıkları arasındaki süre ort 25,06±9,76 gün olarak saptandı. Çalışma grubunda ortalama lökosit, CRP and PCT değerleri sırasıyla 15,959±5,737/mm3, 76,88±47,63 mg/L ve 0,18±0,10 ng/mL bulundu. PFAPA sendromlu hastalarda boğaz kültürlerinde üreme saptanmadı. Kontrol grubundaki vakaların 20’si kız, 15’i erkekti. Ortalama lökosit sayısı 16,700±5,820/mm3 saptanırken, CRP değeri ise 34,64±18,61 mg/L, PCT düzeyi 2,12±1,95 ng/mL ölçüldü. Lökosit değerleri açısından iki grup arasında fark bulunamazken p>0,05 , PCT değerleri kontrol grubunda anlamlı düzeyde yüksekti p

Kaynakça

  • Marshall GS, edwards KM, butler J, Lawton Ar. Syndrome sof periodic fever, pharyngitis and aphtous stomatitis. J Pediatr 1987;110:43-6. https://doi.org/10.1016/S0022-3476(87)80285-8
  • Giannoussi e, Karatzanis aD, Bitsori m, helidonis eS. PFAPA syndrome in children evaluated for tonsil- lectomy. Arch Dis Child 2002;86:434-5. https://doi.org/10.1136/adc.86.6.434
  • Kraszewska-Głomba B, szymańska-toczek Z, Szenborn L. Procalcitonin and C-reactive protein- based decision tree model for distinguishing PFAPA flares from acute infections. Bosn J Basic Med Sci 2016;16:157-61. https://doi.org/10.17305/bjbms.2016.974
  • Kraszewska-Głomba B, matkowska-Kocjan a, Szenborn L. The pathogenesis of periodic fever, apht- hous stomatitis, pharyngitis, and cervical adenitis syn- drome: a review of current research. Mediators Inflamm 2015;2015:563876. https://doi.org/10.1155/2015/563876
  • Yamazaki t, hokibara s, shigemura t, et al. Markedly elevated CD64 expressions on neutrophils and monocytes are useful for diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome during flares. Clinical Rheumatology 2014;33:677-83. https://doi.org/10.1007/s10067-014-2542-1
  • Forsvoll J, Kristoffersen eK, oymar K. Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indi- cation of a persistent activation of the innate immune system. Pediatric Rheumatology Online Journal 2013;11:38. https://doi.org/10.1186/1546-0096-11-38
  • Prat c, domínguez J, rodrigo c, Gimenez M, Azuara M, Jimenez o, et al. Procalcitonin, C-reactive protein and leukocyte count in children with lower respiratory tract infection. Pediatr Infect Dis J 2003;22:963-8. https://doi.org/10.1097/01.inf.0000095197.72976.4f
  • Galetto-Lacour A, zamora SA, Gervaix A. Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center. Pediatrics 2003;112:1054-60. https://doi.org/10.1542/peds.112.5.1054
  • Padeh S, brezniak N, zemer d, Pras e, Livneh A, Langevitz P, et al. Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical charac- teristics and outcome. J Pediatr 1999;135:98-101. https://doi.org/10.1016/S0022-3476(99)70335-5
  • yoshihara T, ımamura T, yokoi K, et al. Potential use of procalcitonin oncentrations as a diagnostic marker of the PFAPA syndrome. Eur J Pediatr 2007; 166:621-2. https://doi.org/10.1007/s00431-006-0281-2
  • Yazgan h, Keles e, Yazgan Z, Gebesce a, demirdöven G. C-reactive protein and procalcitonin during febril attacks in PFAPA syndrome. Int J Pediatr Otorhinolaryngol 2012;76:1145-7. https://doi.org/10.1016/j.ijporl.2012.04.022
  • Feder hm, salazar JC. A clinical review of 105 patients with PFAPA (a periodic fever syndrome). Acta Paediatr 2010;99:178-84.
  • Padeh S. Periodic fever syndromes. Pediatr Clin North Am 2005;52:577-609. https://doi.org/10.1016/j.pcl.2005.01.005
  • thomas Kt, Feder hm Jr, Lawton ar, edwards KM. Periodic fever syndrome in children. J Pediatr 1999; 135:15-21. https://doi.org/10.1016/S0022-3476(99)70321-5
  • Tasher d, SteinM, dalal ı, Somekh e. Colchicine prophylaxis for frequent periodic fever, aphthous stom- atitis, pharyngitis and adenitis episodes. Acta Paediatr 2008;97:1090-2. https://doi.org/10.1111/j.1651-2227.2008.00837.x
  • Mahajan P, Grzybowski M, chen X, Kannikeswaran N, Stanley r, Singal b, et al. Procalcitonin as a marker of serious bacterial infections in febrile children younger than 3 years old. Acad Emerg Med 2014;21: 171-9. https://doi.org/10.1111/acem.12316
  • Padeh S, bezniak N, zemer d, Pras e, Livneh A, Langevitz P, et al. Periodic fever, aphthous stomatitis, pharyngitis and adenopathy syndrome : clinical charac- teristics and outcome. J Pediatr 1999;135:98-101. https://doi.org/10.1016/S0022-3476(99)70335-5
  • Vanoni F, theodoropoulou K, hofer m. PFAPA syn- drome: a review on treatment and outcome. Pediatr Rheumatol 2016;27(14):389.
  • Celiksoy mh, ogur G, Yaman e, abur U, Fazla s, Sancak r, yildiran A. Could familial Mediterranean fever gene mutations be related to PFAPA syndrome? Pediatr Allergy Immunol 2016;27:78-82. https://doi.org/10.1111/pai.12490
  • stojanov s, Lapidus s, Chitkara P, Feder h, salazar Jc, Fleisher TA, et al. Periodic fever, aphthous stoma- titis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade. Proc Natl Acad Sci U S A 2011;108:7148- 53. https://doi.org/10.1073/pnas.1103681108
  • Vigo G, zulian F. Periodic fevers with aphthous stomatitis, pharyngitis, and adenitis (PFAPA). Autoimmunity Reviews 2012;12:52-5. https://doi.org/10.1016/j.autrev.2012.07.021
  • Tasher d, SteinM, dalal ı, Somekh e. Colchicine prophylaxis for frequent periodic fever, aphthous stom- atitis, pharyngitis and adenitis episodes. Acta Paediatr 2008;97:1090-2. https://doi.org/10.1111/j.1651-2227.2008.00837.x
  • Lierl Mb. Efficacy of Montelukast for Treatment of Periodic Fever with Aphthous Stomatitis, Pharyngitis and Cervical Adenitis Syndrome (PFAPA). J Allergy Clin Immunol 2008 Abstract S228.
  • Pignataro L, Torretta S, Pietrogrande Mc, dellepiane rM, Pavesi P, bossi A, et al. Outcome of tonsillectomy in selected patients with PFAPA syn- drome. Arch Otolaryngol Head Neck Surg 2009; 135:548-53. https://doi.org/10.1001/archoto.2009.5
  • Garavello W, Pignataro L, Gaini L, Torretta S, Somigliana e, Gaini r. Tonsillectomy in children with periodic fever with aphthous stomatitis, pharyngi- tis, and adenitis syndrome. J Pediatr 2011;159:138- 42. https://doi.org/10.1016/j.jpeds.2010.12.014

