Çocukluk Çağının Sentrotemporal Dikenli Selim Epilepsisinde Tedavi Yaklaşımı ve Prognoz

Yıl 2016, Cilt: 16 Sayı: 1, 11 - 15, 01.02.2016

Gonca Bektaş Edibe Pembegül Yıldız Mine Çalışkan

https://doi.org/10.5222/j.child.2016.011

Öz

Çocukluk çağının sentrotemporal dikenli selim epilepsisi rolandik epilepsi , çocukluk çağında en sık görülen fokal epilepsi sendromudur. Bu hastalığın selim bir seyri olduğu kabul edilmesine karşın konuşma, davranış anormallikleri- ne ve kognitif bozulmaya yol açabileceği bildirilmiştir. Nöbet sıklığından bağımsız olarak, interiktal rolandik epi- leptiform deşarjların nörofizyolojik fonksiyonlar açısından potansiyel bir risk faktörü olduğu öne sürülmektedir. Rolandik epilepsinin tipik klinik seyri ile bu hastalar üze- rinde yapılan nörofizyolojik çalışmalar irdelenmiştir

Anahtar Kelimeler

Rolandik epilepsi, antiepileptik ilaçlar, çocukluk çağı epilepsisi

Therapeutic Management and Prognosis in Benign Epilepsy with Centrotemporal Spikes in Childhood

Öz

Benign epilepsy with centrotemporal spikes rolandic epi- lepsy is the most common childhood focal epilepsy syn- drome. Although rolandic epilepsy is characterized by a benign clinical course, deterioration of language, behaviour, and cognitive functions have been also reported. Interictal rolandic epileptiform discharges are suggested to be a potential risk factor for neurophysiological impairment regardless of frequency of seizures. Typical clinical course of rolandic epilepsy and neurophysiological studies performed on patients with rolandic epilepsy were evaluated

Anahtar Kelimeler

Rolandic epilepsy, antiepileptic drugs, childhood benign epilepsy

Kaynakça

• Engel J Jr, Pedley Ta, Fejerman n. Benign child- hood epilepsy with centrotemporal spikes. In: Engel J Jr, Pedley TA, editors. Philadelphia: Lippincott Williams & Wilkins: A Wolters Kluwer Business; 2008. p. 2369-77.
• Panayiotopoulos CP, Michael M, Sanders S, Valeta T, koutroumanidis M. Benign childhood focal epilep- sies: assessment of established and newly recognized syndromes. Brain 2008;131:2264-86. https://doi.org/10.1093/brain/awn162
• larson k, Eeg-Olofsson O. A population based study of epilepsy in children from a Swedish county. Eur J Paediatr Neurol 2006;10:107-13. https://doi.org/10.1016/j.ejpn.2006.02.005
• Parmeggiani l, Seri S, Bonanni P, Guerrini R. Electrophysiological characterization of spontaneous and carbamazepine-induced epileptic negative myoclo- nus in benign childhood epilepsy with centro-temporal spikes. Clin Neurophysiol 2004;115:50-8. https://doi.org/10.1016/S1388-2457(03)00327-4
• Panayiotopoulos CP. Benign childhood partial epilep- sies: benign childhood seizure susceptibility syn- dromes. J Neurol Neurosurg Psychiatr 1993;56:2-5. https://doi.org/10.1136/jnnp.56.1.2
• Bali B, kull ll, Strug lJ, Clarke T, Murphy Pl, akman Cı, et al. Autosomal dominant inheritance of centrotemporal sharp waves in rolandic epilepsy fami- lies. Epilepsia 2007;48:2266-72. https://doi.org/10.1111/j.1528-1167.2007.01221.x
• neubauer Ba, Fiedler B, Himmelein B, kampfer F, lassker U, Schwabe G, et al. Centrotemporal spikes in families with rolandic epilepsy: linkage to chromo- some 15q14. Neurology 1998;51:1608-12. https://doi.org/10.1212/WNL.51.6.1608
• Panayiotopoulos CP. Benign childhood partial sei- zures and related epileptic syndromes. London: John Libbey & Company Ltd; 1999.
• Okubo Y, Matsuura M, asai T, asai k, kato M, kojima T, et al. Epileptiform EEG discharges in healthy children: prevalence, emotional and behavioral correlates, and genetic influences. Epilepsia 1994;35:832-41. https://doi.org/10.1111/j.1528-1157.1994.tb02520.x
• Verrotti a, Matricardi S, Di Giacomo Dl, Rapino D, Chiarelli F, Coppola G. Neuropsychological impairment in children with Rolandic epilepsy and in their siblings. Epilepsy Behav 2013;28:108-12. https://doi.org/10.1016/j.yebeh.2013.04.005
• Tan HJ, Singh J, Gupta R, de Goede C. Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes. Cochrane Database Syst Rev 2014; CD006779. https://doi.org/10.1002/14651858.cd006779.pub2
• Wheless JW, Clarke DF, arzimanoglou a, Carpenter D. Treatment of pediatric epilepsy: European expert opinion. Epileptic Disord 2007;9:353-412.
• Ben zeev B, Watemberg n, lerman P, Barash ı, Brand n, lerman-Sagie T. Sulthiame in childhood epilepsy. Pediatr Int 2004;46:521-4. https://doi.org/10.1111/j.1442-200x.2004.01954.x
• kikumoto k, Yoshinaga H, Oka M, ıto M, Endoh F, akiyama T, et al. EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syn- drome. Epileptic Disord 2006;8:53-6.
• Xiao F, an D, lei D, li l, Chen S, Wu X, et al. Real- time effects of centrotemporal spikes on cognition in rolandic epilepsy: An EEG-fMRI study. Neurology 2016;86:544-51. https://doi.org/10.1212/WNL.0000000000002358
• aicardi J. Atypical semiology of rolandic epilepsy in some related syndromes. Epileptic Disord 2000;2 Suppl 1: S5-9.