Procalcitonin Levels in PFAPA Syndrome

Yıl 2017, Cilt: 17 Sayı: 3, 122 - 126, 01.07.2017
https://doi.org/10.5222/j.child.2017.122

Öz

Objective: To investigate procalcitonin PCT levels during febrile attacks in children diagnosed with the Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome PFAPA . Material and Method: A total of 39 cases with 91 febril episodes and 35 cases with bacterial septicemia were included in the study. Demographic, clinical, and laboratory data were collected. Hemogram, C-reactive values CRP and PCT values of all patients were measured. Results: In the study group with PFAPA, average duration of fever was 4.6±0.85 days, and the average time between attacks was 25.06±9.76 days. The mean white blood cell WBC , CRP and PCT values were found to be 15.959±5.737/mm3, 76.88±47.63 mg/L, and 0.18±0.10 ng/mL respectively. Throat cultures in the PFAPA group showed no growth. Twenty patients in the control group were female and 15 were male. The average WBC count was 16.700±5.820/mm3. The mean CRP and PCT values were measured as 34.64±18.2 mg/L and 2.12±1.95 ng/mL, respectively. While the mean WBC values did not significantly differ between the two groups p>0.05 , PCT levels were significantly higher in the controls compared to the PFAPA group p

Kaynakça

  • Marshall GS, edwards KM, butler J, Lawton Ar. Syndrome sof periodic fever, pharyngitis and aphtous stomatitis. J Pediatr 1987;110:43-6. https://doi.org/10.1016/S0022-3476(87)80285-8
  • Giannoussi e, Karatzanis aD, Bitsori m, helidonis eS. PFAPA syndrome in children evaluated for tonsil- lectomy. Arch Dis Child 2002;86:434-5. https://doi.org/10.1136/adc.86.6.434
  • Kraszewska-Głomba B, szymańska-toczek Z, Szenborn L. Procalcitonin and C-reactive protein- based decision tree model for distinguishing PFAPA flares from acute infections. Bosn J Basic Med Sci 2016;16:157-61. https://doi.org/10.17305/bjbms.2016.974
  • Kraszewska-Głomba B, matkowska-Kocjan a, Szenborn L. The pathogenesis of periodic fever, apht- hous stomatitis, pharyngitis, and cervical adenitis syn- drome: a review of current research. Mediators Inflamm 2015;2015:563876. https://doi.org/10.1155/2015/563876
  • Yamazaki t, hokibara s, shigemura t, et al. Markedly elevated CD64 expressions on neutrophils and monocytes are useful for diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome during flares. Clinical Rheumatology 2014;33:677-83. https://doi.org/10.1007/s10067-014-2542-1
  • Forsvoll J, Kristoffersen eK, oymar K. Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indi- cation of a persistent activation of the innate immune system. Pediatric Rheumatology Online Journal 2013;11:38. https://doi.org/10.1186/1546-0096-11-38
  • Prat c, domínguez J, rodrigo c, Gimenez M, Azuara M, Jimenez o, et al. Procalcitonin, C-reactive protein and leukocyte count in children with lower respiratory tract infection. Pediatr Infect Dis J 2003;22:963-8. https://doi.org/10.1097/01.inf.0000095197.72976.4f
  • Galetto-Lacour A, zamora SA, Gervaix A. Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center. Pediatrics 2003;112:1054-60. https://doi.org/10.1542/peds.112.5.1054
  • Padeh S, brezniak N, zemer d, Pras e, Livneh A, Langevitz P, et al. Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical charac- teristics and outcome. J Pediatr 1999;135:98-101. https://doi.org/10.1016/S0022-3476(99)70335-5
  • yoshihara T, ımamura T, yokoi K, et al. Potential use of procalcitonin oncentrations as a diagnostic marker of the PFAPA syndrome. Eur J Pediatr 2007; 166:621-2. https://doi.org/10.1007/s00431-006-0281-2
  • Yazgan h, Keles e, Yazgan Z, Gebesce a, demirdöven G. C-reactive protein and procalcitonin during febril attacks in PFAPA syndrome. Int J Pediatr Otorhinolaryngol 2012;76:1145-7. https://doi.org/10.1016/j.ijporl.2012.04.022
  • Feder hm, salazar JC. A clinical review of 105 patients with PFAPA (a periodic fever syndrome). Acta Paediatr 2010;99:178-84.
  • Padeh S. Periodic fever syndromes. Pediatr Clin North Am 2005;52:577-609. https://doi.org/10.1016/j.pcl.2005.01.005
  • thomas Kt, Feder hm Jr, Lawton ar, edwards KM. Periodic fever syndrome in children. J Pediatr 1999; 135:15-21. https://doi.org/10.1016/S0022-3476(99)70321-5
  • Tasher d, SteinM, dalal ı, Somekh e. Colchicine prophylaxis for frequent periodic fever, aphthous stom- atitis, pharyngitis and adenitis episodes. Acta Paediatr 2008;97:1090-2. https://doi.org/10.1111/j.1651-2227.2008.00837.x
  • Mahajan P, Grzybowski M, chen X, Kannikeswaran N, Stanley r, Singal b, et al. Procalcitonin as a marker of serious bacterial infections in febrile children younger than 3 years old. Acad Emerg Med 2014;21: 171-9. https://doi.org/10.1111/acem.12316
  • Padeh S, bezniak N, zemer d, Pras e, Livneh A, Langevitz P, et al. Periodic fever, aphthous stomatitis, pharyngitis and adenopathy syndrome : clinical charac- teristics and outcome. J Pediatr 1999;135:98-101. https://doi.org/10.1016/S0022-3476(99)70335-5
  • Vanoni F, theodoropoulou K, hofer m. PFAPA syn- drome: a review on treatment and outcome. Pediatr Rheumatol 2016;27(14):389.
  • Celiksoy mh, ogur G, Yaman e, abur U, Fazla s, Sancak r, yildiran A. Could familial Mediterranean fever gene mutations be related to PFAPA syndrome? Pediatr Allergy Immunol 2016;27:78-82. https://doi.org/10.1111/pai.12490
  • stojanov s, Lapidus s, Chitkara P, Feder h, salazar Jc, Fleisher TA, et al. Periodic fever, aphthous stoma- titis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade. Proc Natl Acad Sci U S A 2011;108:7148- 53. https://doi.org/10.1073/pnas.1103681108
  • Vigo G, zulian F. Periodic fevers with aphthous stomatitis, pharyngitis, and adenitis (PFAPA). Autoimmunity Reviews 2012;12:52-5. https://doi.org/10.1016/j.autrev.2012.07.021
  • Tasher d, SteinM, dalal ı, Somekh e. Colchicine prophylaxis for frequent periodic fever, aphthous stom- atitis, pharyngitis and adenitis episodes. Acta Paediatr 2008;97:1090-2. https://doi.org/10.1111/j.1651-2227.2008.00837.x
  • Lierl Mb. Efficacy of Montelukast for Treatment of Periodic Fever with Aphthous Stomatitis, Pharyngitis and Cervical Adenitis Syndrome (PFAPA). J Allergy Clin Immunol 2008 Abstract S228.
  • Pignataro L, Torretta S, Pietrogrande Mc, dellepiane rM, Pavesi P, bossi A, et al. Outcome of tonsillectomy in selected patients with PFAPA syn- drome. Arch Otolaryngol Head Neck Surg 2009; 135:548-53. https://doi.org/10.1001/archoto.2009.5
  • Garavello W, Pignataro L, Gaini L, Torretta S, Somigliana e, Gaini r. Tonsillectomy in children with periodic fever with aphthous stomatitis, pharyngi- tis, and adenitis syndrome. J Pediatr 2011;159:138- 42. https://doi.org/10.1016/j.jpeds.2010.12.014
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makaleleri
Yazarlar

Nalan Karabayır Bu kişi benim

Serdar Al

Tijen Alkan Bozkaya Bu kişi benim

Ali Demirhan Bu kişi benim

Meliha Aksoy Okan Bu kişi benim

Yayımlanma Tarihi 1 Temmuz 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 17 Sayı: 3

Kaynak Göster

APA Karabayır, N., Al, S., Alkan Bozkaya, T., Demirhan, A., vd. (2017). Procalcitonin Levels in PFAPA Syndrome. Çocuk Dergisi, 17(3), 122-126. https://doi.org/10.5222/j.child.2017.122
AMA Karabayır N, Al S, Alkan Bozkaya T, Demirhan A, Aksoy Okan M. Procalcitonin Levels in PFAPA Syndrome. Çocuk Dergisi. Temmuz 2017;17(3):122-126. doi:10.5222/j.child.2017.122
Chicago Karabayır, Nalan, Serdar Al, Tijen Alkan Bozkaya, Ali Demirhan, ve Meliha Aksoy Okan. “Procalcitonin Levels in PFAPA Syndrome”. Çocuk Dergisi 17, sy. 3 (Temmuz 2017): 122-26. https://doi.org/10.5222/j.child.2017.122.
EndNote Karabayır N, Al S, Alkan Bozkaya T, Demirhan A, Aksoy Okan M (01 Temmuz 2017) Procalcitonin Levels in PFAPA Syndrome. Çocuk Dergisi 17 3 122–126.
IEEE N. Karabayır, S. Al, T. Alkan Bozkaya, A. Demirhan, ve M. Aksoy Okan, “Procalcitonin Levels in PFAPA Syndrome”, Çocuk Dergisi, c. 17, sy. 3, ss. 122–126, 2017, doi: 10.5222/j.child.2017.122.
ISNAD Karabayır, Nalan vd. “Procalcitonin Levels in PFAPA Syndrome”. Çocuk Dergisi 17/3 (Temmuz 2017), 122-126. https://doi.org/10.5222/j.child.2017.122.
JAMA Karabayır N, Al S, Alkan Bozkaya T, Demirhan A, Aksoy Okan M. Procalcitonin Levels in PFAPA Syndrome. Çocuk Dergisi. 2017;17:122–126.
MLA Karabayır, Nalan vd. “Procalcitonin Levels in PFAPA Syndrome”. Çocuk Dergisi, c. 17, sy. 3, 2017, ss. 122-6, doi:10.5222/j.child.2017.122.
Vancouver Karabayır N, Al S, Alkan Bozkaya T, Demirhan A, Aksoy Okan M. Procalcitonin Levels in PFAPA Syndrome. Çocuk Dergisi. 2017;17(3):122-6.